Dietary intake and nutritional status of micronutrients in adults with cystic fibrosis in relation to current recommendations

Li, Li; Somerset, Shawn

doi:10.1016/j.clnu.2015.06.004

Cited by 15 publications

(10 citation statements)

References 86 publications

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“…With reference to micronutrients, mineral intakes have not received adequate attention in CF, in contrast with the fat-soluble vitamins, which are routinely assessed in serum and supplemented orally [ 52 , 53 ]. Our patients exhibited comparable micronutrient intake with an Australian pediatric cohort of CF [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Adherence to Dietary Recommendations, Nutrient Intake Adequacy and Diet Quality among Pediatric Cystic Fibrosis Patients: Results from the GreeCF Study

et al. 2020

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Nutrition is an important component of cystic fibrosis (CF) therapy, with a high-fat diet being the cornerstone of treatment. However, adherence to the dietary recommendations for CF appears suboptimal and burdensome for most children and adolescents with CF, leading to malnutrition, inadequate growth, compromised lung function and increased risk for respiratory infections. A cross-sectional approach was deployed to examine the degree of adherence to the nutrition recommendations and diet quality among children with CF. A total of 76 children were recruited from Aghia Sophia’s Children Hospital, in Athens, Greece. In their majority, participants attained their ideal body weight, met the recommendations for energy and fat intake, exceeding the goal for saturated fatty acids consumption. Carbohydrate and fiber intake were suboptimal and most participants exhibited low or mediocre adherence to the Mediterranean diet prototype. It appears that despite the optimal adherence to the energy and fat recommendations, there is still room for improvement concerning diet quality and fiber intake.

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Section: Discussionmentioning

confidence: 99%

Adherence to Dietary Recommendations, Nutrient Intake Adequacy and Diet Quality among Pediatric Cystic Fibrosis Patients: Results from the GreeCF Study

et al. 2020

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“…Studies suggested that a decreased intraluminal concentration of bile salts is an important factor in the development of severe vitamin E deficiency [ 51 , 52 ]. In the present study, the significantly lower serum cholesterol concentrations in SF patients indicate compensatory hepatic bile acid synthesis from cholesterol [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fat-Soluble Vitamins A, D, E and K on Vitamin Status and Metabolic Profile in Patients with Fat Malabsorption with and without Urolithiasis

et al. 2020

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Patients with intestinal fat malabsorption and urolithiasis are particularly at risk of acquiring fat-soluble vitamin deficiencies. The aim of the study was to evaluate the vitamin status and metabolic profile before and after the supplementation of fat-soluble vitamins A, D, E and K (ADEK) in 51 patients with fat malabsorption due to different intestinal diseases both with and without urolithiasis. Anthropometric, clinical, blood and 24-h urinary parameters and dietary intake were assessed at baseline and after ADEK supplementation for two weeks. At baseline, serum aspartate aminotransferase (AST) activity was higher in stone formers (SF; n = 10) than in non-stone formers (NSF; n = 41) but decreased significantly in SF patients after supplementation. Plasma vitamin D and E concentrations increased significantly and to a similar extent in both groups during intervention. While plasma vitamin D concentrations did not differ between the groups, vitamin E concentrations were significantly lower in the SF group than the NSF group before and after ADEK supplementation. Although vitamin D concentration increased significantly in both groups, urinary calcium excretion was not affected by ADEK supplementation. The decline in plasma AST activity in patients with urolithiasis might be attributed to the supplementation of ADEK. Patients with fat malabsorption may benefit from the supplementation of fat-soluble vitamins ADEK.

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“…Fat soluble vitamins (A, D, E and K) are coabsorbed with fat and thus deficiency of these vitamins may occur (Dodge 2006). Most CF centres now routinely administer these vitamins as supplements from the neonatal period, but the recommendations di er among the major CF centres (Li 2016). In the past, a few centres have administered them only later in life or when deficiencies are detected clinically or on routine monitoring.…”

Section: Description Of the Conditionmentioning

confidence: 99%

“…For vitamin A, Gri iths has termed this the 'vitamin A paradox' as vitamin A supplementation is likely to be "protective against pneumonia in malnourished children (who are likely to be vitamin A-deficient) and is paradoxically detrimental for adequately nourished children" (Gri iths 2000). Vitamin A supplementation following current regimens leads to adequate intake levels of vitamin A, but levels exceeding the recommended upper level are not uncommon (Brei 2013;Graham-Maar 2006;Li 2016;Maqbool 2008). Thus, some have called for individualised supplementation based on annual measurements rather than a fixed dosage, as is currently recommended in most CF guidelines (Borowitz 2002; Royal Brompton Hospital 2017; Saxby 2017).…”

Section: Agreements and Disagreements With Other Studies Or Reviewsmentioning

confidence: 99%

Vitamin A and beta (β)-carotene supplementation for cystic fibrosis

Vries¹,

Chang

Bonifant

et al. 2018

Cochrane Database of Systematic Reviews

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Since no randomised or quasi-randomised controlled studies on retinoid supplementation were identified, no conclusion on the supplementation of vitamin A in people with CF can be drawn. Additionally, due to methodological limitations in the included study, also reflected in the low-quality evidence judged following the specific evidence grading system (GRADE), no clear conclusions on β-carotene supplementation can be drawn. Until further data are available, country- or region-specific guidelines regarding these practices should be followed.

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Dietary intake and nutritional status of micronutrients in adults with cystic fibrosis in relation to current recommendations

Cited by 15 publications

References 86 publications

Adherence to Dietary Recommendations, Nutrient Intake Adequacy and Diet Quality among Pediatric Cystic Fibrosis Patients: Results from the GreeCF Study

Adherence to Dietary Recommendations, Nutrient Intake Adequacy and Diet Quality among Pediatric Cystic Fibrosis Patients: Results from the GreeCF Study

Effect of Fat-Soluble Vitamins A, D, E and K on Vitamin Status and Metabolic Profile in Patients with Fat Malabsorption with and without Urolithiasis

Vitamin A and beta (β)-carotene supplementation for cystic fibrosis

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