Dietary mold oil rich in gamma linolenic acid increases insulin-dependent glucose utilization in isolated rat adipocytes

Ishii, Takashi; Kushiro, Masayo; Takahashi, Yōko

doi:10.1016/s1096-4959(01)00462-6

Cited by 6 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Ide et al (2001), dietary g-linolenic acid increased glucose metabolism in isolated rat adipocytes. Substituting dietary linoleic acid with a-linolenic acid resulted in lowered blood lipid level and improved insulin sensitivity in sucrose fed rats (Ghafoorunissa et al, 2005).…”

Section: Treatmentsmentioning

confidence: 99%

Effects ofGrifola frondosanon-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice

Shen

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Ng (2015) Effects of Grifolafrondosa non-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice, Pharmaceutical Biology, 53:5, 705-709, DOI: 10.3109/13880209.2014 In vitro hypoglycemic effects of GF was evaluated enzymatically using a-amylase and a-glucosidase inhibition assays, whereas in vivo study was conducted on high-fat diet fed and streptozotocin (HFD + STZ)-induced hyperglycemic mice. GC-MS was used to determine the chemical profiles of bioactive components.Results: The non-polar fraction of GF exhibited a stronger anti-a-glucosidase activity (IC 50 : 0.0332 mg/ml) than acarbose, but its anti-a-amylase activity (IC 50 : 0.671 mg/ml) was weaker. Oral administration of GF at 600 mg/kg (GF600) significantly lowered the blood glucose, HbA1c, average blood glucose, and serum total cholesterol levels in hyperglycemic mice. Although GF was found to contain mainly oleic acid and linoleic acid, their levels in the fungus were low, suggesting that the effects of GF on HFD + STZ-induced hyperglycemic mice could be due to factors other than these fatty acids. Conclusion: These results conclude that GF possesses anti-a-glucosidase activity, and hypoglycemic effect in HFD + STZ-induced hyperglycemic mice.

show abstract

Section: Treatmentsmentioning

confidence: 99%

Effects ofGrifola frondosanon-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice

Shen

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…Polyunsaturated fatty acids were shown to attenuate oxidative stress and prevent chemically induced DM in experimental animals . In vitro studies showed that oils rich in eicosapentaenoic acid, docosahexaenoic acid, γ‐linolenic acid, and arachidonic acid prevented alloxan‐induced cytotoxicity in RIN cells , and increased glucose metabolism in isolated rat adipocytes . Oleic acid effectively decreased low density lipoprotein (LDL) cholesterol level and protected LDL particles from oxidation in vivo , as well as reducing adipocyte expression and resistin secretion, which are involved in the reduction of obesity‐induced insulin resistance and Type 2 DM .…”

Section: Introductionmentioning

confidence: 99%

Inhibitory potential of fatty acids on key enzymes related to type 2 diabetes

Hsu

2013

BioFactors

View full text Add to dashboard Cite

This study aimed to examine the inhibitory mechanisms of fatty acids on key enzymes related to type 2 diabetes, and their effects on starch digestion rate. Among the 10 fatty acids analyzed, oleic acid showed the strongest anti-α-glucosidase activity, followed by linoleic acid, and their activities were more potent than acarbose, but they possessed a weaker anti-α-amylase activity. Kinetic assays demonstrated that oleic acid and linoleic acid were competitive inhibitors, and their interactions with α-glucosidase exhibited a character of static quenching, which indicates that they would bind to α-glucosidase to form a complex. However, they had little effects on the secondary structures of α-glucosidase. In vitro study showed that oleic acid and linoleic acid were more potent than acarbose in inhibiting starch digestion. Taken together, these results conclude that oleic acid and linoleic acid possess potent inhibitory effects on α-glucosidase activity.

show abstract

“…Regarding the physiological effects of oils rich in GLA on glucose metabolism, a recent study found that dietary borage oil rich in GLA ameliorates insulin resistance in a diet-induced obesity model of Wistar rats 58) . In relation to this, we previously demonstrated that dietary mold oil rich in GLA increases insulin-dependent glucose utilization (oxidation and conversion to fatty acids) in isolated rat adipocytes 59) . Information regarding the physiological effects of GLA on serum glucose levels in mice is lacking.…”

Section: Effects Of Dietary Fats On Serum and Liver Lipids Andmentioning

confidence: 85%

γ-Linolenic Acid-Rich Oil- and Fish Oil-Induced Alterations of Hepatic Lipogenesis, Fatty Acid Oxidation, and Adipose Tissue mRNA Expression in Obese KK-A y Mice

Ishii

2023

J. Oleo Sci.

Self Cite

View full text Add to dashboard Cite

IntroductionPrevious studies 1−3) have demonstrated that dietary fats rich in γ-linolenic acid (GLA) increased hepatic fatty acid oxidation in rats. These effects were marked for peroxisomal fatty acid oxidation. However, the increase in activity observed in these studies was moderate (20-80％) . We recently provided evidence that dietary GLA more markedly increases hepatic fatty acid oxidation in mice. In this study, the effect elicited by evening primrose oil rich in GLA (42.6％, GLA oil) was compared with that of palm oil (a saturated fat) and safflower oil (an oil rich in linoleic acid but devoid of GLA) . We found that GLA-rich oil strongly and dose-dependently increased hepatic fatty acid oxidation in a hyperlipidemic mouse strain lacking apolipoprotein E (apoE) expression (BALB/c.KOR/StmSlc Apoe shl ) 4) .

show abstract

Dietary mold oil rich in gamma linolenic acid increases insulin-dependent glucose utilization in isolated rat adipocytes

Cited by 6 publications

References 27 publications

Effects ofGrifola frondosanon-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice

Effects ofGrifola frondosanon-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice

Inhibitory potential of fatty acids on key enzymes related to type 2 diabetes

γ-Linolenic Acid-Rich Oil- and Fish Oil-Induced Alterations of Hepatic Lipogenesis, Fatty Acid Oxidation, and Adipose Tissue mRNA Expression in Obese KK-<i>A</i> <sup> <i>y</i> </sup> Mice

Contact Info

Product

Resources

About