Dietary intake and nutritional status in patients with systemic lupus erythematosus

Pocovi-Gerardino, Gabriela; Correa‐Rodríguez, María; Callejas‐Rubio, José Luis; Ríos-Fernández, Raquel; Ortego-Centeno, Norbérto; Rueda‐Medina, Blanca

doi:10.1016/j.endinu.2018.05.009

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…Our findings related to nutrient consumption deficiencies in SLE patients have a similar pattern to that reported in a study conducted by Pocovi-Gerardino et al [43], where SLE patients did not reach the recommended intake for the Spanish population for iron (88%), calcium (65.2%), iodine (92.4%), potassium (73.9%), magnesium (65%), folate (72.8%) and vitamins E (87%) and D (82.6%) [43], and in a similar way to our findings, the SLE patients exceeded the recommendations for phosphorus and sodium.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies conducted in other populations of SLE patients supported these findings in our study; it has been reported that SLE patients present a high frequency of overweight and obesity, and the prevalence of excess weight (BMI > 25 kg/m 2 ) in the majority of studies conducted in SLE patients varies from 56 to 67% [10,11,14,16,17]. In Brazilian SLE patients two studies evaluating their nutritional status, reported a prevalence of excess weight from 62.4% to 64.1% [6,11], and in Spanish SLE patients the prevalence reported is of 43.5% with the presence of nutritional deficiencies [43]. Another study reported that 67% of SLE Polish patients are with excess weight, and carry higher concentrations of inflammatory markers such as C-reactive protein (CRP), in comparison with normal-weight patients [44].…”

Section: Discussionmentioning

confidence: 99%

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Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

et al. 2019

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Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional status and dietary intake with clinical variables in Mexican-mestizo SLE patients. A cross-sectional study was conducted in 130 female SLE patients, classified by the 1997 SLE American College of Rheumatology (ACR) criteria; the clinical activity was evaluated by the Mexican-Systemic Lupus Erythematosus-Disease Activity Index (Mex-SLEDAI); body mass index (BMI) by the World Health Organization (WHO) criteria; the energy calculation and nutritional intake were performed by Nutritionist Pro Diet software. SLE patients with excess weight (BMI > 25 kg/m2) showed a higher score of clinical activity (Mex-SLEDAI = 2; p = 0.003), higher clinical activity prevalence (40.9%; p = 0.039) and a significant association for high clinical activity (odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.08–5.9; p = 0.033), in comparison with patients without excess weight (BMI < 25 kg/m2). In particular, the excess weight increased the Mex-SLEDAI score (β coefficient = 1.82; R2 = 0.05; p = 0.005). Also, the SLE patients presented a high prevalence (%) of deficient consumption (cut-off point: <67% of dietary adequacy) of vitamin E (100%), iodine (96%), omega 3 (93.44%), biotin (78%), vitamin K (73.33%), iron (67%), vitamin D (63.3%), potassium (59%), folic acid (56.67%), pantothenic acid (43.3%), vitamin A (41.67%) and zinc (32%). In conclusion, in SLE patients the excess weight was associated with increased clinical activity and to the presence of deficiencies in some essential nutrients ingested.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

et al. 2019

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“…These multiple effects lead to the recovery and maintenance of immune homeostasis, and an overall protective effect in SLE patients ( 86 , 91 – 104 ). Although these observations justify the recommendation of vitamin D supplementation in SLE patients, the role of Vitamin D is not fully elucidated ( 105 – 107 ).…”

Section: Diet Effects On Slementioning

confidence: 99%

Life factors acting on systemic lupus erythematosus

et al. 2022

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Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. Currently, in the search for the mechanisms of SLE pathogenesis, the association of lifestyle factors such as diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption with SLE susceptibility has been systematically investigated. The cellular and molecular mechanisms mediating lifestyle effects on SLE occurrence, including interactions between genetic risk loci and environment, epigenetic changes, immune dysfunction, hyper-inflammatory response, and cytotoxicity, have been proposed. In the present review of the reports published in reputable peer-reviewed journals and government websites, we consider the current knowledge about the relationships between lifestyle factors and SLE incidence and outline directions of future research in this area. Formulation of practical measures with regard to the lifestyle in the future will benefit SLE patients and may provide potential therapy strategies.

