Dietary intake of selected nutrients and persistence of HPV infection in men

Abstract

Human papillomavirus (HPV) infection is a common sexually transmitted disease. Although often transitory, persistent oncogenic HPV infection may progress to a precursor lesion and, if not treated, can further increase the risk of cancer. The purpose of this study was to investigate the relation between dietary intake and HPV persistent infection in men of a Brazilian cohort. The study population consisted of 1,248 men from the Brazilian cohort of the HIM (HPV in Men) Study, ages 18 to 70 years, who completed a quantitative food frequency questionnaire. U Mann-Whitney test was used to assess differences in median nutrient intake of selected nutrients. The association of dietary intake and persistent HPV infection was assessed in multivariate logistic models. The prevalence of any HPV infection at baseline was 66.6%. Of 1,248 participants analyzed, 1,211 (97.0%) were HPV positive at one or more times during the 4 years of follow-up and 781 (62.6%) were persistently HPV positive. Men with nonpersistent oncogenic HPV infections had higher median intake of retinol (p = 0.008), vitamin A (p < 0.001) and folate (DFE; p = 0.003) and lower median intake of energy (p = 0.005) and lycopene (p = 0.008) in comparison to men with persistent oncogenic infections. No significant association was found between selected nutrients and persistent oncogenic HPV infection. For nononcogenic persistent infections, only vitamin B12 intake was significantly associated (p = 0.003, test for trend). No association was observed between dietary intake and persistent oncogenic-type HPV infection; however, vitamin B12 intake was inversely associated with nononcogenic HPV persistence.

Added sugar and trans fatty acid intake and sedentary behavior were associated with excess total‐body and central adiposity in children and adolescents with congenital heart disease

“…For entering the 24‐hour recall data in the NDSR software, the standardized methodological for dietary intake assessment was used. Several studies that evaluated food intake in Brazil have used NDSR to assess dietary intake To adjust dietary intake for intra‐and‐interpersonal variability with the intention to reduce information bias (adjusting variability for day of the week, sex, age, mother's education, BMI, and per capita income) and to estimate individual's usual food intake, it was used the method developed by the Iowa State University . Moreover, all nutrients were adjusted for total energy .…”

Evaluation of Oral Supplementation with a Casein Hydrolysate-based Formula to Favor the Clearance of HR-HPV Infections and their Derived Lesions

“…Deficiencies of carotenoids such as vitamin A are clearly associated with the onset of cervical cancer and its precursor lesions, and folate deficiencies are related to the occurrence of pre-cancerous lesions of the cervix [17]. In a study conducted on 1,248 men with HPV infection, it was observed that patients who consumed more retinol, vitamin A and folates had a lower persistence of HPV infections [16]. Folates could play a role in regulating the integration and stability of the viral genome, thanks to its involvement in DNA synthesis, repair and methylation [15,29].…”

“…In parallel, HPVs can be classified as low risk (LR-HPV) or high-risk viruses (HR-HPV), depending on the risk of developing cancer by their infection persistence [2]. In this sense, fifteen HPV types are considered high-risk types (16,18,31,33,35,39,45,51,52,56,58,59,68,73, and 82) while 3 are classified as probable high-risk types (26,53, and 66) [3].…”

“…Inclusion criteria: Patients with positive DNA test for at least one HR-HPV (HPV 16,18,26,31,33,35,39,45,51,52,53,56,58,59,66,68,73,82) with normal, ASCUS or LSIL cytology. Women from 20 to 65 years old.…”

“…The specific casein hydrolysate is a mixture of dipeptides and tripeptides that are source of fast systemic absorption amino acids and bioactive peptides. This formula is combined with vitamins (Vitamin A, B3 and B9) and minerals (zinc) whose dietary deficiencies have been related to a greater persistence of HPV infections and progression of the derived lesions [15][16][17][18][19][20].…”