Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

Almeida-de-Souza, Juliana; Santos, Rute; Barros, Renata; Abreu, Sandra; Moreira, Carla; Lopes, Luís; Mota, Jorge; Moreira, Pedro

doi:10.1038/s41430-017-0013-x

Cited by 39 publications

(52 citation statements)

References 47 publications

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“…Although this study found no association between DII with other cardiometabolic risk factors as we expected, other studies also did not observe such an association [20,[50][51][52][53]. Noteworthy, the mean of the DII (0.15) of our sample did not characterize a pro-inflammatory diet in general, but in the ORISCAV-LUX study conducted with 1352 people they also did not present a pro-inflammatory diet in general [20].…”

Section: Discussioncontrasting

confidence: 78%

Dietary Inflammatory Index is Associated with Excessive Body Weight and Dietary Patterns in Subjects with Cardiometabolic Risk

Meneguelli¹,

Hinkelmann²,

Novaes³

et al. 2019

JFNR

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Unhealthy eating habits can trigger chronic inflammation in organs and tissues, and subsequent cardiovascular risk. Thus, this study aimed to evaluate the potential association of Dietary Inflammatory Index (DII™) score with cardiometabolic risk factors and a priori and a posteriori dietary patterns in adults and elderly Brazilians (42 ± 16 years) from a health care program. This cross-sectional study was carried out with 248 individuals (138 women and 110 men) from a Cardiovascular Health Care Program of the Universidade Federal de Viçosa (PROCARDIO-UFV, ReBEC ID number: RBR-5n4y2g). Sociodemographic and clinical characteristics, lifestyle and anthropometric data were assessed by standardized protocols. DII scores were calculated from a 24 h-recall, and dietary patterns were determined by a posteriori method, as Principal Component Analysis (PAC), and a priori method, as Healthy Eating Index (HEI). The mean DII was 0.15 ± 0.84. The subjects included in the most pro-inflammatory category(3rd tertile) were more likely to be individuals with excessive body weight, increased waist-to-hip ratio and lower quality diet assessed by PAC and HEI. The most pro-inflammatory diet was associated with excessive body weight as well as other worse dietary patterns.

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Section: Discussioncontrasting

confidence: 78%

Dietary Inflammatory Index is Associated with Excessive Body Weight and Dietary Patterns in Subjects with Cardiometabolic Risk

Meneguelli¹,

Hinkelmann²,

Novaes³

et al. 2019

JFNR

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“…The lack of association between the C-DII and IL-6 observed in this study may be due to the variability in IL-6 concentrations in our population, less sensitivity of this biomarker or due to ethnicity [57]. Results for this cytokine remain controversial in children; some studies in non-Hispanic children have also reported no associations [58] while others have reported a significant positive association [59]. Moreover, a recent study in Mexican adults found, over a period of 13 years, a positive association between the highest quartile of DII and the incidence of metabolic syndrome (HRQ4vsQ1 = 1.99; 95% CI: 1.03, 3.85; P-trend = 0.04), particularly associated with hypertriglyceridemia, hypertension and abdominal obesity [60].…”

Section: Discussioncontrasting

confidence: 58%

Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children

et al. 2020

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There is limited evidence about the inflammatory potential of diet in children. The aim of this study was to evaluate the association between the Children’s Dietary Inflammatory Index (C-DII) from 5 to 11 years with adiposity and inflammatory biomarkers in Mexican children. We analyzed 726 children from a birth cohort study with complete dietary information and measurements to evaluate adiposity at 5, 7 and 11 y and 286 children with IL-6, hsCRP, leptin and adiponectin information at 11 y. C-DII trajectories were estimated using latent class linear mixed models. We used linear mixed models for adiposity and logistic and multinomial regression for biomarkers. In girls, each one-point increase in C-DII score was associated with greater adiposity (abdominal-circumference 0.41%, p = 0.03; skinfold-sum 1.76%, p = 0.01; and BMI Z-score 0.05, p = 0.01). At 11 y the C-DII was associated with greater leptin (34% ≥ 13.0 ng/mL, p = 0.03) and hsCRP concentrations (29% ≥ 3.00 mg/L, p = 0.06) and lower adiponectin/leptin ratio (75% < 2.45, p = 0.02). C-DII trajectory 3 in boys was associated with a 75.2% (p < 0.01) increase in leptin concentrations and a 37.9% decrease (p = 0.02) in the adiponectin/leptin ratio. This study suggests that the inflammatory potential of diet may influence adiposity in girls and the homeostasis of adipose tissue and chronic subclinical inflammation in 11-year-old children.

