Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study

Yamagishi, Kazumasa; Iso, Hiroyasu; Yatsuya, Hiroshi; Tanabe, Naohito; Date, Chigusa; Kikuchi, Shogo; Yamamoto, Akio; Inaba, Yutaka; Tamakoshi, Akiko

doi:10.3945/ajcn.2009.29146

Cited by 88 publications

(65 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a recent meta-analysis of prospective studies failed to show significant evidence to conclude that dietary SFA is associated with an increased risk of CAD 45) . The JACC Study Group have recently reported that no multivariable-adjusted association was observed between saturated fatty acid intake and mortality from heart disease [n 836; 0.89 (0.68, 1.15); P for trend 0.59] after 14.1-year follow-up of 58,453 Japanese middle-aged men and women 46) , although the distribution of saturated fatty acid intake among Japanese is far lower than that among Americans.…”

Section: Saturated Fatty Acidsmentioning

confidence: 99%

Japanese Dietary Lifestyle and Cardiovascular Disease

Tada

Maruyama

Koba

et al. 2011

JAT

View full text Add to dashboard Cite

To demonstrate the reasons for low morbidity and mortality from coronary artery disease (CAD) and reconfirm the effectiveness of the Japanese dietary lifestyle for preventing CAD, we herein review the CAD risk transition, and post-war changes in Japanese food and nutrient intake. Large-scale cohort studies in Japan were selectively reviewed. Low serum total cholesterol contributed to preventing CAD, and decreased blood pressure was the major factor favoring stroke reduction. Japanese consumed more plant and marine origin foods, but fewer animal foods with saturated fatty acids (SFA) during the 1960-70s than in recent decades. Adequate control of total energy with restriction of saturated fatty acids from animal foods, increased intake of n-3 polyunsaturated fatty acids, including fish, soybean products, fruits and vegetables together with low salt intake are responsible for promoting CAD and stroke prevention. A diet with adequate total calories and increased intake of fish and plant foods, but decreased intake of refined carbohydrates and animal fat, a so-called Japan diet, appears to be quite effective for prevention of CAD risk factors and is recommended as dietary therapy for preventing CAD. J Atheroscler Thromb, 2011; 18:723-734.

show abstract

Section: Saturated Fatty Acidsmentioning

confidence: 99%

Japanese Dietary Lifestyle and Cardiovascular Disease

Tada

Maruyama

Koba

et al. 2011

JAT

View full text Add to dashboard Cite

show abstract

“…A dietary study of 80,082 women in the US Nurses' Health Study, aged 34-59 years, with a 14-year follow-up, failed to come up with an unambiguous conclusion on the link between saturated fat and CHD (Hu et al, 1999). A study involving 58,453 Japanese men and women, aged 40-79 years, with a 14-year followup, gave an inverse association between SFA intake and mortality from total cardiovascular disease and concluded that replacing SFA with PUFA would have no benefit for the prevention of heart disease (Yamagishi et al, 2010).…”

Section: Keys Failed To Prove His Saturated Fat-cholesterol-heart Dismentioning

confidence: 99%

The Warning on Saturated Fat: From Defective Experiments to Defective Guidelines

Dayrit¹

2017

KIMIKA

View full text Add to dashboard Cite

Coconut oil has been adversely affected by the current dietary guidelines that advocate a lowering of total fat and the replacement of saturated fat with polyunsaturated fat. This recommendation has its origins in the saturated fat-cholesterol-heart disease hypothesis that Ancel Keys first proposed in 1957. This hypothesis became an official recommendation with the publication of the Dietary Guidelines for Americans in 1980 and has been adopted by many other countries and international agencies. The dietary recommendations also warn against coconut oil. Recently, the American Heart Association re-issued this warning in its 2017 Presidential Advisory. However, a critical review of the experiments that Keys conducted has revealed experimental errors and biases that cast serious doubt on the correctness of his hypothesis and the warnings against coconut oil. Further, the recommendation to decrease saturated fat recommendation effectively means an increase in unsaturated fat in the diet. The actual result has been an increase in omega-6 fats and a high omega-6 to omega-3 fat ratio. This unhealthy ratio has been linked to heart disease, the very disease that the AHA wants to target, as well as cancer and inflammatory diseases. Defective experiments have led to defective guidelines. This first paper in this series of papers will present these errors and biases and address the points raised by the AHA.

