Dietary Lipid Modulation of Myocardial (3-Adrenergic Mechanisms, Ca2+-Dependent Automaticity, and Arrhythmogenesis in the Marmoset

McLennan, Peter L; My, Abeywardena; Js, Charnock; Ej, McMurchie

doi:10.1097/00005344-198709000-00007

Cited by 19 publications

(1 citation statement)

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“…Numerous studies demonstrate that dietary lipids can both influence the phospholipid fatty acid composition of myocardial cells and modulate cardiac arrhythmia vulnerability. Diets rich in PUFA of plant (n-6) or marine (n-3) origin reduce the incidence of fatal cardiac arrhythmias generated by acute regional myocardial ischemia in rats (6)(7)(8)(9), by electrical stimulation and myocardial ischemia in the marmoset monkey (10), and by calcium or isoprenaline in isolated myocardial tissue (11,12). However, a comparison of the effects of fish oils and dietary vegetable oils indicates an enhanced antiarrhythmic effect of dietary fish oils beyond that attributable to their PUFA content alone ( Fig.…”

Section: Fish Oil and Cardiac Arrhythmiamentioning

confidence: 99%

Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models

McLennan¹

2001

Lipids

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125

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Epidemiologic studies, animal studies, and more recently, clinical intervention trials all suggest a role for regular intake of dietary fish oil in reducing cardiovascular morbidity and mortality. Prevention of cardiac arrhythmias and sudden death is demonstrable at fish or fish oil intakes that have little or no effect on blood pressure or plasma lipids. In animals, dietary intake of fish oil [containing both eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3)] selectively increases myocardial membrane phospholipid content of DHA, whereas low dose consumption of purified fatty acids shows antiarrhythmic effects of DHA but not EPA. Ventricular fibrillation induced under many conditions, including ischemia, reperfusion, and electrical stimulation, and even arrhythmias induced in vitro with no circulating fatty acids are prevented by prior dietary consumption of fish oil. The preferential accumulation of DHA in myocardial cell membranes, its association with arrhythmia prevention, and the selective ability of pure DHA to prevent ventricular fibrillation all point to DHA as the active component of fish oil. The antiarrhythmic effect of dietary fish oil appears to depend on the accumulation of DHA in myocardial cell membranes.

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Section: Fish Oil and Cardiac Arrhythmiamentioning

confidence: 99%

Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models

McLennan¹

2001

Lipids

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125

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Dietary modulation of lipid metabolism and mechanical performance of the heart

Charnock¹,

McLennan²,

Abeywardena³

1992

Lipid Metabolism in the Healthy and Disease Heart

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Sudden Cardiac Death resulting from sustained ventricular fibrillation or malignant cardiac arrhythmia has been linked to the type of dietary fat intake in several economically well developed countries where high levels of saturated fatty acids are common. Experimental studies with the small non-human primate marmoset monkey have clearly demonstrated the health benefit of substituting polyunsaturated fatty acids (PUFA's) for dietary saturated fatty acids. Heart rate and blood pressure are lowered, while the left ventricular ejection fraction and the electrical threshold for the induction of ventricular fibrillation are both increased after prolonged feeding of PUFA enriched diets. All these changes in heart function reduce the risk of developing malignant cardiac arrhythmias.The fatty acid composition of cardiac membrane phospholipids is profoundly altered by these changes in dietary lipid intake. In particular the proportions of arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are altered in such a way that the production of myocardial eicosanoids is affected. Although the changes in proportion of these long-chain PUFA's in cardiac phosphatidyl ethanolamine and phosphatidyl inositol are not identical, the shift in balance between these substrates or inhibitors of cyclo-oxygenase activity leads to relatively greater production of prostacyclin (PGI2) than thromboxane (TXA2).The effect of the omega-3 PUFA's of fish oil is proportionally greater than that of linoleic acid (LA; 18:2, c06) rich sunflower seed oil, particularly during ischaemia, and probably reflects the different nutritionally induced changes in cardiac membrane fatty acid composition by these different types of dietary PUFA's. (Mol Cell Biochem 116: 19-25, 1992).

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Vitamin E and Health in the Marmoset Monkey: A Non-Human Primate Model for Nutritional Research

Charnock¹,

Bridle²,

Turner³

et al. 1992

Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

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Dietary Lipid Modulation of Myocardial (3-Adrenergic Mechanisms, Ca2+-Dependent Automaticity, and Arrhythmogenesis in the Marmoset

Cited by 19 publications

References 0 publications

Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models

Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models

Dietary modulation of lipid metabolism and mechanical performance of the heart

Vitamin E and Health in the Marmoset Monkey: A Non-Human Primate Model for Nutritional Research

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