Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma

Hazlewood, L. C.; Wood, Lisa G.; Hansbro, Philip M.; Foster, Paul S.

doi:10.1016/j.jnutbio.2009.12.003

Cited by 50 publications

(36 citation statements)

References 42 publications

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“…As IL-4 is the major inducer for class-switching to IgE biosynthesis in B lymphocytes, the decrease in serum IgE in cocoa-fed rats should be associated with lower IL-4 production. It is noteworthy that although some authors reported low levels of IL-4 after flavonoid treatment [30,31] others did not find any difference [12]. On the other hand, previous studies with a similar cocoa diet in rats noted a decrease of IL-4 production in spleen [16,18] but not in MLN cells [18].…”

Section: Discussionmentioning

confidence: 86%

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF) -α and the interleukin (IL) -10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases. 3

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Section: Discussionmentioning

confidence: 86%

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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“…However, vitamin A has also been shown to enhance Th2 immune responses 17 . Carotenoids may promote balanced Th1/Th2 immune responses, and lycopene supplementation has been shown to reduce allergic airway inflammation 18 , decrease circulating IL-4/IL-5 18 , and increase IFN-γ expression 19 in murine models.…”

Section: Vitamins With Antioxidant Properties (A C and E) And Asthmamentioning

confidence: 99%

Diet and asthma: vitamins and methyl donors

Han

Blatter

Brehm

et al. 2013

The Lancet Respiratory Medicine

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SUMMARY Dietary changes may partly explain the high burden of asthma in industrialized nations. Experimental studies have motivated a significant number of observational studies of the relation between vitamins (A, C, D, and E) or nutrients acting as methyl donors (folate, vitamin B12, and choline) and asthma. Because observational studies are susceptible to several sources of bias, well-conducted randomized controlled trials (RCTs) remain the “gold standard” to determine whether a vitamin or nutrient has an effect on asthma. Evidence from observational studies and/or relatively few RCTs most strongly justify ongoing and future RCTs of: 1) vitamin D to prevent or treat asthma, 2) choline supplementation as adjuvant treatment for asthma, and 3) vitamin E to prevent the detrimental effects of air pollution in subjects with asthma. At this time, there is insufficient evidence to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma.

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“…In addition, it seems that the non-pro-vitamin A carotenoid lycopene is associated with protection against atopy development [111,130,161,162,163]. Lycopene is in general not supplemented in infant nutrition, and so levels of it in the serum of children being fed fortified food are almost absent in comparison to breast-fed children (fig.…”

Section: What Is New and What To Do?mentioning

confidence: 99%

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Rühl

2013

Int Arch Allergy Immunol

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Carotenoids are important derivatives of the human diet and occur in high concentrations in the human organism. Various carotenoids are also present in human breast milk and are transferred to breast-fed children. The alternative to breastfeeding is supplementation with an infant milk formula, but these formulas contain only a limited variety of carotenoids. Our question is: ‘What is the function of various carotenoids in human nutrition with a special emphasis on child development and the development of atopy?’ In this review, the mechanisms of action of the most important non-pro-vitamin A and pro-vitamin A carotenoids: α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, lycopene and retinoids are discussed. In summary, the combination of carotenoids, especially lycopene, seems to be of great importance, and exclusive usage of β-carotene in infant formula may yield in an increased atopy prevalence mediated in various target organs like the skin, lungs and immune competent cells. We conclude that the determination of novel bioactive metabolites of various carotenoids, at various stages in different organs during atopy development, might be the key to understanding the potential importance of carotenoids on atopy development.

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Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma

Cited by 50 publications

References 42 publications

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Diet and asthma: vitamins and methyl donors

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

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