Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Chen, Peng; Wang, Yulai; Chen, Fuchao; Zhou, Benhong

doi:10.1002/prp2.1171

Cited by 2 publications

(1 citation statement)

References 152 publications

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“…A clinical trial of genistein alone has been reported to have a beneficial effect on postmenopausal females with metabolic syndrome [230]. Relevant to the present discussion are also reports that flavonoids, including genistein, can exert epigenetic effects [231][232][233][234][235]. Therefore, several aspects of these diets and natural products are very compatible with the proposed epigenetic-based mechanism for post-menopausal conditions.…”

Section: Conclusion and The Way Forwardsupporting

confidence: 59%

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

Hart

2024

IJMS

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For much of human evolution, the average lifespan was <40 years, due in part to disease, infant mortality, predators, food insecurity, and, for females, complications of childbirth. Thus, for much of evolution, many females did not reach the age of menopause (45–50 years of age) and it is mainly in the past several hundred years that the lifespan has been extended to >75 years, primarily due to public health advances, medical interventions, antibiotics, and nutrition. Therefore, the underlying biological mechanisms responsible for disease risk following menopause must have evolved during the complex processes leading to Homo sapiens to serve functions in the pre-menopausal state. Furthermore, as a primary function for the survival of the species is effective reproduction, it is likely that most of the advantages of having such post-menopausal risks relate to reproduction and the ability to address environmental stresses. This opinion/perspective will be discussed in the context of how such post-menopausal risks could enhance reproduction, with improved survival of offspring, and perhaps why such risks are preserved. Not all post-menopausal females exhibit risk for this set of diseases, and those who do develop such diseases do not have all of the conditions. The diseases of the post-menopausal state do not operate as a unified complex, but as independent variables, with the potential for some overlap. The how and why there would be such heterogeneity if the risk factors serve essential functions during the reproductive years is also discussed and the concept of sets of reversible epigenetic changes associated with puberty, pregnancy, and lactation is offered to explain the observations regarding the distribution of post-menopausal conditions and their potential roles in reproduction. While the involvement of an epigenetic system with a dynamic “modification-demodification-remodification” paradigm contributing to disease risk is a hypothesis at this point, validation of it could lead to a better understanding of post-menopausal disease risk in the context of reproduction with commonalities may also lead to future improved interventions to control such risk after menopause.

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Section: Conclusion and The Way Forwardsupporting

confidence: 59%

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

Hart

2024

IJMS

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Research progress on the influence of traditional Chinese medicine on tumor microenvironment therapy

Gao,

Cao,

Ning

et al. 2024

New Updates in Tumor Microenvironment [Working Title]

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More and more attention has been paid to the tumor microenvironment. The occurrence, development, metastasis, and drug resistance of tumor are closely related to the tumor microenvironment. At the same time, the application of traditional Chinese medicine (TCM) in tumor prevention and treatment has attracted more and more attention due to its regulatory effect on tumor cells and tumor microenvironment. The holistic view and multitarget regulatory view of TCM make it very suitable for the regulation of tumor microenvironment. This article will review the current research status of the molecular mechanism of TCM regulation of tumor microenvironment from three aspects: TCM can reverse the inhibitory phenotype of immune cells, TCM can enhance the immune response to tumor cells, and TCM clinical application.

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Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Cited by 2 publications

References 152 publications

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

Research progress on the influence of traditional Chinese medicine on tumor microenvironment therapy

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