Dietary intake of a plant phospholipid/lipid conjugate reduces lung cancer growth and tumor angiogenesis

Abstract

It is well recognized that early detection and cancer prevention are significant armaments in the 'war against cancer'. Changes in lifestyle and diet have significant impact on the global incidence of cancer. For over 30 years, many investigators have studied the concept of chemoprevention. More recently, with the demonstration that antiangiogenic activity reduces tumor growth, the concept of angioprevention has emerged as a novel strategy in the deterrence of cancer development (carcinogenesis). In this study, we utilized a fast growing, highly aggressive murine Lewis lung cancer model to examine the in vivo antitumor effects of a novel, dietary supplement, known as plant phospholipid/lipid conjugate (pPLC). Our goal was to determine if pPLC possessed direct antitumor activity with relatively little toxicity that could be developed as a chemoprevention therapy. We used pPLC directly in this in vivo model due to the lack of aqueous solubility of this novel formulation, which precludes in vitro experimentation. pPLC contains known antioxidants, ferulic acid and lipoic acid, as well as soy sterols, formulated in a unique aqueous-insoluble matrix. The pPLC dietary supplement was shown to suppress in vivo growth of this tumor model by 30%. We also demonstrated a significant decrease in tumor angiogenesis accompanied by increased apoptosis and present preliminary evidence of enhanced expression of the hypoxia-related genes pentraxin-3 and metallothionein-3, by 24.9-fold and 10.9-fold, respectively, compared with vehicle control. These findings lead us to propose using this plant phosolipid/lipid conjugate as a dietary supplement that may be useful in cancer prevention.

Activation of Angiogenesis Differs Strongly Between Pulmonary Carcinoids and Neuroendocrine Carinomas and Is Crucial for Carcinoid Tumourgenesis

“…Another dietary supplement the plant phospholipid/lipid conjugate (pPLC) was used as a water soluble formulation and it was observed to reduce by 30% tumour growth in vivo. The pPLC contains antioxidants that also enhanced the expression of hypoxia-related genes pentraxin-3 and metallothionein-3 40 . Furthermore; the following pathways; a: STAT1 and STAT3 have been investigated as possible targets for blocking angiogenesis.…”

Ferulic acid promoting apoptosis in human osteosarcoma cell lines

“…Recently, numerous literatures have demonstrated the antitumor activities and protective effects of FA on thyroid cancer, prostate cancer, skin carcinogenesis, lung cancer, etc 6-9. Whereas the antitumor activities and its mechanism of FA in osteosarcoma remain still under discussion.…”

Nobiletin and xanthohumol counteract the TNFα‐mediated activation of endothelial cells through the inhibition of the NF‐κB signaling pathway

“…Many of these compounds received increasing attention as agents for cancer prevention but also for cancer therapy. These compounds exerts antioxidant, antiproliferative, and proapoptotic effects on a variety of cancer cells, including leukemia, prostate, breast, colon, brain, melanoma, and pancreas (W. W. Li et al, 2012; Quader et al, 2001; Rossi et al, 2014; Shuman Moss et al, 2014; Tosetti et al, 2009).…”

“…Natural compounds and natural plant‐derived metabolites are promising alternative prevention and cancer therapy strategies due to their antiproliferative or proapoptotic effects (W. W. Li et al, 2012; Rossi et al, 2014; Shuman Moss et al, 2014). Several publications showed the chemopreventive activity of natural compounds such as epigallocatechin‐3‐gallate, quercetin, and resveratrol (Alam et al, 2022; H. Guo et al, 2013; Jiang et al, 2020; Ward et al, 2018; H. Wu et al, 2019; J. Wu et al, 2014).…”