Dietary manganese suppresses α1 adrenergic receptor-mediated vascular contraction

Cardiovascular Toxicities Upon Manganese Exposure

“…In contrast, the pD values were significantly greater in the MnD group than in MnA and MnS animals, respectively, again indicating that a restriction of dietary Mn could affect vascular sensitivity to the α-1 AR agonist. One of the important implications of this study is that these results establish a clear relationship between dietary Mn exposure and vascular smooth muscle's ability to respond to an α-1 AR agonist (32).…”

Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats☆

“…Rings were mounted on two triangular stainless-steel wire specimen holders as previously described [12,26,27] and transferred to 20-ml Radnoti tissue baths, filled with PSS and aerated with 95% O 2 /5% CO 2 (37°C, pH 7.4). Each ring was attached to a fixed glass hook in the tissue bath and through a weightless wire hook to a force transducer connected to a digital tissue force analyzer (Model 410, MicroMed) for the measurement of isometric force, and which were recorded by an integrator software program (DMSI-410 version 1.01, Micro-Med, Kentucky, USA).…”

“…All four rings from each animal were exposed to six cumulative concentrations of Phe (in threefold steps) over the range 10 −8 to 3×10 −6 M, as it has been described before [26,28]. A drug-tissue contact time of 6 min was allowed for each Phe concentration to achieve the maximum contraction.…”

Copper Deficiency a New Reason of Androgenetic Alopecia?

“…Experimental data suggests that Mn down-regulated steroidogenesis in Leydig cells [15]. Mn influences the receptor signaling pathways and contractile machinery of vascular smooth muscle cells [16]. The expression of Mn-COD was significantly increased by 17β-estrogen and testosterone in neutrophil granulocytes in healthy volunteers [17].…”