Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice

“…Corn oil (COR), rich in linoleic acid but poor in ALNA (<2%), was purchased from Chang Chi Foodstuff Factory Co. (Taichung, Taiwan, ROC) as a control and the source of n‐6 fatty acid. The fatty acid composition in COR consists of 49.3% linoleic acid, 28.5% oleic acid, 2.1% stearic acid, and 12.9% palmitic acid 14, 15. Compound oil (COR‐PER) was a mixture containing 50% COR and 50% PER.…”

Section: Methodsmentioning

confidence: 99%

“…The allergic asthmatic inflammation murine model has been used in our previous studies 14–16. The mice (8‐wk‐old) were sensitized and challenged to induce allergic airway inflammation.…”

Section: Methodsmentioning

confidence: 99%

“…It was found that PER plays different physiological roles, including the inhibition of the growth of Staphylococcus aureus and the production of exotoxins in vitro 11, the inhibition of monocyte recruitment to inflamed intestinal mucosa in the senescence accelerated mice (SAM)P1/Yit mouse model 12, as well as the protection of mitochondrial function in the brain in guinea pigs 13. In our previous studies, dietary PER also demonstrated many physiological effects including hypolipidemia and immunomodulation in vivo via decreasing the secretion levels of pro‐inflammatory cytokines (TNF‐α, IL‐1β, and IL‐6) and Th1 cytokines (IFN‐γ and IL‐2) in bronchoalveolar lavage fluid (BALF) of ovalbumin (OVA)‐sensitized and challenged mice, suggesting that dietary PER alleviated inflammation via decreasing the secretion of pro‐inflammatory cytokines in BALF 14, 15. However, chronic asthma may cause both local and systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of dietary perilla oil on allergic inflammation in asthmatic mice

Chang

Chen

Lin

2012

Euro J Lipid Sci & Tech

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Perilla oil (PER) is rich in α‐linolenic acid (n‐3 fatty acid). To unravel the effects of dietary PER on allergic asthmatic inflammation, three kinds of dietary oil, including PER, corn oil (COR), and perilla compound oil (50% PER and 50% COR), were used for replacing the oil in an AIN76 feed consumed by ovalbumin (OVA)‐sensitized and challenged mice continuously for 5 wk. T‐helper type 1 lymphocyte (Th1)/T‐helper type 2 lymphocyte (Th2) and pro‐/anti‐inflammatory cytokines secreted by the cells from the airway, the lungs, and the spleen of experimental mice were determined by ELISA. The results showed that dietary PER inhibited interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α secretions by lipopolysaccharide (LPS)‐stimulated lung cells, as well as interferon (IFN)‐γ and IL‐6 secretions by LPS‐stimulated splenocytes. Perilla compound oil increased the secretion ratio of IFN‐γ/IL‐5 (Th1/Th2 cytokines) in LPS‐stimulated bronchoalveolar lavage fluid cells, but decreased the ratio of IL‐6/IL‐10 (pro‐/anti‐inflammatory cytokines) in LPS‐stimulated splenocytes. The present study demonstrated that dietary PER and its compound oil protected the airways, the lungs, and the spleen from allergic inflammation in OVA‐challenged asthmatic mice, suggesting that an appropriate n‐6/n‐3 fatty acid ratio at a ratio of 1:1 or less in dietary oil may be beneficial to improve the Th2‐skewed allergic asthmatic inflammation. Practical applications: The present study demonstrated that dietary PER and its compound oil protected the airways, the lungs, and the spleen from allergic inflammation in OVA‐challenged asthmatic mice, suggesting that an appropriate n‐6/n‐3 fatty acid ratio at a ratio of 1:1 or less in dietary oil may be beneficial to improve the Th2‐skewed allergic asthmatic inflammation.

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“…Perilla oil (PO) from roasted P. frutescens seeds has been reported to possess biological activities against atherosclerosis (Sadi and others 1996), chemically induced cancers (Onogi and others 1996), and asthma in vitro and in vivo (Deng and others 2007). Also, the levels of serum lipids and ovalbumin‐specific IgG1 decreased in ovalbumin‐challenged mice fed with PO (Chang and others 2009). …”

Section: Introductionmentioning

confidence: 99%

Effects of Roasting Conditions on the Physicochemical Properties and Volatile Distribution in Perilla Oils (Perilla frutescens var. japonica)

Park

Seol²,

Chang³

et al. 2011

Journal of Food Science

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Perilla oil (PO) from perilla seeds possesses more than 60% of α-linolenic acid, one of omega-3 fatty acids. Roasting process has been used to extract oil from perilla seeds. Understanding physicochemical properties of PO from diverse roasting conditions are important steps to produce PO in food industry. Roasting process induces darkening of color, increase of fluorescence intensity, and brown pigments in PO. Pyrazines and furans are major headspace volatiles in PO roasted above 170°C. The results of this study can help to produce PO in industrial scales with desired headspace volatiles, colors, and oxidative state.

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Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice

Cited by 41 publications

References 42 publications

The impact of transgenic papaya (TPY10-4) fruit supplementation on immune responses in ovalbumin-sensitised mice

The impact of transgenic papaya (TPY10-4) fruit supplementation on immune responses in ovalbumin-sensitised mice

Protective effect of dietary perilla oil on allergic inflammation in asthmatic mice

Effects of Roasting Conditions on the Physicochemical Properties and Volatile Distribution in Perilla Oils (Perilla frutescens var. japonica)

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