show abstract

“…In Fig. 1 in the present paper, we plotted the proportion of saturated fat relative to the total energy intake instead of the absolute amount based on the published literature 12, [14][15][16][18][19][20][21][22] . Consequently, there appears to be a threshold for saturated fat intake of around 7.5% to 10% of the total energy for the inverse relationship between saturated fat intake and the risk of stroke, especially with respect to intraparenchymal hemorrhage, consistent with that observed for the absolute amount of energy (15 to 20 g/day assuming a total energy intake of 1,800 kcal) 16) .…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…However, considering that the range of saturated fat intake is significantly different between Western countries and Asia, it is inappropriate to directly apply the results of these meta-analyses to Japan, as they include many Western studies. Therefore, we focused on six cohort studies of Japanese population [12][13][14][15][16][17] . A summary of these studies is presented in Table 1.…”

mentioning

confidence: 99%

“…In contrast, we found a positive association between saturated fat intake and myocardial infarction (hazard ratio [confidence interval] 1.39 [0.93-2.08] for the highest versus lowest quintiles, p for trend 0.046), the first epidemiological observaassociation was observed between saturated fat intake and the incidence or mortality of ischemic stroke. In the Japan Collaborative Cohort (JACC) Study, a strong inverse association was noted between saturated fat intake and mortality from both ischemic stroke and intraparenchymal hemorrhage 15) . In the Japan Public Health Center-based Prospective Study (JPHC Study), a large community-based cohort of 81,931 Japanese men and women, we found an inverse association between saturated fat intake and the risk of incident intraparenchymal hemorrhage and ischemic stroke; the hazard ratio [95% confidence , ages 34-59, women only, US; HPFS: Health Professional Follow-up Study 19,20) , ages 40-75, men only, US; CIRCS: Circulatory Risk in Communities Study 12) , ages 40-69, men:women 48:52, Japan; JPHC; Japan Public Health Center-based Prospective Study 16) , ages 45-74, men:women 46:54, Japan; JACC; Japan Collaborative Cohort Study 15) , ages 40-79, men:women 39:61, Japan; LSS: Life Span Study 14) , ages 35-89, men:women 38:62, Japan; ATBC: Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study 22) , ages 50-69, male smokers only, Finland; SHS: Strong Heart Study 21) , ages 47-79, men:women 36:64, US.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Saturated Fat Intake and Cardiovascular Disease in Japanese Population

Yamagishi

Iso

Tsugane

2015

J Atheroscler Thromb

Self Cite

View full text Add to dashboard Cite

The evidence for the impact of saturated fat intake on cardiovascular disease remains inconsistent. One reason for this inconsistency may be the large difference in the distribution of saturated fat intake between the East and West. In this review, we focus on the published literature on this topic among Japanese population. Three studies have examined the link between saturated fat intake and intraparenchymal hemorrhage, consistently showing an inverse association. However, the association for ischemic stroke is less clear, although it is generally inverse. As for myocardial infarction, the findings in Japanese studies are inconsistent, as are those of Western studies. The JPHC study, however, found a positive association, the first report in Asia. Taken

show abstract

Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study

Cited by 88 publications

References 36 publications

Japanese Dietary Lifestyle and Cardiovascular Disease

Japanese Dietary Lifestyle and Cardiovascular Disease

The Warning on Saturated Fat: From Defective Experiments to Defective Guidelines

Saturated Fat Intake and Cardiovascular Disease in Japanese Population

Contact Info

Product

Resources

About