Dietary Guar Gum Reduces Lymph Flow and Diminishes Lipid Transport in Thoracic Duct‐Cannulated Rats

Shirouchi, Bungo; Kawamura, Sayaka; Matsuoka, Ryosuke; Baba, S.; Nagata, Kazuko; Shiratake, Sawako; Tomoyori, Hiroko; Imaizumi, Kazunori; Sato, Masao

doi:10.1007/s11745-011-3570-0

Cited by 13 publications

(12 citation statements)

References 19 publications

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“…The lower viscosity of the EW or EWH can indicate a higher dispersive activity in the digestive tract, which can be similarly observed in the case of a lipase inhibitor (e.g. water-soluble fiber) (21). It is possible that lower viscosity in the digestive tract leads to higher inhibition of lipid digestion and absorption because EW and EWH can have a higher dispersive activity in vivo.…”

Section: Resultsmentioning

confidence: 86%

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Ochiai

Misaki

Takeuchi

et al. 2017

J Nutr Sci Vitaminol

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Summary Egg white (EW) is known as a nutritional protein but can induce allergic reactions in humans. We investigated the dietary effects of EW and its hydrolysate (EWH), which contains less allergen, on body fat accumulation in Wistar rats fed an equicaloric high-fat and high-sucrose diet for 8 wk (Exp A). The pair-feeding of EW and equicaloric-feeding of EWH increased fecal fat excretion and suppressed lipid accumulation in the liver and muscles but not in the abdominal adipose tissues, carcass, or total body. Dietary EWH also suppressed the serum glucose level and alkaline phosphatase activity. Further, we showed a higher dispersibility of EW and EWH in physicochemical assay (Exp B). Next, we investigated the suppressive effects of a single administration of EW and EWH on lipid-induced hypertriglyceridemia and small intestinal meal transit in ddY mice (Exp C). However, a single administration of EW or EWH did not suppress the lipid-induced hypertriglyceridemia nor did it delay the rate of small intestinal transit. These findings indicated that dietary EW and EWH reduce hepatic and muscular (ectopic) fat accumulation mainly by suppressing fat absorption and supplying fat to the liver and muscles. Therefore, the low-allergenic EWH can be effective for the prevention of high-fat-diet-induced obesity.

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Section: Resultsmentioning

confidence: 86%

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Ochiai

Misaki

Takeuchi

et al. 2017

J Nutr Sci Vitaminol

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“…However, it has also been reported that water-soluble dietary fiber does not involve SCFAs and suppresses fatty acid accumulation itself. For example, water-soluble dietary fiber may form a highly viscous matrix in the small intestine, increase the viscosity of the small intestine, and then physically suppress fat absorption [65,66]. These reports should be considered when investigating the association between gut microbiota and lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule

et al. 2019

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Water-soluble dietary fiber is known to modulate fecal microbiota. Although there are a few reports investigating the effects of fiber intake timing on metabolism, there are none on the effect of intake timing on microbiota. Therefore, in this study, we examined the timing effects of inulin-containing food on fecal microbiota. Mice were housed under conditions with a two-meals-per-day schedule, with a long fasting period in the morning and a short fasting period in the evening. Then, 10–14 days after inulin intake, cecal content and feces were collected, and cecal pH and short-chain fatty acids (SCFAs) were measured. The microbiome was determined using 16S rDNA sequencing. Inulin feeding in the morning rather than the evening decreased the cecal pH, increased SCFAs, and changed the microbiome composition. These data suggest that inulin is more easily digested by fecal microbiota during the active period than the inactive period. Furthermore, to confirm the effect of fasting length, mice were housed under a one-meal-per-day schedule. When the duration of fasting was equal, the difference between morning and evening nearly disappeared. Thus, our study demonstrates that consuming inulin at breakfast, which is generally after a longer fasting period, has a greater effect on the microbiota.

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“…The WHCs of casein, EWP, C-ph, and EWPph were measured as described previously. 24 Samples (0.1 g) were placed on two filter papers fitted in a stainless steel container (hole diameter, 2.5 cm; diameter, 5 cm; height, 1.5 cm) with a polypropylene net. This weight was measured as dry weight.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Dietary Egg White Protein Inhibits Lymphatic Lipid Transport in Thoracic Lymph Duct-Cannulated Rats

Matsuoka

Shirouchi

Kawamura

et al. 2014

J. Agric. Food Chem.

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Dietary egg white protein (EWP) decreases serum cholesterol levels. We previously showed that EWP decreased cholesterol absorption in the intestine. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of dietary EWP on lipid transport. They were fed diets with 20% EWP and casein, and their lymph was collected to quantify lymphatic lipid levels. Dietary EWP decreased lymphatic cholesterol transport compared with casein. It was previously shown that EWP excluded cholesterol from bile acid micelles. Therefore, pepsin-hydrolyzed EWP and casein were prepared. EWP was not completely digested. Ovalbumin, which is the most abundant protein in EWP, showed resistance to digestion by pepsin. This study investigated the effects of EWP pepsin hydrolysate (EWP-ph) on cholesterol micellar solubility, cholesterol transfer from the micellar to the oil phase, water-holding capacity (WHC), settling volume in water (SV), and relative viscosity and compared them with the effects of casein pepsin hydrolysate (C-ph). EWP-ph significantly decreased the micellar solubility and transfer rate and increased the WHC, SV, and relative viscosity compared with C-ph. Moreover, the pepsin hydrolysate of ovalbumin, a major protein in EWP, played a role in decreasing cholesterol micellar solubility, leading to the inhibition of cholesterol absorption. In conclusion, dietary EWP decreased cholesterol intestinal absorption by exerting combined effects of these physicochemical properties in the gut.

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Dietary Guar Gum Reduces Lymph Flow and Diminishes Lipid Transport in Thoracic Duct‐Cannulated Rats

Cited by 13 publications

References 19 publications

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule

Dietary Egg White Protein Inhibits Lymphatic Lipid Transport in Thoracic Lymph Duct-Cannulated Rats

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