Dietary Fructooligosaccharides Induce Immunoregulation of Intestinal IgA Secretion by Murine Peyer's Patch Cells

Hosono, Akira; Ozawa, Akane; Kato, Ryuichi; Ohnishi, Y; Nakanishi, Yusuke; Kimura, Teiji; Nakamura, Ryo

doi:10.1271/bbb.67.758

Cited by 197 publications

(180 citation statements)

References 36 publications

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“…The present study showed that maternal supplementation with 1-kestose significantly increased the amount of total IgA in the intestinal tracts of lactating mice (Table 3), supporting previous reports [12][13][14] that dietary FOS or 1-kestose intensifies IgA production in the digestive tract. The authors had also previously confirmed that dietary FOS promotes IgA + B cell class switching in the Peyer's patches of the small intestine, 13) 16) Considering that the fecal Bacteroides count was higher in the 1-kestose-supplemented group than the control group, in the present study (Table 2), the increase in IgA levels in the intestinal mucosa might be caused by an increased number of IgA-producing plasma cells in the digestive tract.…”

Section: Discussionsupporting

confidence: 92%

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1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Jinno

Nakamura

Nagata

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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To examine the effect of dietary supplementation with 1-kestose on the IgA levels in milk, BALB/c mice were fed diets with or without 5% 1-kestose during pregnancy and lactation. The total and specific IgA levels in the milk were measured at 7 and 14 days after delivery. A two-way ANOVA with repeated measures resulted in a significant effect of 1-kestose-supplementation on total IgA concentrations (p < 0.05) and the level of anti-Bacteroides IgA (p < 0.05). A significant positive correlation was found between the mean count of Bacteroides spp. in maternal feces and the total IgA concentration in maternal milk (r = 0.55, p < 0.05), suggesting a potential link between the gut and mammary gland immune system. In conclusion, this study demonstrated the effects of dietary prebiotics on milk IgA production.

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Section: Discussionsupporting

confidence: 92%

“…11) Several studies have shown that supplementation with 1-kestose or FOS leads to increased production of IgA in the digestive tract of rodents. [12][13][14][15] In animals, intestinal microbiota can affect intestinal IgA levels. Previous reports have shown the existence of a relationship between the cecal lactobacilli count and intestinal IgA levels in rats.…”

mentioning

confidence: 99%

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Jinno

Nakamura

Nagata

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…Field et al, 1999;Schley and Field, 2002;Hosono et al, 2003). In this study, leukocyte counts in peripheral blood were decreased in lactulosetreated calves and monocyte numbers were decreased in both treatment groups.…”

Section: Discussionsupporting

confidence: 47%

“…The ileum wall is interstratified with Peyer's patches, parts of the gut-associated lymphoid tissue. Cells from these patches have been shown to release anti-inflammatory cytokines such as IL10 after stimulation with probiotics, prebiotics or fermentation products thereof (Sä emann et al, 2000;Hosono et al, 2003;Roller et al, 2004). Therefore, it seems probable that fermentation products deriving from inulin degradation or secretory molecules from bacteria stimulated by inulin feeding are causative agents in this increase of IL10 expression.…”

Section: Discussionmentioning

confidence: 99%

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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Prebiotics are suggested as an alternative to antibiotics in animal rearing. Fermentable substances such as inulin or lactulose have been proposed to stimulate the immune system and health by modulation of the intestinal flora and its fermentation products. In this study, effects of inulin and lactulose on the intestinal health and hematology of calves have been investigated. Both prebiotics significantly decreased thrombocyte counts in peripheral blood. Only inulin was able to increase hemoglobin concentration and hematocrit. Total leukocyte count was decreased by lactulose while both prebiotics tended to lower monocyte proportions. mRNA expression of inflammation-related markers in the intestine was also affected by both prebiotics hinting at a decreased inflammatory status. This may be due to a possible decrease in intestinal pathogen load that remains to be verified. Only mRNA amounts of interleukin 8 were increased by lactulose in mesenteric lymph nodes. In the ileum, expression of a proliferation marker was increased by inulin while an apoptosis-related gene was increased by both prebiotics. The results of this study show a clear effect of prebiotics on certain parameters associated with animal health and performance that remain to be studied in detail in future investigations.

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“…Neither was lymphocyte proliferation altered in the spleen of rats supplemented with OF-enriched IN (49) nor splenocyte proliferation in mice vaccinated against Salmonella typhimurium and supplemented with OF in combination with IN with shorter-chain FOS removed (47) . Thus, lymphocyte proliferation in the spleen appears not to be susceptible to modification by b2-1 fructans.As in the GALT, T cell cytokine production may be altered with b2-1 fructan supplementation: IFN-g production from spleen CD4 þ T cells was increased in mice supplemented with FOS, although IL-5 and IL-6 production were decreased (51) , and IL-12 and IFN-g production from splenocytes was increased upon supplementation with a combination of OF and IN with shorter-chain FOS removed in mice, although TNF-a production was not altered (47) . There was no effect of OFenriched IN supplementation in rats upon IL-10 production by splenocytes (57) , or upon cytokine production in the spleen (49) .…”

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confidence: 99%

Prebiotics, immune function, infection and inflammation: a review of the evidence

2008

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b2-1 Fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, b2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas. Twenty-one studies in laboratory animals suggest that some aspects of innate and adaptive immunity of the gut and the systemic immune systems are modified by b2-1 fructans. In man, two studies in children and nine studies in adults indicate that the adaptive immune system may be modified by b2-1 fructans. Thirteen studies in animal models of intestinal infections conclude a beneficial effect of b2-1 fructans. Ten trials involving infants and children have mostly reported benefits on infectious outcomes; in fifteen adult trials, little effect was generally seen, although in specific situations, certain b2-1 fructans may be beneficial. Ten studies in animal models show benefit of b2-1 fructans with regard to intestinal inflammation. Human studies report some benefits regarding inflammatory bowel disease (four positive studies) and atopic dermatitis (one positive study), but findings in irritable bowel syndrome are inconsistent. Therefore, overall the results indicate that b2-1 fructans are able to modulate some aspects of immune function, to improve the host's ability to respond successfully to certain intestinal infections, and to modify some inflammatory conditions. b2-1 Fructans: Inulin: Oligofructose: Fructo-oligosaccharides: Cytokines Prebiotics have been defined as 'non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth, and/or activity, of one or a limited number of beneficial bacteria in the colon and thus improve host health' (1) . Research on the potential health benefits of prebiotics has occurred over the last 15 years or so, with a recent interest in the effects on the immune system, the host's ability to fight infection, and inflammatory processes and conditions. These effects have been reviewed several times (2 -7) but to our knowledge there are no reviews that bring together all of the available studies in all of the these areas. Thus, the aim of the present article is to describe the structure and dietary sources of prebiotics, and to summarise and evaluate studies investigating the influence of prebiotics on immunity, host defence, and inflammatory processes and conditions.Structure of prebiotics b2-1 Fructans, which include inulin (IN) and fructo-oligosaccharides (FOS), fulfil the criteria for prebiotics (8) . Other carbohydrates including galacto-oligosaccharides (GOS), gluco-oligosaccharides, isomalto-oligosaccharides, lactulose, mannanoligosaccharides (MOS), nigero-oli...

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Dietary Fructooligosaccharides Induce Immunoregulation of Intestinal IgA Secretion by Murine Peyer's Patch Cells

Cited by 197 publications

References 36 publications

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Prebiotics, immune function, infection and inflammation: a review of the evidence

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