Dietary Intake of Polyphenols or Polyunsaturated Fatty Acids and Its Relationship with Metabolic and Inflammatory State in Patients with Type 2 Diabetes Mellitus

Abstract

Background: The aim of the study was to evaluate the relationship between polyphenol or polyunsaturated fatty acids (PUFAs) consumption and the selected metabolic and inflammatory markers in type 2 diabetes (T2DM) patients. Methods: The study enrolled 129 diabetics (49 men, mean age 64.1 ± 9.8 years) with different amounts of polyphenol and PUFAs consumption. Results: A significant effect of polyphenol or PUFAs omega-3 consumption on fasting glucose concentration (FG) or glycated haemoglobin fraction (HbA1c) was reported. A negative association was observed between FG and total polyphenol, flavonoid, flavan-3-ol and stilbene intake. In the group with high flavonoid intake, the FG was significantly lower compared to the group characterised by low flavonoid intake. Polyphenols, except stilbenes, did not modulate HbA1c. Additionally, higher consumption of PUFAs omega-3 significantly decreased HbA1c, and the intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids negatively and significantly correlated with FG and HbA1c. Further analysis confirmed a significant association between EPA + DHA intake and HbA1c, with significant interactions with age and gender or with body mass index and waist-to-hip ratio. The dietary intake of polyphenols or PUFAs was independent of familial diabetes or diabetic diet application. Conclusions: Our study indicates a positive effect of high consumption of flavonoids, omega-3 PUFAs and stilbenes on the markers of carbohydrate metabolism balance and the absence of such an effect on other cardiometabolic markers and inflammatory conditions.

Association of coffee consumption with type 2 diabetes and glycemic traits: a Mendelian randomization study

“…The pathophysiology of the inverse coffee consumption-T2D association can be explained in the following ways. First, coffee is a repository of phenolic compounds rich in antioxidant activity [ 49 50 ], protective against inflammation [ 51 52 ] and neurodegenerative diseases, including T2D, in some observational studies [ 53 54 ], intervention trials [ 55 ], and reviews [ 50 56 57 ]. Second, suppressed fat accumulation due to the inhibitive potential of quinic acids from phenols on the nuclear activity of sterol regulatory element-binding protein 1c, acetyl-CoA carboxylase activity, and cellular malonyl-CoA levels were reported in C57BL/6J mice on a high-fat diet supplemented with coffee-derived phenols [ 58 ].…”

Comparative Analysis of Biomarkers in Type 2 Diabetes Patients with and without Comorbidities: Insights into the Role of Hypertension and Cardiovascular Disease

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