Effects ofGrifola frondosanon-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice

Shen, Kuo‐Ping; Su, Chun-Han; Lu, Tzy-Ming; Lai, Min-Nan; Ng, Lean‐Teik

doi:10.3109/13880209.2014.939290

Cited by 19 publications

(12 citation statements)

References 27 publications

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“…The CD36 mRNA expression in hepatocytes is normally low, but an important increase is observed by a high-fat diet or by the activation of nuclear receptors including peroxisome proliferator-activated receptor (PPAR)- [39]. We can registered a modulatory effect of AERM in liver PPAR-γ mRNA expression associated to an important inhibition of CD36 mRNA expression ( Figure 6A), suggesting that AERM induces the down regulation of our work for effective activity of AERM (50 mg/kg), as well as, acarbose in vivo is only effective at 40 mg/kg/day [47,48], suggesting that an anti-lipase and anti-amylase activity could be important in the lipid lowering, glucose homeostasis and hepatoprotective effects of AERM. Interestingly, mice treated with AERM did not present reduced adiposity but pro-inflammatory gene expression was reduced when compared with obese non-treated ( Figure 6B), suggesting that AERM have anti-inflammatory activity mitigating obesity associated adipose tissue inflammation that could contribute to reverse the insulin resistance.…”

Section: In Vivo Activities Of the Aermmentioning

confidence: 75%

Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Mesquita¹,

Caria²,

Santos³

et al. 2018

Preprint

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Rhizophora mangle L. is a well-known medicinal plant found in mangroves worldwide used to treatment diabetes. This study evaluated the chemical composition of the acetonic extract from Rhizophora mangle barks (AERM), by HPLC-PDA and FIA-ESI-IT-MS/MS and the effects on high-fat diet induced obesity in mice and its mechanism of action by gene expression of inflammatory markers (Pparg, Ppara, Srebf1, Cd36, Tnf, Ccl2, Lep, Il10, Il6, Fasn, 18s). High-fat diet fed mice during 12 weeks was used as model of obesity and associated alterations. The results were very satisfactory, the extract, rich in polyphenolic compounds, flavonoids and phenolic acids, displayed intense antioxidant activity in vitro (608 µmol Trolox/g), and showed excellent activity against non-alcoholic fatty liver disease (NAFLD) and reverse insulin resistance in a model of diet-induced obesity. We can registered a modulatory effect of AERM in liver PPAR-γ mRNA expression associated to an important inhibition of CD36 mRNA expression suggesting that AERM induces the down regulation of CD36 mRNA via PPAR-gamma inhibition. These results support the traditional knowledge about the use of R. mangle for the treatment of type 2 diabetes and reveal the potential of AERM for the treatment of NAFLD and management of obesity and comorbidities.

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Section: In Vivo Activities Of the Aermmentioning

confidence: 75%

Modulatory Effect of Polyphenolic Compounds from the Mangrove tree Rhizophora mangle L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Mesquita¹,

Caria²,

Santos³

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…In vivo administration of orlistat requires doses around 50 mg/kg to determine lowering serum triglycerides (TG) effects and probably it explain why we did not observe it in vivo with AERM. However, in vivo, acarbose is only effective at 40 mg/kg/day [ 50 , 51 ], suggesting that anti-amylase activity could be a role for glucose homeostasis and for the hepatoprotective effects of AERM.…”

Section: Resultsmentioning

confidence: 99%

Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

et al. 2018

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No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge.

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“…Glucose uptake was enhanced in a dose-dependent manner and the insulin receptor protein in the cell membrane was activated. In another study using high-fat diet fed and streptozotocin-induced hyperglycaemic mice, a non-polar fraction of Grifola frondosa significantly lowered blood glucose level, serum total cholesterol, and showed a strong anti-α-glucosidase activity, an enzyme that acts on the breakdown of starch and disaccharides [124]. Recently, a water extract of a mushroom used in traditional Chinese medicine (Ganoderma lucidum) was demonstrated to reduce body weight, inflammation and insulin resistance; the obesity induced gut dysbiosis (ratio of Bateroidetes to Firmicutes) was reversed in mice, and a high molecular weight polysaccharide (>300 kDa) isolated from this extract was stated as the possible responsible compounds for the anti-obesity and microbiota-modulating effect [125].…”

Section: From Fungimentioning

confidence: 98%

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

Castro¹,

Preto²,

Vasconcelos³

et al. 2016

CTMC

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Obesity is a global health threat. OECD reported that more than half (52%) of the adult population in the European Union is overweight or obese. Obesity and obesity-related co-morbidities have deep negative effects on morbidity, mortality, professional and personal quality of life. Healthcare costs represent a negative impact of this disease, with an associated economic cost of 100 billion US$ per year in the United States. The most prescribed drugs for obesity treatment worldwide are orlistat, and phentermine/topiramate extended release, while the major prescribed drug for the same disease in the US are exenatide and dapagliflozin. The so far developed drugs, targeting weight loss, have a long history of malignant secondary effects. There is still a lack of efficient and safe drugs to treat obesity and related metabolic complications since in many cases cure cannot be reached by bariatric surgery or healthy lifestyle habits. Terrestrial and aquatic organisms are a promising source of valuable, bioactive compounds, often with interest for human health. Some of the natural compounds or organisms have been used for centuries by humans as traditional medicine foods. In this review, we give insights into the adipose tissue function and development, and the progress in traditional anti-obesity pharmacotherapy. A major focus is to highlight the state of the art of natural compounds with anti-obesity properties and their potential as candidates for drug development; an overview is given about natural compounds derived from different marine animal sources, cyanobacteria, marine phytoplankton, fungus or plants.

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Effects ofGrifola frondosanon-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice

Cited by 19 publications

References 27 publications

Modulatory Effect of Polyphenolic Compounds from the Mangrove tree <em>Rhizophora mangle </em>L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Modulatory Effect of Polyphenolic Compounds from the Mangrove tree <em>Rhizophora mangle </em>L. Improving Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

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