Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats

Chiba, Tsuyoshi; Yokotani, Kaori; Suzuki, Sachina; Itoh, Tatsuki; Umegaki, Keizo

doi:10.5551/jat.27789

Cited by 2 publications

(4 citation statements)

References 39 publications

(47 reference statements)

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“…After removing duplicate and not relevant records, 90 full-text articles and one congress abstract were assessed for eligibility. Reasoned exclusions (16 studies) 18 –33 rendered 75 studies included in the qualitative synthesis, 34 …”

Section: Resultsmentioning

confidence: 99%

“…After removing duplicate and not relevant records, 90 full-text articles and one congress abstract were assessed for eligibility. Reasoned exclusions (16 studies) [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] rendered 75 studies included in the qualitative synthesis, and further exclusions (18 studies) 36,43,44,46,56,61,64,65,69,76,78,83,92,93,98,103,104,107 resulted in 57 studies subjected to meta-analysis of seven stroke outcomes. 34,35,37-42,45,47-55,57-60,62,63,66-68, 70-75,77,79-82,84-91,94-97,99-102,105,106,108…”

Section: Literature Searchmentioning

confidence: 99%

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Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis

López-Morales,

Castelló-Ruiz,

Burguete

et al. 2023

J Cereb Blood Flow Metab

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Resveratrol (RSV) holds promise as cerebroprotective treatment in cerebral ischemia. This systematic review aims to assess the effects and mechanisms of RSV in animal models of ischemic stroke. We searched Medline, Embase and Web of Science to identify 75 and 57 eligible rodent studies for qualitative and quantitative syntheses, respectively. Range of evidence met 10 of 13 STAIR criteria. Median (Q1, Q3) quality score was 7 (5, 8) on the CAMARADES 15-item checklist. Bayesian meta-analysis showed SMD estimates (95% CI) favoring RSV: infarct size (−1.72 [−2.03; −1.41]), edema size (−1.61 [−2.24; −0.98]), BBB impairment (−1.85 [−2.54; −1.19]), neurofunctional impairment (−1.60 [−1.92; −1.29]), and motor performance (1.39 [0.64; 2.08]); and less probably neuronal survival (0.63 [−1.40; 2.48]) and apoptosis (−0.96 [−2.87; 1.02]). Species (rat vs mouse) was associated to a larger benefit. Sensitivity analyses confirmed robustness of the estimates. Reduction of oxidative stress, inflammation, and apoptosis underlie these effects. Our results quantitatively state the beneficial effects of RSV on structural and functional outcomes in rodent stroke models, update the evidence on the mechanisms of action, and provide an exhaustive list of targeted signaling pathways. Current evidence highlights the need for conducting further high-quality preclinical research to better inform clinical research.

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Section: Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis

López-Morales,

Castelló-Ruiz,

Burguete

et al. 2023

J Cereb Blood Flow Metab

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“…92 In addition, 0.0% resveratrol exerts a marginally inhibitory effect on serum IL-1b and monocyte chemotactic protein 1 levels, which are involved in inflammation in SHRSP. 93 In addition, experiments using aorta specimens isolated from SHRs showed that resveratrol induced calciumdependent endothelial NO synthase phosphorylation, thereby enhancing NO production and inducing vascular relaxation. 94 Furthermore, resveratrol (25-100 mM) prevented the proliferation of vascular smooth muscle cells isolated from SHRs.…”

Section: Effects Of Resveratrolmentioning

confidence: 99%

“…92 In addition, 0.0% resveratrol exerts a marginally inhibitory effect on serum IL-1β and monocyte chemotactic protein 1 levels, which are involved in inflammation in SHRSP. 93…”

Section: Introductionmentioning

confidence: 99%

Altered Properties of Neurons and Astrocytes and the Effects of Food Components in Stroke-Prone Spontaneously Hypertensive Rats

Yamagata

Yamori

2021

Journal of Cardiovascular Pharmacology

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:In stroke-prone spontaneously hypertensive rats (SHRSP), stroke induces neuronal vulnerability and neuronal death, while astrocytes show a weakened support function toward neurons. Moreover, certain food components have been demonstrated to prevent the occurrence of stroke. This review aims to explain the stroke-related properties of SHRSP-derived neurons and astrocytes. In addition, it describes the effects of particular dietary phytochemicals on SHRSP. In this study, we obtained information using PubMed, ScienceDirect, and Web of Science. We searched for the functions of neurons and astrocytes and the molecular mechanism of ischemic stroke induction. We summarized the recent literature on the underlying mechanisms of stroke onset in SHRSP and the alleviating effects of typical food-derived phytochemical components. Neuronal death in SHRSP is induced by hypoxia-reoxygenation, suggesting the involvement of oxidative stress. Furthermore, the production of lactate, l-serine, and glial cell line-derived neurotrophic factor in SHRSP-derived astrocytes was reduced compared with that in control Wistar–Kyoto rats. Vitamin E exerts an inhibitory effect on hypoxia-reoxygenation–induced neuronal death in SHRSP. Curcumin, epigallocatechin gallate, resveratrol, and carotenoids can prevent the development of stroke in SHRSP. In particular, the properties of SHRSP-derived neurons and astrocytes affect stroke-induced neuronal death. This review suggests the potential and therapeutic applications of dietary phytochemicals in reducing stroke risk and lowering blood pressure in SHRSP, respectively, by targeting various processes, including oxidative stress, apoptosis, and inflammation. Thus, future research on SHRSP brain cells with a genetic predisposition to stroke can consider using these food ingredients to develop approaches for stroke prevention.

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Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats

Cited by 2 publications

References 39 publications

Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis

Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis

Altered Properties of Neurons and Astrocytes and the Effects of Food Components in Stroke-Prone Spontaneously Hypertensive Rats

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