Dietary mercury intake and colorectal cancer risk: A case-control study

Kim, Hye-Jin; Lee, Jeonghee; Woo, Hae Dong; Kim, Dong Woo; Oh, Jae Hwan; Chang, Hee Jin; Sohn, Dae Kyung; Shin, Aesun; Kim, Jeongseon

doi:10.1016/j.clnu.2019.08.025

Cited by 27 publications

(18 citation statements)

References 45 publications

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“…Accompanied with the increasing epidemiological and experimental evidences, diets rich in flavonoids, most of which are originated from plants, are likely to be associated with the risk reduction of colorectal cancer ( Grosso et al, 2017 ; Kim et al, 2020 ). Proanthocyanidin, consisting with flavan-3-ol subunits, have low oral bioavailability.…”

Section: Discussionmentioning

confidence: 99%

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Sun

Wang

Gao

et al. 2022

Current Research in Food Science

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Section: Discussionmentioning

confidence: 99%

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Sun

Wang

Gao

et al. 2022

Current Research in Food Science

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“…In a Mendelian randomization study where four single nucleotide polymorphisms (RS2282679, RS10741657, RS12785878, and RS6013897) were associated with vitamin D, there was little evidence for a linear casual association between circulating vitamin D concentration and risk of various types of cancer [ 44 ]. Finally, recent studies have proven beyond a reasonable doubt that vitamin D obtained from food (fish, dairy, eggs, and mushrooms) can be metabolized and activated through a CYP11A1-driven non-canonical metabolite pathway, and its dysregulation promises new methods for vitamin D-based cancer therapies [ 7 , 43 ].…”

Section: Micronutrients In the Prevention Of Cancermentioning

confidence: 99%

“…One important and easily adaptable approach is meeting the recommended micronutrient requirement and applying nutrigenomics tools to make the above more efficient and personalized. The main micronutrients with identified cancer-prevention properties are vitamin A, vitamin C, vitamin D, vitamin B 9 (folate), selenium, zinc, and magnesium [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Research in this discipline has supported the annual decline in cancer incidence and mortality [ 3 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer

Fagbohun

Gillies

Murphy

et al. 2023

IJMS

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Cancer is an escalating global issue, with 19.3 million new cases and 9.9 million deaths in 2020. Therefore, effective approaches to prevent cancer are urgently required. Diet plays a significant role in determining cancer risk. Nutrients and food bioactives influence specific signaling pathways in the body. Recently, there have been significant advances in cancer prevention research through nutrigenomics or with the effects of dietary components on the genome. Google Scholar, PubMed, and Scopus databases were used to search for peer-reviewed articles between 2017 and 2023. Criteria used were vitamins, minerals, tumors, cancer, genes, inflammation, signaling pathways, and nutrigenomics. Among the total of 1857 articles available, the highest relevant 90 articles that specifically discussed signaling pathways and genes on cancer cell lines and human cancer patients were selected and reviewed. Food sources are rich in antioxidant micronutrients, which are effective in activating or regulating signaling pathways involved in pathogenesis and cancer therapy by activating enzymes such as mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and phosphatidylinositol 3-kinase (PI3K). The micronutrients are involved in the regulation of β-catenin (WNT/β-catenin) including mutations in Kras and epidermal growth factor receptor (EGFR) alongside inhibition of the NF-kB pathway. The most common mechanism of cancer prevention by these micronutrients is their antioxidative, anti-inflammation, and anti-apoptosis effects. This review discusses how nutrigenomics is essential and beneficial for developing cancer prevention and treatment approaches.

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“…As such, we cannot ignore the role of heavy metals in the occurrence and development of cancer. Mercury, a genotoxic metal, contributes to the pathogenesis of many cancers, including colorectal and brain tumors ( 36 , 37 ). However, the role of mercury in the pathogenesis of human PC has not been explained.…”

Section: Hinting On the Pathogenesis Of Pc By Msmentioning

confidence: 99%

Application of Mass Spectrometry in Pancreatic Cancer Translational Research

Luo

Chen

et al. 2021

Front. Oncol.

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Pancreatic cancer (PC) is one of the most common malignant tumors in the digestive tract worldwide, with increased morbidity and mortality. In recent years, with the development of surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, and the change of the medical thinking model, remarkable progress has been made in researching comprehensive diagnosis and treatment of PC. However, the present situation of diagnostic and treatment of PC is still unsatisfactory. There is an urgent need for academia to fully integrate the basic research and clinical data from PC to form a research model conducive to clinical translation and promote the proper treatment of PC. This paper summarized the translation progress of mass spectrometry (MS) in the pathogenesis, diagnosis, prognosis, and PC treatment to promote the basic research results of PC into clinical diagnosis and treatment.

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Dietary mercury intake and colorectal cancer risk: A case-control study

Cited by 27 publications

References 45 publications

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer

Application of Mass Spectrometry in Pancreatic Cancer Translational Research

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