Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice

Tanaka, Nobuyuki; Kono, Hiroshi; Ishii, Kenichi; Hosomura, Naohiro; Fujii, Hideki

doi:10.1007/s00535-009-0088-9

Cited by 14 publications

(14 citation statements)

References 38 publications

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“…This result agrees with that of Wu et al [42] and Tanaka et al [43] who reported decreased food intake due to toxicity with CCl 4 . Moreover, decrease in food intake was detected after administration of olive oil and Nigella sativa to rats received CCl 4 .…”

Section: Discussionsupporting

confidence: 93%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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BackgroundLiver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to compare the probable hepatoprotective activity of olive oil and N. sativa oil on CCl4 induced liver damage in male rats.MethodsForty males of a new model of albino rats (Wistar strain) (175–205 g) were divided into four groups. The 1st Group (G1) was the negative control group, the remaining rats were injected with CCl4 (1 ml/kg body weight) with equal amount of olive oil on the 1st and 4th day of every week for 4 weeks. The 2nd group (G2) was the positive control, the 3rd group (G3) and the fourth group (G4) were treated orally with N. sativa oil and olive oils using stomach tube.ResultsThe positive control group showed an increase in hepatic enzymes, total bilirubin, creatinine, uric acid, lipid peroxide total cholesterol, triglyceride, low density lipoprotein, very low density lipoproteins, interleukin-6, and a decrease in antioxidant enzymes, high density lipoprotein cholesterol, a decrease in total protein and albumin an when compared with negative control group. Histology of the CCl4 treated group revealed inflammation and damage of liver cells. Treating the hepatotoxic rats with olive oil and N. sativa oil showed a significant improvement in all biochemical tests compared with the positive CCl4 control group. In addition, the liver tissues of olive oil treated group showed mild improvement in inflammatory infiltration and in N. sativa oil treated group showed normal hepatocytes with no evidence of inflammation.ConclusionThis study revealed that olive oil and N. sativa oil have a protective effect against CCl4-induced hepatotoxicity in male rats. Nigella sativa oil was more effective than olive oil.

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Section: Discussionsupporting

confidence: 93%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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“…In line, retinoid or retinoic acid have been shown to attenuate liver fibrogenesis in cultured HSC and in vivo in CCl 4 ‐induced liver injury through the inhibitory effects of collagen type I production and reduced liver injury from oxidative stress (34, 35). In addition, recent reports confirm that oleic acid reduce the severity of CCl 4 ‐induced liver fibrosis (36, 37). LCN2, therefore, might be relevant in fibrogenesis with regard to retinol transport, reception and storage in HSC.…”

Section: Resultsmentioning

confidence: 91%

Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation

Borkham-Kamphorst¹,

Drews²,

Weiskirchen³

2011

Liver International

119

112

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“…Indeed, while oleic acid can be synthesized de novo through the activity of the Stearoyl-CoA desaturase 1 (SCD1), it is clear from results obtained in germline Scd1 KO mice [4–7], liver-specific Scd1 KO mice [8;9] and in mice overexpressing Scd3 [10] that oleate can contribute to various physiological functions, notably in liver. Dietary olive oil [11] and oleic acid [12] have been shown to have beneficial effects in different experimental models of hepatic pathologies termed Non Alcoholic Fatty Liver Diseases (NAFLD) that range from steatosis to steatohepatitis (NASH). Despite its promoting effect on hepatic lipid accumulation, oleic acid synthesized de novo also contributes to protect hepatocytes from insulin resistance [13].…”

Section: Introductionmentioning

confidence: 99%

Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling

et al. 2017

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Olive oil consumption is beneficial for health as it is associated with a decreased prevalence of cancer and cardiovascular diseases. Oleic acid is, by far, the most abundant component of olive oil. Since it can be made through de novo synthesis in animals, it is not an essential fatty acid. While it has become clear that dietary oleic acid regulates many biological processes, the signaling pathway involved in these regulations remains poorly defined. In this work we tested the impact of an oleic acid-rich diet on hepatic gene expression. We were particularly interested in addressing the contribution of Liver X Receptors (LXR) in the control of genes involved in hepatic lipogenesis, an essential process in whole body energy homeostasis. We used wild-type mice and transgenic mice deficient for both α and β Liver X Receptor isoforms (LXR-/-) fed a control or an oleate enriched diet. We observed that hepatic-lipid accumulation was enhanced as well as the expression of lipogenic genes in the liver of wild-type mice fed the oleate enriched diet. In contrast, none of these changes occurred in the liver of LXR-/- mice. Strikingly, oleate-rich diet reduced cholesterolemia in wild-type mice and induced signs of liver inflammation and damage in LXR-/- mice but not in wild-type mice. This work suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.

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Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice

Abstract: Dietary olive oil prevents CCl(4)-induced tissue injury and fibrosis in the liver. Since oleic acid inhibited activation of HSCs, oleic acid may play a key role on this mechanism.

Cited by 14 publications

References 38 publications

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation

Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling

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