Dietary Intervention in Infancy and Cognitive Function in Young Adulthood: The Special Turku Coronary Risk Factor Intervention Project

Rovio, Suvi; Salo, Henri; Niinikoski, Harri; Lagström, Hanna; Salo, Pia; Viikari, Jorma; Rönnemaa, Tapani; Jula, Antti; Raitakari, Olli T.; Pahkala, Katja

doi:10.1016/j.jpeds.2022.03.046

Cited by 5 publications

(8 citation statements)

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“…However, excessive intake of red meat also gives rise to abnormalities in lipid metabolism, inflammatory reactions and possibly chronic diseases (6). Serum total cholesterol levels change if there is excessive consumption of cholesterol and saturated fats, and high levels of serum cholesterol accumulates in macrophages and then activates the NLRP3 inflammasome through the NF-κB signaling pathway (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to lipoproteins, oxidized lipids (ox-LDL) are considered to have a much stronger influence on inflammation; ox-LDL can not only be synthesized endogenously but can also be obtained through the diets (18). Therefore, inhibiting proinflammatory cytokines has emerged as a novel promising mode of therapy to improve and complement the current lipidlowering approaches (7).…”

Section: Introductionmentioning

confidence: 99%

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Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Sun

Yuan

Chen

et al. 2022

Front. Cardiovasc. Med.

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AimThe study (PROSPERO: CRD42021240905) aims to reveal the relationships among red meat, serum lipids and inflammatory biomarkers.Methods and resultsPubMed, EMBASE and the Cochrane databases were explored through December 2021 to identify 574 studies about red meat and serum lipids markers including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP) or hypersensitive-CRP (hs-CRP). Finally, 20 randomized controlled trials (RCTs) involving 1001 people were included, red meat and serum lipid markers and their relevant information was extracted. The pooled standard mean difference (SMD) was obtained by applying a random-effects model, and subgroup analyses and meta-regression were employed to explain the heterogeneity. Compared with white meat or grain diets, the gross results showed that the consumption of red meat increased serum lipid concentrations like TG (0.29 mmol/L, 95% CI 0.14, 0.44,P<0.001), but did not significantly influence the TC (0.13 mmol/L, 95% CI −0.07, 0.33, P = 0.21), LDL-C (0.11 mmol/L, 95% CI −0.23, 0.45, P = 0.53), HDL-C (−0.07 mmol/L, 95% CI −0.31, 0.17, P = 0.57),CRP or hs-CRP (0.13 mmol/L, 95% CI −0.10, 0.37,P = 0.273).ConclusionOur study provided evidence to the fact that red meat consumption affected serum lipids levels like TG, but almost had no effect on TC, LDL-C, HDL-C and CRP or hs-CRP. Such diets with red meat should be taken seriously to avoid the problem of high lipid profiles.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO], identifier [CRD42021240905].

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Sun

Yuan

Chen

et al. 2022

Front. Cardiovasc. Med.

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“…27 Out of the cohort of 1116 individuals, 1072 were invited to participate, and of these, 551 provided follow-up data (51%). 25 In the prior attrition analyses, those attending to the follow-up visit did not differ from those not attending in terms of parental socioeconomic status, health status, or health behaviors. 27 At the follow-up visit (n = 546), participants were inquired of their willingness to participate in a 1-week accelerometer measurement.…”

Section: Study Populationmentioning

confidence: 84%

“…The Special Turku Coronary Risk Factor Intervention Project (STRIP) study is a prospective, randomized controlled trial aiming to prevent atherosclerosis beginning in infancy 24 . A detailed description of the study design has been reported 24,25 . In brief, families of 5‐month‐old infants, born between July 1989 and December 1991, were recruited at well‐baby clinics in Turku, Finland by nurses.…”

Section: Methodsmentioning

confidence: 99%

“…24 A detailed description of the study design has been reported. 24,25 In brief, families of 5-month-old infants, born between July 1989 and December 1991, were recruited at well-baby clinics in Turku, Finland by nurses. At the age of 7 months, 1062 infants (57% of the eligible age-cohort) were randomly allocated to either a dietary intervention (n = 540) or control (n = 522) group.…”