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“…Известно, что диета, богатая сложными углеводами и пищевыми волокнами, приводит к потере веса в группе людей с высоким риском СД 2-го типа [26]. Однако у пациентов с СКВ потребление пищевых волокон часто низкое и не соответствует рекомендованному уровню [27,28].…”

Section: материал и методыunclassified

“…HAQ (r=0,28, p=0,002), СРБ (r=0,27, p=0,004), отрицательная корреляция между суммарным счетом и SLEDAI-2K (r=-0,25, p=0,005). Подобные корреляции наблюдались также между числом ФР и SLICC (r=0,35, p=0,0001), HAQ (r=0,18, p=0,051), СРБ (r=0,26, p=0,005), SLEDAI-2K (r=-0,25, p=0,006).Факт приема и суточная доза ГК в момент включения пациентов в исследование не влияли на число ФР и распределение по группам риска развития СД 2-го типа, но бóльшая длительность применения ГК ассоциировалась с увеличением числа ФР (r=0,22, p=0,02) и с тенденцией к нарастанию суммарного счета по FINDRISС (r=0,18, р=0,054).При СКВ медиана возраста в группе «низ кого»/ «слегка повышенного» риска СД составляла 36[30; 43] лет, в группе «умеренного», «высокого» и «очень высокого» риска -47 [39; 57] лет (р<0,001), доля больных младше 45 лет -79,8 и 42,9% соответственно (р=0,0001).…”

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Type II diabetes mellitus risk assessment using FINDRISC questionnaire in systemic lupus erythematosus patients

Кондратьева¹,

Попкова²

2020

Naučno-praktičeskaâ revmatologiâ

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Objective. To evaluate the prevalence of traditional risk factors in systemic lupus erythematosus (SLE) patients, assess the 10-years risk of developing type 2 diabetes mellitus (DM) in SLE patients and identify those necessitating preventive interventions following altered glucose metabolism using the Finnish Type 2 Diabetes Risk Score (FINDRISK) questionnaire.Materials and methods. The study included 119 SLE patients (107 women, 12 men, with median age 39 [33; 47] years and mean disease duration 6 [1,12] years.The control group included 100 age and sex matched individuals without immune-mediated inflammatory rheumatic diseases and without previous DM history. The 10-years risk of developing type 2 DM in SLE patients and the controls assessed using the Russian adaptation of Finnish Type 2 Diabetes Risk Score questionnaire. Fasting glucose levels in venous blood were measured in all SLE patients. Glucose levels ≥6.1 mmol/L were interpreted as fasting hyperglycemia.Results. The prevalence of traditional type 2 DM risk factors in SLE patients was as follows: abdominal obesity was found in 63.9%, lack of physical activity – in 62.2%, intake of antihypertensive drugs— in 52.9%, BMI ≥25 kg/m2 in 42.0%, unhealthy diets – in 40.3%, family history of DM – in 35.3%, age over 45 years – in 32.8%, history of hyperglycemia episodes – in 15.1%. Abdominal obesity and intake of antihypertensive drugs were more often documented in SLE patients, while all other risk factors were equally represented in SLE and control groups. On average 3 [2; 5] risk factors were found in each SLE patient. Low type 2 DM risk was a more rare phenomenon in SLE patients vs healthy controls (36.1 and 51%, р<0.05). Primary type 2 DM prophylaxis recommended in case of moderate, high and very high risk was more often indicated in SLE vs the healthy controls (29.4 and 17.0%, р=0.03), including those younger than 45 years (18.3 and 6.1% respectively, р=0.05). Fasting hyperglycemia was found in 1.2% patients with low-slightly increased type 2 DM risk and in 16.1% individuals with moderate, high and very high risk (p=0.04).Conclusions. High prevalence of such traditional type 2 DM risk factors as abdominal obesity, lack of physical activity and intake of antihypertensive drugs was demonstrated in SLE patients. Finnish Type 2 Diabetes Risk Score questionnaire identified moderate, high and very high 10-year risk of developing type 2DM in 29.4% SLE patients, necessitating prophylactic interventions in view of altered glucose metabolism.

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Dietary intake and nutritional status in patients with systemic lupus erythematosus

Cited by 16 publications

References 21 publications

Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

Life factors acting on systemic lupus erythematosus

Type II diabetes mellitus risk assessment using FINDRISC questionnaire in systemic lupus erythematosus patients

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