Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

Borsoi, Felipe Tecchio; Neri-Numa, Iramaia Angélica; Oliveira, Williara Queiroz de; Araújo, Fábio Fernandes de; Pastore, Gláucia Maria

doi:10.1016/j.fochms.2022.100155

Cited by 24 publications

(12 citation statements)

References 133 publications

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“…According to previous studies, EGCG forges hydrogen bonds between the residues in the active site of the enzyme; thus, it directly inhibits DNMTs and suppresses DNA methylation indirectly by increasing homocysteine levels and S‐adenosyl‐L‐homocysteine (SAH) while lowering SAM 75 . Furthermore, EGCG also affects histone modifications by preventing HMTs 76 . Green tea catechins have been reported to have anti‐obesity properties.…”

Section: Obesity and Epigenetic Therapy With Natural Productsmentioning

confidence: 99%

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Chen,

Wang,

Chen

et al. 2024

Pharmacology Res & Perspec

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Obesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary modifications. In light of the tremendous disease burden and unmet therapeutics, fresh perspectives on pathophysiology and drug discovery are needed. The development of epigenetics provides a compelling justification for how environmental, lifestyle, and other risk factors contribute to the pathogenesis of obesity. Furthermore, epigenetic dysregulations can be restored, and it has been reported that certain natural products obtained from plants, such as tea polyphenols, ellagic acid, urolithins, curcumin, genistein, isothiocyanates, and citrus isoflavonoids, were shown to inhibit weight gain. These substances have great antioxidant potential and are of great interest because they can also modify epigenetic mechanisms. Therefore, understanding epigenetic modifications to target the primary cause of obesity and the epigenetic mechanisms of anti‐obesity effects with certain phytochemicals can prove rational strategies to prevent the disease and develop novel therapeutic interventions. Thus, the current review aimed to summarize the epigenetic mechanisms and advances in therapies for obesity based on natural products to provide evidence for the development of several potential anti‐obesity drug targets.

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Section: Obesity and Epigenetic Therapy With Natural Productsmentioning

confidence: 99%

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Chen,

Wang,

Chen

et al. 2024

Pharmacology Res & Perspec

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show abstract

“…This class of bioactive compounds shows a large diversity of structures, including rather simple molecules (phenolic acids) and polyphenols such as stilbenes, flavonoids, lignans, and tannins, that can be found free or associated with carbohydrates, lipids, cell wall components, amines, and organic acids [ 34 ]. Phenolic compounds have multiple biochemical actions as antioxidant agents, and they are involved in the modulation of signaling pathways, gene expression, and the modification of epigenetic changes mainly related to chronic non-communicable diseases (e.g., metabolic syndromes, cancers, and neurodegenerative diseases) [ 35 ]. Therefore, phenolic compounds can be alternative or complementary tools for the prevention or management of non-communicable chronic diseases.…”

Section: Bioactive Compounds Found In Araticum Fruit Partsmentioning

confidence: 99%

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Arruda

Borsoi

Andrade

et al. 2023

Plants

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Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, and economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the scientific advances achieved so far and identifying gaps to be filled is essential to direct future studies and transform accumulated knowledge into innovative technologies and products. In this review, we summarize the phytochemical composition, bioactivities, and food products from araticum fruit that have been reported in the scientific literature over the past 10 years. The compiled data showed that araticum fruit parts contain a wide range of bioactive compounds, particularly phenolic compounds, alkaloids, annonaceous acetogenins, carotenoids, phytosterols, and tocols. These phytochemicals contribute to different biological activities verified in araticum fruit extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing of the cutaneous wound, antibacterial, and insecticide effects. Despite the promising findings, further studies—particularly toxicological (especially, with byproducts), pre-clinical, and clinical trials—must be conducted to confirm these biological effects in humans and assure the safety and well-being of consumers.

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“…In physiological conditions, the production of radicals is minimal and is counteracted by endogenous cellular mechanisms. However, exogenous or endogenous factors can increase oxidative stress and impair the activity of cellular oxidoreductive processes ( Borsoi et al, 2023 ). This disruption in the balance between radical production and endogenous mechanisms may contribute to the development and progression of various diseases including cancer.…”

Section: Resultsmentioning

confidence: 99%

Pressurized liquid extraction of glucosinolates from Camelina sativa (L.) Crantz by-products: Process optimization and biological activities of green extract

Pagliari,

Domínguez‐Rodríguez,

Cifuentes

et al. 2024

Food Chemistry: X

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Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

Cited by 24 publications

References 133 publications

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Pressurized liquid extraction of glucosinolates from Camelina sativa (L.) Crantz by-products: Process optimization and biological activities of green extract

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