Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models

McLennan, Peter L

doi:10.1007/s11745-001-0692-x

Cited by 125 publications

(105 citation statements)

References 25 publications

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“…Fish consumption also appears to reduce risk of fatal ventricular arrhythmias, consistent with antiarrhythmic effects of long-chain n-3 polyunsaturated fatty acids in fish. [17][18][19][20][21][22][23][24] In cultured rat atrial myocytes, n-3 fatty acids reduce induced asynchronous contractile activity, 25 suggesting that n-3 fatty acids from fish may have antiarrhythmic effects on atrial muscle. However, it is unknown if fish intake-or indeed any dietary factor-influences risk of AF.…”

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Fish Intake and Risk of Incident Atrial Fibrillation

et al. 2004

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Background-Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated. Methods and Results-In a prospective, population-based cohort of 4815 adults Նage 65 years, usual dietary intake was assessed at baseline in 1989 and 1990. Consumption of tuna and other broiled or baked fish correlated with plasma phospholipid long-chain n-3 fatty acids, whereas consumption of fried fish or fish sandwiches (fish burgers) did not. AF incidence was prospectively ascertained on the basis of hospital discharge records and annual electrocardiograms. During 12 years' follow-up, 980 cases of incident AF were diagnosed. In multivariate analyses, consumption of tuna or other broiled or baked fish was inversely associated with incidence of AF, with 28% lower risk with intake 1 to 4 times per week (HRϭ0.72, 95% CIϭ0.58 to 0.91, Pϭ0.005), and 31% lower risk with intake Ն5 times per week (HRϭ0.69, 95% CIϭ0.52 to 0.91, Pϭ0.008), compared with Ͻ1 time per month (P trendϭ0.004). Results were not materially different after adjustment for preceding myocardial infarction or congestive heart failure. In similar analyses, fried fish/fish sandwich consumption was not associated with lower risk of AF. Conclusions-Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.

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Fish Intake and Risk of Incident Atrial Fibrillation

et al. 2004

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“…[108] This is possible due to the incorporation of DHA in the cell membrane, [109] influencing the eicosanoids mechanism and modulating cellular Ca 2+ and its signaling pathways.…”

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Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function

Calvo¹,

Martínez²,

Torres³

et al. 2017

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How to cite this article: Calvo MJ, Martínez MS, Torres W, Chávez-Castillo M, Luzardo E, Villasmil N, Salazar J, Velasco M, Bermúdez V. Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function. Vessel Plus 2017;1:116-28.Given the notorious impact of cardiovascular disease (CVD) as the current leading cause of mortality worldwide, the prevention, identification and management of CV risk factors represents a priority in daily clinical practice. Several studies have shown the beneficial effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on CV health. Their derivatives, eicosapentaenoic acid and docosahexaenoic acid, intervene in multiple metabolic pathways, including: regulation of the inflammatory response, by reducing the synthesis of pro-inflammatory cytokines; regulation of platelet aggregation, activation and adhesion, by modulating thromboxane A2 and plasminogen activator inhibitor-1 activity; regulation of the coagulation pathways, by reducing the carboxylation of vitamin K-dependent coagulation factors; improvement of endothelial function, given their effects on prostaglandin synthesis and endothelial nitric oxide synthase; reduction of serum lipids, through their effects on the hepatic synthesis of triacylglycerides, beta-oxidation of fatty acids and lipoprotein catabolism; and improvement of myocardial function via their membrane-stabilizing effects, and an increase in fluidity, size and distribution of membrane lipid rafts. Nevertheless, these effects appear to vary according to the type of PUFA ingested, dietary sources, daily dosing and individual factors inherent to the subject. Therefore, further studies are required to determine the ideal supplementation for each kind of patient and their particular CV profiles. Key words:Cardiovascular disease, omega-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaeonic acid ABSTRACTArticle history:

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“…Ensaios clínicos demonstram os efeitos benéficos do ω3 em pacientes com doença cardiovascular, sendo que os mecanismos envolvidos estão relacionados ao seu papel anti-inflamatório 12 , ao efeito na redução plasmática dos triacilglicerois 13 , à redução da frequência cardíaca de repouso 14 , da pressão arterial 11 e da arritmia 15 e à melhora da capacidade funcional do miocárdio 16 . Recentemente, Din et al 17 demonstraram que o ω3 melhorou a fibrinólise e a função endotelial em indivíduos tabagistas, considerado um grupo de alto risco para eventos cardiovasculares.…”

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Impacto da suplementação com ácidos graxos ômega-3 nas subfrações da lipoproteína de alta densidade de indivíduos tabagistas

Pappiani

Damasceno

2016

Rev. Nutr.

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ObjetivoAvaliar o efeito da suplementação com ômega-3 nas subfrações das lipoproteínas de alta densidade em indivíduos tabagistas. MétodosEnsaio clínico, randomizado, duplo-cego. Foi selecionada uma amostra com 33 tabagistas, de ambos os sexos, com idade entre 30 e 60 anos, suplementados com ômega-3 (n=17) ou placebo (ácidos graxos ômega-6, n=16) por dois meses. As subfrações das lipoproteínas de alta densidade foram analisadas pelo sistema Lipoprint. Os testes estatísticos foram realizados com o auxílio do programa Statistical Package for the Social Sciences, versão 20.0. ResultadosA média de idade foi 49 anos, com predominância da raça branca. Após a intervenção, o grupo ômega-3 modificou positivamente o perfil lipídico e as subfrações das lipoproteínas de alta densidade dos tabagistas. Nos modelos de regressão linear testados, o percentual de ácido docosahexaenoico plasmático apresentou associações negativas com o percentual das lipoproteínas de alta densidade-pequena. ConclusãoA suplementação com ômega-3 está associada a uma alteração favorável na distribuição das subfrações das lipoproteínas de alta densidade, aumentando as lipoproteínas de alta densidade-grande e diminuindo as lipoproteínas de alta densidade-pequena. Isso reforça a importância do ômega-3 na saúde cardiovascular de indivíduos tabagistas. Palavras

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Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models

Cited by 125 publications

References 25 publications

Fish Intake and Risk of Incident Atrial Fibrillation

Fish Intake and Risk of Incident Atrial Fibrillation

Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function

Impacto da suplementação com ácidos graxos ômega-3 nas subfrações da lipoproteína de alta densidade de indivíduos tabagistas

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