Dietary Folate, Methionine, Riboflavin, and Vitamin B-6 and Risk of Sporadic Colorectal Cancer

Vogel, Stefan de; Dindore, Vasundhara; Engeland, Manon van; Goldbohm, R. Alexandra; Brandt, Piet A. van den; Weijenberg, Matty P.

doi:10.3945/jn.108.091157

Cited by 86 publications

(98 citation statements)

References 44 publications

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“…Because folic acid plays an important role in DNA methylation and cellular homeostasis, folate deficiency might impair these processes and cause chromosomal breaks, as well as deleterious changes in gene expression. All of these factors might induce genomic instability and aberrant DNA methylation, which contribute to carcinogenesis (22,26,27). Data from our clinical trial clearly support a chemopreventive role for folic acid in primary prevention of CRA, especially in patients older than 50 years.…”

Section: Discussionmentioning

confidence: 57%

Folic Acid Prevents the Initial Occurrence of Sporadic Colorectal Adenoma in Chinese Older than 50 Years of Age: A Randomized Clinical Trial

Gao

Chen

et al. 2013

Cancer Prevention Research

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Colorectal adenoma (CRA) is the precursor lesion of colorectal cancer (CRC). Several agents have been shown to be effective in the chemoprevention of CRA recurrence, but there has been little research on its primary prevention. Participants older than 50 years with no adenomas were recruited for our study and randomized to receive either 1 mg/day folic acid supplement or treatment without folic acid. After 3 years of follow-up, plasma folate and colonoscopy were evaluated. Seven hundred ninety-one participants (91.98%) completed the study. CRA occurred in 64 (14.88%) participants in the folic acid group and 132 (30.70%) in the control group [unadjusted risk ratio (RR), 0.49; 95% confidence interval (CI), 0.37-0.63; P < 0.01]; left-sided adenoma (unadjusted RR, 0.54; 95% CI, 0.38-0.76; P ¼ 0.001) and advanced CRA (unadjusted RR, 0.36; 95% CI, 0.16-0.81; P ¼ 0.01) were most common. There was no significance difference in the occurrence of three or more adenomas (unadjusted RR, 0.70; 95% CI, 0.36-1.77; P ¼ 0.38) or right-sided adenoma (unadjusted RR, 0.55; 95% CI, 0.30-1.00; P ¼ 0.07) between the two groups. Participants with low plasma folate may have a high risk of CRA. In conclusion, primary prevention with 1 mg/day folic acid supplementation could reduce the incidence of CRA, especially left-sided and advanced disease in those with no previous adenomas. People with differing baseline plasma folate levels should be given individualized treatment. Those with low plasma folate should be encouraged to take adequate supplements; plasma folate should be elevated to an effective therapeutic level, which may reduce the incidence of CRA. Cancer Prev Res; 6(7); 744-52. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 57%

Folic Acid Prevents the Initial Occurrence of Sporadic Colorectal Adenoma in Chinese Older than 50 Years of Age: A Randomized Clinical Trial

Gao

Chen

et al. 2013

Cancer Prevention Research

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“…Cho and colleagues (3) previously reported a positive association of choline intake and an inverse association of betaine intake with distal colorectal adenoma risk among women, whereas no associations were observed with colorectal cancer among men (4). Methionine intake was not associated with colorectal cancer risk in several studies (5)(6)(7)(8)(9)(10)(11)(12)(13). However, the associations of plasma concentrations of methionine, choline, and betaine with risk of colorectal adenomas or carcinomas have not been studied so far.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers Related to One-Carbon Metabolism as Potential Risk Factors for Distal Colorectal Adenomas

Vogel

Schneede

Ueland

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Efficient one-carbon metabolism, which requires adequate supply of methyl group donors and B-vitamins, may protect against colorectal carcinogenesis. However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome.Methods: This study comprised 10,601 individuals, 50 to 64 years of age, participating in the Norwegian Colorectal Cancer Prevention (NORCCAP) screening study. Using logistic regression analyses, we crosssectionally investigated associations between distal colorectal adenoma occurrence-potential precursor lesions of colorectal carcinomas-and plasma concentrations of methyl group donors and B-vitamins, and polymorphisms of genes related to one-carbon metabolism.Results: Screening revealed 1,809 subjects (17.1%) with at least one adenoma. The occurrence of high-risk adenomas (observed in 421 subjects) was inversely associated with plasma concentrations of methionine (highest versus lowest quartile: odds ratio (

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“…Briefly, we reviewed 9 articles of vitamin B2 intake and risk of colorectal cancer (La Vecchia et al, 1997;Jedrychowski et al, 2001;Shin et al, 2006;de Vogel et al, 2008;E Ma et al, 2009;Shrubsole et al, 2009;van Lee et al, 2011;Bassett et al, 2013;Zschabitz et al, 2013), published from 1997 to 2013. But we found the article has been published by Shin in 2006 and the article has been published by Shrubsole in 2009 are using the same cohort: The Shanghai Women's Health Study (SWHS).…”

Section: Literature Searchmentioning

confidence: 99%

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Liu¹,

Yu²,

Zhu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (3), 909-913 IntroductionIn 2013, colorectal cancer was newly diagnosed in 73,680 males in the United States; 26,300 died of the disease. It was newly diagnosed in 69,140 females and 24,530 died (Siegel et al., 2013). Indeed, colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, with more than 1.2 million new cases and 608,700 deaths estimated to have occurred in 2008 (Center et al., 2009.Vitamin B2 (chemical formula: C17H20N4O6) also known as riboflavin . In fact, the flavin in riboflavin comes from flavus, the Latin word for yellow. (yellow enzymes play a role of hydrogen in the biological oxidation reduction). Vitamin B2 is one of many nutrients required to recycle glutathione, which is one of the most important antioxidants in the human body. (From a chemical standpoint, what B2 does is facilitate the conversion of oxidized glutathione into reduced glutathione.) (Yasuda and Hiraoka, 1999).Riboflavin is unique among the water-soluble vitamins in that milk and dairy products make the greatest contribution to its intake in Western diets. Meat and fish are also good sources of riboflavin, and certain fruit and vegetables, especially dark-green vegetables, contain reasonably high concentrations (Powers, 2003). Vitamin B2 has limited storage , So it need a food supplement Conclusions: This is the first meta-analysis to study links between vitamin B2 and colorectal cancer. We found vitamin B2 intake was inversely associated with risk of colorectal cancer. However, further research and large sample studies need to be conducted to better validate the result.

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Dietary Folate, Methionine, Riboflavin, and Vitamin B-6 and Risk of Sporadic Colorectal Cancer

Cited by 86 publications

References 44 publications

Folic Acid Prevents the Initial Occurrence of Sporadic Colorectal Adenoma in Chinese Older than 50 Years of Age: A Randomized Clinical Trial

Folic Acid Prevents the Initial Occurrence of Sporadic Colorectal Adenoma in Chinese Older than 50 Years of Age: A Randomized Clinical Trial

Biomarkers Related to One-Carbon Metabolism as Potential Risk Factors for Distal Colorectal Adenomas

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

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