Dietary Lipid Predictors of Coronary Heart Disease in Men

Bm, Posner; Jl, Cobb; Aj, Belanger; Cupples, L. Adrienne; Rb, D'Agostino; Stokes, Joseph

doi:10.1001/archinte.1991.00400060105018

Cited by 138 publications

(12 citation statements)

References 45 publications

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“…In other cohort studies [226,227,228,229,230,231,232] (LOE IIb), this relation was not significant. A sufficient degree of correction for confounding factors took place only in a small number of the older studies.…”

Section: Quantity and Quality Of Dietary Fat And Fatty Acid Intake mentioning

confidence: 68%

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Wolfram

Bechthold²,

Boeing

et al. 2015

Ann Nutr Metab

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As nutrition-related chronic diseases have become more and more frequent, the importance of dietary prevention has also increased. Dietary fat plays a major role in human nutrition, and modification of fat and/or fatty acid intake could have a preventive potential. The aim of the guideline of the German Nutrition Society (DGE) was to systematically evaluate the evidence for the prevention of the widespread diseases obesity, type 2 diabetes mellitus, dyslipoproteinaemia, hypertension, metabolic syndrome, coronary heart disease (CHD), stroke, and cancer through the intake of fat or fatty acids. The main results can be summarized as follows: it was concluded with convincing evidence that a reduced intake of total and saturated fat as well as a larger intake of polyunsaturated fatty acids (PUFA) at the expense of saturated fatty acids (SFA) reduces the concentration of total and low-density lipoprotein cholesterol in plasma. Furthermore, there is convincing evidence that a high intake of trans fatty acids increases risk of dyslipoproteinaemia and that a high intake of long-chain polyunsaturated n-3 fatty acids reduces the triglyceride concentration in plasma. A high fat intake increases the risk of obesity with probable evidence when total energy intake is not controlled for (ad libitum diet). When energy intake is controlled for, there is probable evidence for no association between fat intake and risk of obesity. A larger intake of PUFA at the expense of SFA reduces risk of CHD with probable evidence. Furthermore, there is probable evidence that a high intake of long-chain polyunsaturated n-3 fatty acids reduces risk of hypertension and CHD. With probable evidence, a high trans fatty acid intake increases risk of CHD. The practical consequences for current dietary recommendations are described at the end of this article.

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Section: Quantity and Quality Of Dietary Fat And Fatty Acid Intake mentioning

confidence: 68%

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Wolfram

Bechthold²,

Boeing

et al. 2015

Ann Nutr Metab

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show abstract

“…Although a direct association between saturated fat intake and risk of coronary disease has been reported in several studies,26 27 28 29 those findings may have been confounded by fibre intake. No significant associations were found in several other prospective investigations,30 31 32 33 34 35 but, with the exception of the Western Electric study,31 these had limited power because of their small size30 33 34 35 or inadequate dietary assessment 32 33.…”

Section: Discussionmentioning

confidence: 95%

Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States

Ascherio

Rimm

Giovannucci

et al. 1996

BMJ

641

410

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These data do not support the strong association between intake of saturated fat and risk of coronary heart disease suggested by international comparisons. They are compatible, however, with the hypotheses that saturated fat and cholesterol intakes affect the risk of coronary heart disease as predicted by their effects on blood cholesterol concentration. They also support a specific preventive effect of linolenic acid intake.

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“…There was also a positive association between the incidence of CHD and the proportion of dietary energy from MUFAs in the younger (45-55 year), but not older (55-65 year) cohort from the Framingham Study (Posner et al, 1991).…”

Section: Unsaturated Fatty Acidsmentioning

confidence: 91%

“…Total fat consumption as a percentage of energy intake was significantly higher in CHD victims in the Honolulu Heart Study (McGee et al, 1984;Yano et al, 1978), the urban cohort of the Puerto Rico Heart Health Program (Garcia-Palmieri et al, 1980) and in the 45-55 year age group in the Framingham Study (Posner et al, 1991). A comparison of the highest with the lowest intake of total fat produced an RR of 1.04 (1.01-1.08) for 30-59 year olds in the Lipid Research Clinics Prevalence Follow-up Study (Esrey et al, 1996).…”

Section: Total Fatmentioning

confidence: 91%

Has the association between saturated fatty acids, serum cholesterol and coronary heart disease been over emphasized?

Parodi¹

2009

International Dairy Journal

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Dietary Lipid Predictors of Coronary Heart Disease in Men

Cited by 138 publications

References 45 publications

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States

Has the association between saturated fatty acids, serum cholesterol and coronary heart disease been over emphasized?

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