Dietary genistein supplementation improves intestinal mucosal barrier function in Escherichia coli O78-challenged broilers

Zhang, Ming; Kou, Jiao; Wu, Yujun; Wang, Mengmeng; Zhou, Xiumin; Yang, Ying; Wu, Zhenlong

doi:10.1016/j.jnutbio.2019.108267

Cited by 24 publications

(17 citation statements)

References 35 publications

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“…For example, temperature, humidity, ventilation and fecal treatment are closely related to the occurrence of colibacillosis. In addition, proper feed additive prevention is also an indispensable measure to prevent the occurrence of Escherichia coli disease ( 5 , 21 ). Previous study showed that dietary addition of Lactobacillus plantarum could improve the intestinal health and reduce the mortality of chickens suffering from Escherichia coli challenge ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…Avian pathogenic Escherichia coli (APEC) O78 has been associated with colibacillosis in chickens, which is one of the most common diseases of chicken farms (5). Sub-therapeutic antibiotics used as feed additives were effective against APEC infection.…”

Section: Introductionmentioning

confidence: 99%

“…Sub-therapeutic antibiotics used as feed additives were effective against APEC infection. However, due to pronounced increase in the emergence of multiple resistance of Escherichia coli infection, it is necessary to develop safe alternative to reduce Escherichia coli-infection (5). Heat stress is one of the most challenging environmental conditions for the poultry industry and has negative effects on health and productivity of chickens (6).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Probiotic Properties of Lactobacillus salivarius Isolated From Chickens as Feed Additives

et al. 2020

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The continued use of sub-therapeutic antibiotics as feed additives in the poultry industry improved health and growth performance. However, the resulting antibiotic resistance increasingly becomes a major threat to public health. Probiotics are promising alternatives for the antibiotics used in poultry industry. The aim of this study was to evaluate the probiotic properties of Lactobacillus salivarius as feed additive in chickens. White leghorn chickens were randomly assigned to experimental groups. Effects of Lactobacillus salivarius supplementation on growth performance, resistance to Escherichia coli O78 challenge and heat-stress, and immune response after vaccinated with attenuated infectious bursal disease virus (IBDV) vaccine were determined. The results showed that Lactobacillus salivarius supplementation improved growth performance, such as weight and longer shank length, increased relative weights of the immune organs and decreased concentrations of odor-causing compounds. In addition, Lactobacillus salivarius supplementation alleviated organ injury caused by Escherichia coli O78 challenge and heat stress. Furthermore, Lactobacillus salivarius results in enhanced immune response after IBDV vaccine immunization, enhanced specific antibody and IFN-γ production, and lymphocyte proliferation. Our results revealed a tremendous potential of Lactobacillus salivarius as antibiotics' substitute in poultry production.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Probiotic Properties of Lactobacillus salivarius Isolated From Chickens as Feed Additives

et al. 2020

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“…Genistein, one of the major flavonoids in soy, is a potent inhibitor of protein kinases, and experimental models have demonstrated its ability to reduce acetaldehyde-induced TJ damage [ 230 , 231 , 232 ]. It was able to prevent TJ damage induced by E. coli in an experiment on broilers [ 233 ].…”

Section: Therapeutic Interventions To Restore Intestinal Barrier Integritymentioning

confidence: 99%

Intestinal Barrier in Human Health and Disease

Tommaso

Gasbarrini

Ponziani

2021

IJERPH

247

110

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The intestinal mucosa provides a selective permeable barrier for nutrient absorption and protection from external factors. It consists of epithelial cells, immune cells and their secretions. The gut microbiota participates in regulating the integrity and function of the intestinal barrier in a homeostatic balance. Pathogens, xenobiotics and food can disrupt the intestinal barrier, promoting systemic inflammation and tissue damage. Genetic and immune factors predispose individuals to gut barrier dysfunction, and changes in the composition and function of the gut microbiota are central to this process. The progressive identification of these changes has led to the development of the concept of ‘leaky gut syndrome’ and ‘gut dysbiosis’, which underlie the relationship between intestinal barrier impairment, metabolic diseases and autoimmunity. Understanding the mechanisms underlying this process is an intriguing subject of research for the diagnosis and treatment of various intestinal and extraintestinal diseases.

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“…E. coli infection in birds leads to severe diarrhea, decreased feed intake, and reduced growth performance, therefore causing serious economic losses in poultry industries ( Mellata, 2013 ). Several nutritional interventions have been attempted to ameliorate E. coli -induced intestinal barrier dysfunctions ( Wang et al, 2016 ; Zhang et al, 2020 ), eventually improving the intestinal development and health outcomes of broilers.…”

Section: Introductionmentioning

confidence: 99%

Dietary hydrolyzed wheat gluten supplementation ameliorated intestinal barrier dysfunctions of broilers challenged with Escherichia coli O78

Wen-yu²,

Kim

et al. 2022

Poultry Science

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This study aimed to investigate a protective effect of hydrolyzed wheat gluten ( HWG ) on Escherichia coli ( E. coli )-induced intestinal barrier dysfunctions in broilers. Broilers fed a basal diet unsupplemented or supplemented with HWG (0.5% or 1%) were intraperitoneally injected with either E. coli O78 suspension (10 8 CFU/mL) or equal volume of vehicle on d 18 of age. Blood and tissue samples were collected 3rd d post infection. The results showed that E. coli -infection increased immune-organ indexes of spleen and thymus, enhanced serum diamine oxidase ( DAO ) level, impaired ileal villus structure and reduced tight junction mRNA levels ( Occludin, Claudin-1, ZO-1, P < 0.05), while increased mRNA levels of inflammatory cytokines ( TNF-α, IFN-γ, IL-1β, IL-6, IL-8 ) and TLR4 in the ileum of broilers ( P < 0.05). The effects of E. coli O78 challenge on organ indexes of spleen and thymus, serum DAO level, mRNA levels of tight junctions were alleviated by 1% HWG supplementation, the upregulations of IL-1β and TLR4 were prevented by 0.5% HWG supplementation ( P < 0.05). In addition, increased IFN-γ of E. coli -infected broilers was abrogated by 0.5% or 1% HWG supplementation ( P < 0.05). In summary, dietary HWG supplementation ameliorated intestinal barrier dysfunctions triggered by E. coli -infection in the ileum of broilers. HWG supplementation might be a nutritional strategy to improve the intestinal mucosal barrier function of broilers.

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Dietary genistein supplementation improves intestinal mucosal barrier function in Escherichia coli O78-challenged broilers

Cited by 24 publications

References 35 publications

Assessment of Probiotic Properties of Lactobacillus salivarius Isolated From Chickens as Feed Additives

Assessment of Probiotic Properties of Lactobacillus salivarius Isolated From Chickens as Feed Additives

Intestinal Barrier in Human Health and Disease

Dietary hydrolyzed wheat gluten supplementation ameliorated intestinal barrier dysfunctions of broilers challenged with Escherichia coli O78

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