Dietary Protein Intake and Single-Nephron Glomerular Filtration Rate

Oba, Rina; Kanzaki, Go; Sasaki, Takaya; Okabayashi, Yusuke; Haruhara, Kotaro; Koike, Kentaro; Kobayashi, Adam; Yamamoto, Izumi; Tsuboi, Nobuyuki; Yokoo, Takashi

doi:10.3390/nu12092549

Cited by 18 publications

(16 citation statements)

References 43 publications

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“…The study found proteinuria to be one of the two strongest predictors in the rate of CKD progression in two studies [ 23 ]. Oba et al collected 43 healthy (non-diseased) kidneys from live human donors to examine the effect of an HPD on the single-nephron GFR (SNGFR) [ 24 ]. This study concluded that an HPD might increase SNGFR and induce glomerular hyperfiltration; however, this study is unique by identifying that the analysis of human SNGFR is an exemplary parameter to alterations in renal hemodynamics at the single-nephron level [ 24 ].…”

Section: Medical Nutrition Therapymentioning

confidence: 99%

Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Naber

Purohit

2021

Nutrients

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Chronic kidney disease affects ≈37 million adults in the US, and it is often undiagnosed due to a lack of apparent symptoms in early stages. Chronic kidney disease (CKD) interferes with the body’s physiological and biological mechanisms, such as fluid electrolyte and pH balance, blood pressure regulation, excretion of toxins and waste, vitamin D metabolism, and hormonal regulation. Many CKD patients are at risk of hyperkalemia, hyperphosphatemia, chronic metabolic acidosis, bone deterioration, blood pressure abnormalities, and edema. These risks may be minimized, and the disease’s progression may be slowed through careful monitoring of protein, phosphorus, potassium, sodium, and calcium, relieving symptoms experienced by CKD patients. In this review, the current Kidney Disease Outcomes Quality Initiative (KDOQI) recommendations are highlighted, reflecting the 2020 update, including explanations for the pathophysiology behind the recommendations. The Dietary Approaches to Stop Hypertension, the Mediterranean diet, and the whole foods plant-based diet are currently being examined for their potential role in delaying CKD progression. Biological explanations for why the whole foods plant-based diet may benefit CKD patients compared to diets that include animal products are examined. Strong evidence continues to support the importance of diet meeting the daily requirement in the prevention and progression of kidney disease, and medical nutrition therapy with a registered dietitian is a critical aspect in medical intervention for CKD.

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Section: Medical Nutrition Therapymentioning

confidence: 99%

Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Naber

Purohit

2021

Nutrients

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“…HPDs contribute to progressive glomerular damage, which, combined with the renal deterioration from diseased kidneys, may contribute to a more rapid disease progression in renal patients. Oba et al collected 43 healthy (non-diseased) kidneys from live human donors to examine the effect of a HPD on the single-nephron GFR (SNGFR) [55]. This study concluded that a HPD might increase SNGFR and induce glomerular hyperfiltration; however, this study is unique by identifying that the analysis of human SNGFR is an exemplary parameter to alterations in renal hemodynamics at the single-nephron level [55].…”

Section: Protein and Renal Functionmentioning

confidence: 93%

“…Glomerular hyperfiltration is defined as modifying renal hemodynamics through glomerular capillary hyperemia and increasing intraglomerular pressure [53]. HPD induce glomerular hyperfiltration; hyperemia and increased hydraulic pressure result in vasodilation of the afferent arteriole [55]. HPDs contribute to progressive glomerular damage, which, combined with the renal deterioration from diseased kidneys, may contribute to a more rapid disease progression in renal patients.…”

Section: Protein and Renal Functionmentioning

confidence: 99%

“…Oba et al collected 43 healthy (non-diseased) kidneys from live human donors to examine the effect of a HPD on the single-nephron GFR (SNGFR) [55]. This study concluded that a HPD might increase SNGFR and induce glomerular hyperfiltration; however, this study is unique by identifying that the analysis of human SNGFR is an exemplary parameter to alterations in renal hemodynamics at the single-nephron level [55]. The exact mechanism for renal hemodynamic responses to heightened protein intake is not yet understood [56].…”

Section: Protein and Renal Functionmentioning

confidence: 99%

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Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Naber¹,

Purohit²

2021

Preprint

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Chronic kidney disease is a critical health crisis in the US, affecting about 37 million adults. Known as "the silent killer" because it is often undiagnosed until it has reached a stage of progression. Renal dysfunction causes many adverse effects to the body's biological mechanisms, such as fluid electrolyte and pH balance, blood pressure regulation, excretion of toxins and waste, vitamin D metabolism, and hormonal regulation. Many CKD patients experience hyperkalemia, hyperphosphatemia, chronic metabolic acidosis, bone deterioration, blood pressure abnormalities, and edema. Symptoms experienced may be minimized, and the disease's progression may be slowed through an appropriate diet, which is why medical nutrition therapy is a critical aspect of the medical intervention for CKD. The current KDOQI recommendations are proposed as well as the physiological mechanisms behind the recommendations. Current biological explanations of the effects of a whole foods plant-based diet are included for possible contrast with the current renal diet. Strong evidence continues to support the importance of proper nutrition in the prevention and progression of kidney disease.

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“…Floriano and coworkers used bioelectrical impedance analysis, hand grip strength tests and five repetitions of sit-to-stand tests in a cohort of 113 kidney transplant recipients and showed that uric acid (UA) levels were positively associated with muscle mass and strength, but not with functional capacity [ 11 ], while Dominguez-Zabrano et al underlined the antioxidant properties of uric acid in HD patients [ 12 ]. In another interesting study involving living kidney donors, Oba and coworkers showed that single nephron Glomerular Filtration Rate (GFR) was directly associated with protein intake but not with sodium intake, BMI or arterial pressure [ 13 ].…”

mentioning

confidence: 99%