Dietary L-theanine alleviated lipopolysaccharide-induced immunological stress in yellow-feathered broilers

Li, Rui; Song, Zehe; Zhao, Jingyuan; Huo, Dongxiao; Fan, Zhiyong; Hou, De‐Xing; He, Xiao-Yan

doi:10.1016/j.aninu.2018.05.002

Cited by 36 publications

(37 citation statements)

References 46 publications

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“…This effect has already been observed in other studies with broilers and is dependent on the LPS dose, number of applications, and time between application and weighing of the birds. For example, Li et al (2018), after applying 0.6 mg of LPS/kg of BW at 24, 25, and 26 days of age, observed a reduction of 15.4% in feed intake and of 16.2% in weight gain in the period of 22 to 28 days of age. Zhang et al (2020) observed that 24 h after the application of 5.0 mg of LPS/kg of BW at 21 days of age resulted in a 44.6% reduction in weight gain compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

“…This may be explained by changes in the partitioning of nutrients away from growth and toward processes associated with the acute-phase response. Lipopolysaccharide is a molecule present in the outer membrane of gramnegative bacteria and has commonly been used to induce an inflammatory response in broilers in experimental conditions (Lieboldt et al, 2017;Li et al, 2018;Zhang et al, 2020). Lipopolysaccharide injections induce the synthesis and release of pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6 (Yang et al, 2008), which activate neutrophils, monocytes, and macrophages to initiate killing of bacteria and tumor cells and stimulate T and B lymphocyte proliferation (Calder, 2001).…”

Section: Discussionmentioning

confidence: 99%

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Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge

Kreuz¹,

Rocha²,

Campos³

et al. 2020

Revista Brasileira De Zootecnia

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The objective of this study was to evaluate the effects of dietary nucleotide supplementation on growth performance, serum immunoglobulin G (IgG) and uric acid levels, immune-related organs, and intestinal morphometric parameters of broiler chickens under pre-and post-inflammatory challenge with lipopolysaccharide (LPS). Ninety-six seven-day-old male broiler chicks were randomized in a 2×2 factorial design composed of two dietary types (supplemented with 0 and 0.3 g of purified nucleotides/kg of feed) and two inflammatory conditions (with and without LPS administration) with eight replicates per treatment and three birds per cage. The experimental period was divided into two phases: 7-20 days of age (pre-LPS challenge) and 21-35 days of age (post-LPS challenge). Data were analyzed using one-way and two-way ANOVA for the pre-and post-challenge phases, respectively. During the prechallenge phase, dietary nucleotide supplementation improved body weight (982 vs. 1009 g/bird), daily weight gain (58.1 vs. 60.1 g/bird), feed conversion rate (1.28 vs. 1.25 g/g), and serum concentration of IgG (1.17 vs. 1.76 mg/mL) of broilers. During the post-challenge phase, nucleotide supplementation increased serum IgG of broilers at 28 days of age (3.01 vs. 4.34 mg/mL). For the intestinal morphometric parameters, nucleotide supplementation increased villus height (299.3 vs. 315.6 μm). Dietary nucleotide supplementation improves the performance of broilers from seven to 20 days of age (pre-LPS challenge). However, from 21 to 35 days of age, supplementation of 0.3 g of purified nucleotides/kg of feed, independent of inflammatory challenge, does not contribute to improve performance of broilers. Additionally, nucleotide supplementation increases IgG production and villus height in the jejunum of broilers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge

Kreuz¹,

Rocha²,

Campos³

et al. 2020

Revista Brasileira De Zootecnia

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“…LPS induction in vivo stimulated monocyte‐macrophage cell synthesis and resulted in the release of a large number of proinflammatory cytokines, such as IL‐1β, IL‐6 and TNF‐α, which promote metabolism and increase nutrient consumption, thereby resulting in the inhibition of animal growth and tissue damage (Li et al, ). In the immune system, proinflammatory cytokines are major cellular messengers, regulating the body's innate and adaptive immune response to antigens and infectious agents.…”

Section: Discussionmentioning

confidence: 99%

Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

Yang

Liu

Liang

et al. 2019

Animal Science Journal

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This study evaluated the effects of berberine on growth performance, immunity, haematological parameters, antioxidant capacity, and the expression of immune response‐related genes in lipopolysaccharide (LPS)‐challenged broilers. We assigned 120 one‐day‐old male broilers (Ross 308) to two treatment groups; each group included two subgroups, each of which included six replicates of five birds per replicate. The experiment used a 2 × 2 factorial arrangement with berberine treatment (0 or 60 mg/kg dietary) and challenge status [injection of saline (9 g/L w/v) or LPS (1.5 mg/kg body weight)] as the main factors. On days 14, 16, 18 and 20, broilers were intraperitoneally injected with LPS or physiological saline. Blood and liver samples were collected on day 21. Dietary berberine supplementation significantly alleviated the compromised average daily gain and average daily feed intake (p < 0.05) caused by LPS. The LPS challenge led to increased lymphocyte and white blood cell (WBC) counts, malondialdehyde (serum and liver) content, and immunoglobulin G and M, tumour necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) expression (p < 0.05) and significantly reduced serum total superoxide dismutase (T‐SOD) activity (p < 0.05). Dietary berberine significantly mitigated the LPS‐induced decreases in the mRNA expression of nuclear factor‐kappa B (NF‐κB), TNF‐α, IL‐1β, inducible nitrite synthase and cyclooxygenase‐2 (p < 0.05) in the liver. In conclusion, berberine supplementation has a positive effect on LPS challenge, which may be related to the increase in antioxidant enzyme activity and inhibition of both NF‐κB signalling and the expression of inflammatory mediators.

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“…Igs are glycoproteins and one of the vital components of the immune system and previous reports suggested a beneficial role of Igs in inflammatory response (Brimelow et al, 2015; Elluru et al, 2015; Li et al, 2018). In this study, we found that IgG involves in colonic colitis as TNBS significantly inhibited serum IgG production.…”

Section: Discussionmentioning

confidence: 99%

Matrine Mediates Inflammatory Response via Gut Microbiota in TNBS-Induced Murine Colitis

et al. 2019

Front. Physiol.

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This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation. Matrine (1, 5, and 10 mg/kg) treatment alleviated colonic injury and gut inflammation via reducing bleeding and diarrhea and downregulating cytokines expression (IL-1β and TNF-α). Meanwhile, serum immunoglobulin G (IgG) was markedly reduced in TNBS treated mice, while 5 and 10 mg/kg matrine alleviated IgG reduction. Fecal microbiota was tested using 16S sequencing and the results showed that TNBS caused gut microbiota dysbiosis, while matrine treatment markedly improved gut microbiota communities (i.e., Bacilli and Mollicutes). Functional analysis showed that cell motility, nucleotide metabolism, and replication and repair were markedly altered in the TNBS group, while matrine treatment significantly affected cell growth and death, membrane transport, nucleotide metabolism, and replication and repair. In conclusion, matrine may serve as a protective mechanism in TNBS-induced colonic inflammation and the beneficial effect may be associated with gut microbiota.

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Dietary L-theanine alleviated lipopolysaccharide-induced immunological stress in yellow-feathered broilers

Cited by 36 publications

References 46 publications

Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge

Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge

Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

Matrine Mediates Inflammatory Response via Gut Microbiota in TNBS-Induced Murine Colitis

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