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“…12 Furthermore, the dietary inflammatory index was previously used in Portuguese children. 23,24 Secondly, although the dietary definition. Similar to previous studies addressing the role of diet on asthma medication use, asthma medication includes both inhaled corticosteroids and short-acting bronchodilators.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is unlikely that most of the children with respiratory disease differentially adopt a pro‐inflammatory dietary pattern . Furthermore, the dietary inflammatory index was previously used in Portuguese children . Secondly, although the dietary inflammatory index has been calculated using the 24‐hour recall, not accounting for daily or seasonal variability in dietary patterns, this index was designed to be used with dietary data collected from different assessment methods, including the 24‐hour recall .…”

Section: Discussionmentioning

confidence: 99%

The inflammatory potential of diet impacts the association between air pollution and childhood asthma

Mendes

Paciência

Rufo

et al. 2020

Pediatric Allergy Immunology

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Background: Inhalation of fine particulate matter (PM) can cause systematic inflammation and oxidative stress, which may further aggravate the development and progression of asthma. Although nutritional intake of fatty acids and antioxidants may attenuate some effects of fine PM, the role of the inflammatory potential of diet has not been addressed. Therefore, we aimed to investigate possible modulatory effects of dietary inflammatory potential on the association between indoor air pollution and childhood asthma-related outcomes.Methods: In a sample of 501 children (48.1% females, aged 7-12 years) from 20 public schools located in Porto, Portugal, we evaluated airway reversibility, exhaled nitric oxide levels, atopy, and current respiratory symptoms. Dietary inflammatory index was calculated based on information collected through a reported 24-hour recall questionnaire, and participants were categorized as having an anti-inflammatory or pro-inflammatory diet. Concentrations of indoor PM2.5 and PM10 were measured to assess indoor air quality. Generalized linear mixed models were used to investigate the proportion of effects explained by the exposure to PM2.5 and PM10.Results: After adjustment, the exposure effect of PM2.5 and PM10 levels on children with asthma was higher for those having a pro-inflammatory diet (OR = 1.44, 95% CI:1.01-2.21; and OR = 1.29, 95% CI: 1.03-1.68, respectively) compared to those having an anti-inflammatory diet. Conclusion:These findings suggest that the quality of diet might affect the association between indoor pollution and asthma in children, highlighting the relevance | 291 de CASTRO MeNdeS eT Al. de CASTRO MeNdeS eT Al.effect was estimated by odds ratio (OR) and 95% confidence interval (95% CI). Additionally, β and 95% CI were estimated for continuous variables. Lung function parameters, exhaled NO, and all subjective and objective measures of asthma were included as outcomes, considering "medical diagnosis" and "under asthma treatment" as primary outcomes and "positive bronchodilation" and "asthma symptoms" as secondary outcomes. The values of DII were grouped into one of the two categories according to the inflammatory potential of the diet: anti-inflammatory, when the values were below zero; and pro-inflammatory, when the values were higher. Shivappa et al's review pointed out 45 food parameters, and they were scored with +1, −1, or 0 according to their inflammatory effects: pro, anti, or null, respectively. Accordingly, we aggregated children based on their proor anti-inflammatory individual DII score. 17 No children obtained an individual score equal to 0. The estimates were assessed in several models: a model for main effects (Model 1); a model considering an interaction between PM2.5 or PM10 and dietary inflammatory index (Model 2); and a model adjusted for age, sex, exposure to tobacco at home, maternal smoking during pregnancy, atopy, body mass categories, and school (Model 3). Model 3 considered the interaction only if it was significant in Model 2. A 0.05 level of signi...

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Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

Cited by 39 publications

References 47 publications

Dietary Inflammatory Index is Associated with Excessive Body Weight and Dietary Patterns in Subjects with Cardiometabolic Risk

Dietary Inflammatory Index is Associated with Excessive Body Weight and Dietary Patterns in Subjects with Cardiometabolic Risk

Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children

The inflammatory potential of diet impacts the association between air pollution and childhood asthma

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