Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study

Abstract

This study aimed to test the association between dietary content of total and individual classes of polyphenols and incident cases of type 2 diabetes in Polish adults participating to the Health, Alcohol and Psychosocial factors In Eastern Europe study. At baseline, diet by 148-item FFQ and health information were collected from 5806 participants free of diabetes. Self-reported incident type 2 diabetes was ascertained at 2–4-year follow-up visit. OR and 95 % CI of type 2 diabetes comparing the various categories of polyphenol intake to the lowest one (reference category) and as 1 sd increase modelled as continuous variable were calculated by performing age-, energy-, and multivariate-adjusted logistic regression models. During the follow-up, 456 incident cases of type 2 diabetes occurred. When comparing extreme quartiles, intake of total polyphenol was inversely associated with the risk of type 2 diabetes (OR 0·43; 95 % CI 0·30, 0·61); 1 sd increase was associated with a reduced risk of diabetes (OR 0·68; 95 % CI 0·59, 0·79). Among the main classes of polyphenols, flavonoids, phenolic acids, and stilbenes were independent contributors to this association. Both subclasses of phenolic acids were associated with decreased risk of type 2 diabetes, whereas among subclasses of flavonoids, high intake of flavanols, flavanones, flavones and anthocyanins was significantly associated with decreased risk of type 2 diabetes. Total dietary polyphenols and some classes of dietary polyphenols were associated with lower risk of type 2 diabetes.

Efektifitas Pemberian Buah Apel Manalagi Dengan Dosis Bervariasi Terhadap Penurunan Kadar Glukosa Darah Pada Penderita Diabetes Mellitus Tipe Ii Di Kelompok Prolanis Puskesmas Genuk Kota Semarang

“…Buah apel memiliki berbagai macam varietas antara lain apel Anna, Romebauty, Manalagi dan lainnya.Buah apel manalagi memiliki rasa yang lebih manis dibandingkan varietas yang lain. 5,23,24,25 Apel mengandung pektin kimia berserat alami yang mampu mengurangi kadar glukosa darah hingga 50%.Hasil studi yang telah dilakukan di salah satu Universitas di Jepang, menunjukkan bahwa kadar glukosa darah turun secara signifikan pada penderita diabetes mellitus dalam waktu 24 jam setelah makan apel dosis 2 x 100 gram. Selain itu, gejala komplikasi diabetes mellitus juga berkurang secara signifikan dengan mengkonsumsi buah apel.…”

Higher phenolic acid intake independently associates with lower prevalence of insulin resistance and non-alcoholic fatty liver disease

“…19 Hydroxycinnamic acids include cinnamic, p-coumaric, ferulic, rosmarinic, caffeic and chlorogenic acid. 20 There is epidemiological evidence that phenolic acid intake is inversely associated with occurrence of diabetes, 21 hypertension 22,23 and the metabolic syndrome. 24 Furthermore, preclinical data in experimental models have shown that even a single phenolic acid may exert protective effects against NAFLD.…”

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“…They are the most abundant antioxidants in the diet of human beings 40 . Dietary polyphenol is associated with lower rates of diabetes and cardiovascular disease 41,42 . Phenolic compounds have strong in-vitro and in-vivo antioxidant activities associated with their ability to scavenge free radicals, break radical chain reactions and chelate metals ions 43 .…”