2009
DOI: 10.1161/strokeaha.109.555383
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Dietary Protein, but Not Carbohydrate, Is a Primary Determinant of the Onset of Stroke in Stroke-Prone Spontaneously Hypertensive Rats

Abstract: Background and Purpose-Previously, an inverse association has been found between the dietary proportion of protein or fat and incidence of intracerebral hemorrhage. A positive association has been found with respect to carbohydrate intake. To examine what changes in macronutrient intake are causative, animal studies were conducted. Methods-Stroke-prone spontaneously hypertensive rats (SHRSP) were fed diets with varying ratios of macronutrients ad libitum, and the onset of stroke was examined. Results-When 10% … Show more

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Cited by 16 publications
(8 citation statements)
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“…Brains were removed, and CVECs were harvested as described previously [16]. CVECs were cultured with Endothelial Cell Basal Medium-2 (Lonza, Walkersville, MD, USA) and used within 10 passage numbers.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Brains were removed, and CVECs were harvested as described previously [16]. CVECs were cultured with Endothelial Cell Basal Medium-2 (Lonza, Walkersville, MD, USA) and used within 10 passage numbers.…”
Section: Methodsmentioning
confidence: 99%
“…Onset of stroke was assessed by the appearance of neurologic symptoms and physiological changes as described previously [16]. …”
Section: Methodsmentioning
confidence: 99%
“…Perhaps it is low total protein intake, reflecting diets in which white rice predominates, that is the true culprit; Asian epidemiologists should devote further attention to this issue. In stroke-prone spontaneously hypertensive rats, thought to be a good model for lacunar stroke and hemorrhage associated with SVD, high dietary protein intakes postpone stroke and mortality [ 128 , 129 ]. Total protein has been linked to decreased stroke risk in some but not all prospective epidemiology; animal protein in particular emerges as protective in Asian epidemiology, as well as dietary correlates such as saturated fat and increased LDL cholesterol [ 130 , 131 , 132 , 133 , 134 , 135 ].…”
Section: The Impact Of Dietary Proteinmentioning
confidence: 99%
“…The onset of stroke was assessed according to the appearance of neurological symptoms (hyperkinetic/ hypokinetic behaviors, hyper/hyposensitivity [manipulation], proleg lift or piloerection) and physiological changes (a decrease in body weight or food intake or increase in drinking water intake) as previously described 14) . Two researchers checked for these symptoms at 10:00 am every day.…”
Section: Stroke Onsetmentioning
confidence: 99%