Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Li, Yueqin; Peng, Yao; Shen, Yingbin; Zhang, Yunzhen; Liu, Lianliang; Yang, Xinquan

doi:10.1080/10408398.2022.2076064

Cited by 79 publications

(65 citation statements)

References 262 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-sugar diets are generally considered to be an unhealthy lifestyle [107]. Abundant clinical studies have confirmed that a high-sugar diet can lead to an OS state in the body, which accelerates the development of multisystem pathologies, such as diabetes, neurodegenerative and cardiovascular diseases [108][109][110]. A high-sugar diet, whether long-term, short-term or fluctuating, can affect the body's redox status and thus have a negative impact on ovarian function [111].…”

Section: High-sugar Dietmentioning

confidence: 99%

The role of oxidative stress in ovarian aging: a review

et al. 2022

View full text Add to dashboard Cite

Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is considered to be a key factor. This review focuses on the fact that OS status accelerates the ovarian aging process by promoting apoptosis, inflammation, mitochondrial damage, telomere shortening and biomacromolecular damage. Current evidence suggests that aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents and industrial pollutants can be factors that accelerate ovarian aging by exacerbating OS status. In addition, we review the role of nuclear factor E2-related factor 2 (Nrf2), Sirtuin (Sirt), mitogen-activated protein kinase (MAPK), protein kinase B (AKT), Forkhead box O (FoxO) and Klotho signaling pathways during the process of ovarian aging. We also explore the role of antioxidant therapies such as melatonin, vitamins, stem cell therapies, antioxidant monomers and Traditional Chinese Medicine (TCM), and investigate the roles of these supplements with respect to the reduction of OS and the improvement of ovarian function. This review provides a rationale for antioxidant therapy to improve ovarian aging.

show abstract

Section: High-sugar Dietmentioning

confidence: 99%

The role of oxidative stress in ovarian aging: a review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The role of gut hormones and gut–brain communication in the regulation of food intake has become a hot topic in recent years. The bidirectional interaction between the gut and central nervous system (CNS) plays a pivotal role in a wide range of physiological control mechanisms, including appetite, energy homeostasis, and glucose homeostasis [ 20 , 21 , 22 ]. The potential of these peripheral signals to provide novel targets for developing anti-obesity medications is particularly intriguing.…”

Section: Introductionmentioning

confidence: 99%

Hormonal Gut–Brain Signaling for the Treatment of Obesity

Roh

Choi

2023

IJMS

View full text Add to dashboard Cite

The brain, particularly the hypothalamus and brainstem, monitors and integrates circulating metabolic signals, including gut hormones. Gut–brain communication is also mediated by the vagus nerve, which transmits various gut-derived signals. Recent advances in our understanding of molecular gut–brain communication promote the development of next-generation anti-obesity medications that can safely achieve substantial and lasting weight loss comparable to metabolic surgery. Herein, we comprehensively review the current knowledge about the central regulation of energy homeostasis, gut hormones involved in the regulation of food intake, and clinical data on how these hormones have been applied to the development of anti-obesity drugs. Insight into and understanding of the gut–brain axis may provide new therapeutic perspectives for the treatment of obesity and diabetes.

show abstract

“…Advanced glycation end-products (AGEs) are a heterogeneous group of compounds derived from spontaneous non-enzymatic glycation (or Maillard reaction) between reducing sugars and proteins, nucleic acids or lipids [ 1 ]. AGEs have been shown to cross-link with intracellular or extracellular proteins altering their physiological properties and functions [ 2 ], accumulate in cells or tissues contributing to chronic diseases, diabetic complications, cardiovascular diseases and are also involved in the progression of neurodegenerative diseases [ 3 ] such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) [ 4 , 5 ], and during the physiological aging process or in autoimmune disease [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Hazelnut Skin Food Waste and Protective Role against Advanced Glycation End-Products (AGEs) Damage in THP-1-Derived Macrophages

et al. 2023

View full text Add to dashboard Cite

Glycation and the accumulation of advanced glycation end-products (AGEs) are known to occur during aging, diabetes and neurodegenerative diseases. Increased glucose or methylglyoxal (MGO) levels in the blood of diabetic patients result in increased AGEs. A diet rich in bioactive food compounds, like polyphenols, has a protective effect. The aim of this work is to evaluate the capacity of hazelnut skin polyphenolic extract to protect THP-1-macrophages from damage induced by AGEs. The main polyphenolic subclass was identified and quantified by means of HPLC/MS and the Folin–Ciocalteu method. AGEs derived from incubation of bovine serum albumin (BSA) and MGO were characterized by fluorescence. Cell viability measurement was performed to evaluate the cytotoxic effect of the polyphenolic extract in macrophages. Reactive oxygen species’ (ROS) production was assessed by the H2-DCF-DA assay, the inflammatory response by real-time PCR for gene expression, and the ELISA assay for protein quantification. We have shown that the polyphenolic extract protected cell viability from damage induced by AGEs. After treatment with AGEs, macrophages expressed high levels of pro-inflammatory cytokines and ROS, whereas in co-treatment with polyphenol extract there was a reduction in either case. Our study suggests that hazelnut skin polyphenol-rich extracts have positive effects and could be further investigated for nutraceutical applications.

show abstract

Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Cited by 79 publications

References 262 publications

The role of oxidative stress in ovarian aging: a review

The role of oxidative stress in ovarian aging: a review

Hormonal Gut–Brain Signaling for the Treatment of Obesity

Chemical Composition of Hazelnut Skin Food Waste and Protective Role against Advanced Glycation End-Products (AGEs) Damage in THP-1-Derived Macrophages

Contact Info

Product

Resources

About