Section: Study Populationmentioning

confidence: 99%

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Weekday and weekend physical activity patterns and their correlates among young adults

Suorsa,

Leskinen,

Rovio

et al. 2023

Scandinavian Med Sci Sports

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BackgroundAccelerometers enable assessment of within and between day variation in physical activity. The main aim was to examine weekday and weekend physical activity patterns among young adults. Additionally, correlates of the physical activity patterns were examined.MethodsOverall 325 adults (mean age 26.0 years, standard deviation 0.03) from the Special Turku Coronary Risk Factor Intervention Project used a wrist‐worn ActiGraph accelerometer continuously for 1 week. Physical activity patterns over weekdays and weekends were identified by using the group‐based trajectory modeling. Adolescent leisure time physical activity (LTPA) and sociodemographic characteristics (sex, marital and family status, education, work status, occupation, and health consciousness) were examined as possible correlates of physical activity patterns using multinomial regression analysis.ResultsFive patterns were identified: consistently low activity (45%), active on weekday evenings and weekends (32%), consistently moderate activity (11%), active on weekdays (7%), and consistently high activity (5%). Low adolescent LTPA was associated with consistently low activity pattern in young adulthood. Women were more likely than men to belong in the more physically active groups (all other groups except active on weekdays, odds ratios between 2.26 and 6.17). Those in the active on weekdays group had lower education, were more often in the working life and in manual occupations than those in the consistently low activity group.ConclusionsMarked heterogeneity in physical activity patterns across the week was observed among young adults. Especially history of physical activity, sex, education, work status, and occupation were associated with different physical activity patterns.

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Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness

Meng,

Sharman,

Koskinen

et al. 2024

JAMA Pediatr

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ImportanceAlthough cardiovascular disease (CVD) begins in early life, the extent to which blood pressure (BP) at different life stages contributes to CVD is unclear.ObjectiveTo determine the relative contribution of BP at different life stages across the early-life course from infancy to young adulthood with carotid intima-media thickness (IMT).Design, setting, and participantsThe analyses were performed in 2022 using data gathered from July 1989 through January 2018 within the Special Turku Coronary Risk Factor Intervention Project, a randomized, infancy-onset cohort of 534 participants coupled with annual BP (from age 7 months to 20 years), biennial IMT measurements (from ages 13 to 19 years), who were followed up with again at age 26 years.ExposuresBP measured from infancy (aged 7 to 13 months), preschool (2 to 5 years), childhood (6 to 12 years), adolescence (13 to 17 years), and young adulthood (18 to 26 years).Main outcomes and measuresPrimary outcomes were carotid IMT measured in young adulthood at age 26 years. Bayesian relevant life-course exposure models assessed the relative contribution of BP at each life stage.ResultsSystolic BP at each life stage contributed to the association with young adulthood carotid IMT (infancy: relative weight, 25.3%; 95% credible interval [CrI], 3.6-45.8; preschool childhood: relative weight, 27.0%; 95% CrI, 3.3-57.1; childhood: relative weight, 18.0%; 95% CrI, 0.5-40.0; adolescence: relative weight, 13.5%; 95% CrI, 0.4-37.1; and young adulthood: relative weight, 16.2%; 95% CrI, 1.6-46.1). A 1-SD (at single life-stage) higher systolic BP accumulated across the life course was associated with a higher carotid IMT (0.02 mm; 95% CrI, 0.01-0.03). The findings for carotid IMT were replicated in the Cardiovascular Risk in Young Finns Study that assessed systolic BP from childhood and carotid IMT in adulthood (33 to 45 years).Conclusion and relevanceIn this cohort study, a life-course approach indicated that accumulation of risk exposure to BP levels at all life stages contributed to adulthood carotid IMT. Of those, the contribution attributed to each observed life stage was approximately equal. These results support prevention efforts that achieve and maintain normal BP levels across the life course, starting in infancy.

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Dietary Intervention in Infancy and Cognitive Function in Young Adulthood: The Special Turku Coronary Risk Factor Intervention Project

Cited by 5 publications

References 36 publications

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Weekday and weekend physical activity patterns and their correlates among young adults

Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness

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