Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance of<i>Pseudomonas aeruginosa</i>Lung Infection in Mice by Modulating Intestinal Microbiota and Immunity

Bernard, H.; Desseyn, Jean‐Luc; Bartke, Nana; Kleinjans, Lennart; Stahl, Bernd; Belzer, Clara; Knol, Jan; Gottrand, Frédéric; Husson, Marie-Odile

doi:10.1093/infdis/jiu391

Cited by 49 publications

(36 citation statements)

References 46 publications

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“…Stimulating the growth of species involved in immunity development, such as Bifidobacterium species, Sutturella wadsworthia, and Clostridium cluster XIVa organisms, and at the same time increased the production of butyrate and propionate seems to be possible to restore Th1 bias and INF-γ levels that improves bacterial clearance [86].…”

Section: Mycobacterium Abscessus Infectionsmentioning

confidence: 99%

“…In addition, alterations of the intestinal microbiota impacts the systemic immune response, reports suggest that dietary acidic oligosaccharides can favor a Th1 immune response, restoring INF-α level in the lung and bacterial clearance [86].…”

Section: Treatments Of Cf Diseasementioning

confidence: 99%

“…Active components like zingerone (extracted from ginger) could increase the P. aeruginosa sensitivity to antibiotics by reducing its cell surface hydrophobicity and decreasing the alginate and LPS production. Consequently, there is an increase in its susceptibility to phagocytosis by macrophages decreasing the TNF-α and MIP-2 levels [86]. Other works reveal that extracts of garlic could act as anti-quorum sensing molecules, preventing biofilm formation, increasing the clearing of the infecting bacteria and potentiating the effect of tobramycin [101].…”

Section: Nano Particles Therapiesmentioning

confidence: 99%

“…Studies in mice models indicate that pretreatment with pectinderived acidic oligosaccharides may help to improve the incidence of P. aeruginosa pulmonary infection by increasing bacterial clearance with a shift in the Th1/Th2 balance toward a predominantly Th1 response [86].…”

Section: Patients With Cf Have Reduced Intestinal Richness With Low Lmentioning

confidence: 99%

“…A complementary strategy is based on the ingestion of prebiotics has a positive impact in the restoration of a health microbiota at intestine and an enhancement of the systemic immune response is usually observed. Reports suggest that dietary acidic oligosaccharides can favor a Th1 immune response, restoring INF-α level in the lung and bacterial clearance [86].…”

Section: Dietary Supplementsmentioning

confidence: 99%

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Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Grumelli¹,

Islan²,

Castro³

2016

Pulm Crit Care Med

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Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date.

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Section: Mycobacterium Abscessus Infectionsmentioning

confidence: 99%

Section: Treatments Of Cf Diseasementioning

confidence: 99%

Section: Nano Particles Therapiesmentioning

confidence: 99%

Section: Patients With Cf Have Reduced Intestinal Richness With Low Lmentioning

confidence: 99%

Section: Dietary Supplementsmentioning

confidence: 99%

See 3 more Smart Citations

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Grumelli¹,

Islan²,

Castro³

2016

Pulm Crit Care Med

View full text Add to dashboard Cite

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Regulatory Roles of Pectin Oligosaccharides on Immunoglobulin Production in Healthy Mice Mediated by Gut Microbiota

Zhang

et al. 2019

Molecular Nutrition Food Res

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Scope: The prebiotic regulation of the gut microbiota is a promising strategy to induce protective humoral and mucosal immune responses. The potential immune-improving effects of pectin oligosaccharides (POS) in healthy mice and the potential mechanism mediated by specific intestinal bacteria are investigated. Methods and results: POS is prepared using a hydrogen-peroxide-assisted degradation. Mice that consumed diets containing POS are tested for microbial community shifts, short-chain fatty acids (SCFAs), and immunoglobulin (Ig) production using quantitative real-time polymerase chain reaction, gas chromatography, and ELISA kits. Pearson's correlation analyses are performed between Ig production and specific intestinal bacteria or SCFAs. POS treatment significantly improves the growth of healthy mice. Moreover, 4-week POS administration results in a profound change in intestinal microbial composition and a significantly higher fecal concentration of acetate, which leads to substantial increases of the levels of fecal secretory immunoglobulin A and serum IgG. Conclusions: The results suggest that the inclusion of POS in a diet can increase Ig production and optimize the composition of the gut microbiota. A significant correlation is observed between changes in Ig production and specific intestinal bacteria or acetate, providing insight into the mechanism of POS as a potential immune-enhancing supplement. Keywords gut microbiota, pectin oligosaccharides, secretory immunoglobulin A, serum IgG, short-chain fatty acids

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Crosstalk Between Lung and Extrapulmonary Organs in Infection and Inflammation

Wang

Huang³

et al. 2021

Advances in Experimental Medicine and Biology

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Acute and chronic lung inflammation is a risk factor for various diseases involving lungs and extrapulmonary organs. Intercellular and interorgan networks, including crosstalk between lung and brain, intestine, heart, liver, and kidney, coordinate host immunity against infection, protect tissue, and maintain homeostasis. However, this interaction may be counterproductive and cause acute or chronic comorbidities due to dysregulated inflammation in the lung. In this chapter, we review the relationship of the lung with other key organs during normal cell processes and disease development. We focus on how pneumonia may lead to a systemic pathophysiological response to acute lung injury and chronic lung disease through organ interactions, which can facilitate the development of undesirable and even deleterious extrapulmonary sequelae.

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Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance ofPseudomonas aeruginosaLung Infection in Mice by Modulating Intestinal Microbiota and Immunity

Abstract: These results suggest that pAOS may have beneficial effects by limiting the number and severity of pulmonary exacerbations in patients chronically infected with P. aeruginosa, such as individuals with cystic fibrosis.

Cited by 49 publications

References 46 publications

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Regulatory Roles of Pectin Oligosaccharides on Immunoglobulin Production in Healthy Mice Mediated by Gut Microbiota

Crosstalk Between Lung and Extrapulmonary Organs in Infection and Inflammation

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