Dietary mineral intake and lung cancer risk: the Rotterdam Study

Abstract

ObjectiveLimited data are available on the role of mineral intake in the development of lung cancer (LC). We investigated whether dietary calcium, copper, iron, magnesium, selenium and zinc intake were associated with LC risk.MethodsWe analyzed data from 5435 participants of the Rotterdam Study, a prospective population-based cohort study among subjects aged 55 years and older. At baseline (1990–1993), diet was measured by a validated food frequency questionnaire. LC events were diagnosed on the basis of pathology data and medical records. Hazard ratios (HRs) on LC for energy-adjusted mineral intake were calculated using Cox regression models while adjusting for potential confounders.ResultsDuring a follow-up period of 22 years, we identified 211 incident cases of LC. A higher zinc intake was associated with 42 % reduction in risk of LC (top tertile vs. first tertile: HR 0.58, 95 % CI 0.35; 0.94, P-for trend = 0.039). Similarly, high intake of iron was associated with reduced risk of LC (top tertile vs. first tertile: HR 0.58, 95 % CI 0.37; 0.92, P-for trend = 0.021). There was no association between dietary intake of calcium, copper, magnesium and selenium and LC risk.ConclusionsOur results suggest that dietary zinc and iron intake are associated with reduced risk of LC. No evidence was found for an association between calcium, copper, magnesium and selenium intake and LC risk.Electronic supplementary materialThe online version of this article (doi:10.1007/s00394-016-1210-4) contains supplementary material, which is available to authorized users.

Dietary Iron Source and Lung Cancer Risk: A Case-Control Study in Uruguayan Men

“…High heme iron intake showed the strongest association with LC(OR=3.73, 95% CI 2.49-5.58, P Trend <0.001). The risk increase for heme iron intake and LC is compatible with some studies [24,28,30] but differs from other reports [25][26][27]29]. Non-heme iron intake was found to be directly associated with LC (OR=2.08, 95% CI 1.45-2.97, P Trend <0.001) which is in agreement with the study of Zhou et al, [29] who also found an inverse association for heme iron intake and LC.…”

“…On one Table 3 Regarding animal/plant ratio, the putative risk categories correspond to those appearing in the quoted Table. The existing differences between Table and Figure hand, Ward et al, [30] reported a significant risk increase for heme iron in patients with small cell carcinomas. On the other hand, Muka et al, [26] found no risk differences regarding total iron intake and subtypes of LC. In fact, all subtypes tended to be associated in a protective sense.…”

“…These studies reported epidemiologic evidence of an animal/plant ratio [22] as well as a heme/non-heme ratio [23] of dietary iron in support of a direct association to the disease. Besides, only a few epidemiologic studies (all of them conducted in North American and European populations) have been published on the role of heme iron in LC risk [24][25][26][27][28][29][30]. Most of them tended to display a risk elevation by increasing heme iron intake.…”

Mikronährstoffe in der Onkologie: Risiko und Nutzen – Update 2020

“…Die 2017 publizierte Rotterdam-Studie mit 5435 Teilnehmern zeigte keinen Einfluss von Selen (Befragung hinsichtlich der Ernährung) auf das Lungenkrebsrisiko [88].…”

Mild Cognitive Impairment and Dementia Show Contrasting Associations with Risk of Cancer

“…To minimize the potential impact of preexisting subclinical malignancy on cognition (i.e., reverse causation), we repeated analyses after excluding the first 2 and 5 years of follow-up. This was performed in sample 1 by excluding the first 2 and 5 years following study entry for persons free of dementia, and the first 2 and 5 years after dementia diagnosis for dementia patients [16, 17]. In sample 2, the first 2 and 5 years after baseline were excluded for both persons with and without MCI.…”