Dietary pyridoxine interaction with tryptophan or histidine on brain serotonin and histamine metabolism

Lee, Nam Soo; Muhs, Georgia; Wagner, George C.; Reynolds, Robert D.; Fisher, Hans

doi:10.1016/0091-3057(88)90020-2

Cited by 21 publications

(9 citation statements)

References 26 publications

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“…A further explanation to the effect of vitamin B-6 on insulin response to a glucose load might be linked to its role in decarboxylation of tryptophan to serotonin. Indeed, in rats, it has been shown that B-6 supplements can stimulate serotonin synthesis in the brain (Hartvig et al 1995), although the effects would be more marked after concommitant supplements of B-6 and tryptophan (Lee et al 1988). Additional studies are needed to investigate the importance of this metabolic pathway because of the role of this amine on insulin secretion and sensitivity (Furman and Waton 1989).…”

Section: Response To Duodenal Infusion Of Glucose or Glucose + Tryptomentioning

confidence: 99%

Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets

Matte¹,

Ponter²,

Sève³

1997

Can. J. Anim. Sci.

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Matte, J. J., Ponter, A. A. and Sève, B. 1997. Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets. Can J. Anim. Sci. 77: 663-668. In order to investigate the importance of the relation between pyridoxine and tryptophan on glucose tolerance and insulin response to glucose, 12 Large White × Pietrain piglets (males and females), weaned at 3 wk of age, were allocated to two treatment groups. Within each of the six pairs (four females and two males), one piglet received daily 3 mL i.m. of pyridoxine.HCl (5 g L -1 ) and the other received a control injection of saline. The animals were fed a liquid feed through a gastric tube surgically inserted on the day of weaning. Seven days later, one catheter was placed in the duodenum and another in the jugular vein. One week after recovery, the piglets received an intraduodenal infusion of glucose or glucose + tryptophan; 2 d later, each piglet received the opposite treatment. There was no effect (P > 0.18) of the administration of pyridoxine.HCl on plasma pyridoxal and pyridoxal-5-phosphate. Whatever the pyridoxine treatment, the plasma glucose response was lower (P ≤ 0.05) after the glucose + tryptophan infusion than after the glucose infusion. There was, also, an interaction between parenteral pyridoxine and duodenal infusion on changes in plasma insulin concentrations following the duodenal infusion (P ≤ 0.02). The greatest response, observed in piglets supplemented with pyridoxine.HCl and infused with glucose, was 55% higher than for the three other treatments. Further work is needed for an eventual reliable estimate of the pyridoxine status and requirements of weanling piglets. The tryptophan and pyridoxine effects on insulin metabolism suggest a different action of these nutrients on sensitivity and release of insulin.Key words: Pyridoxine, tryptophan, glucose, insulin, weanling piglets Matte, J. J., Ponter, A. A. et Sève, B. 1997. Effets de l'administration parentérale chronique de pyridoxine et de l'infusion entérique aigüe de tryptophane sur le statut en pyridoxine, la glycémie et l'insulinémie stimulées par le glucose chez le porcelet sevré. Can J. Anim. Sci. 77: 663-668. Dans le but de déterminer l'importance de la pyridoxine et du tryptophane sur le statut en pyridoxine, la glycémie et l'insulinémie stimulée par le glucose, douze porcelets Large White × Pietrain (mâles et femelles) ont été sevrés à l'âge de 3 semaines et ont été distribués dans deux groupes expérimentaux. À l'intérieur de chacune des 6 paires formées, (4 femelles et 2 mâles), un porcelet a reçu une injection i. m. journalière de 3 mL de pyridoxine.HCl (5 g L -1 ) alors que l'autre a reçu une injection de saline. Les animaux recevaient une alimentation liquide administrée par un tube de gavage installé lors du sevrage. Sept jours plus tard, un cathéter a été installé dans le duodénum et un autre dans la veine jugulaire. Une semaine plus tard, les porcelets ont reçu une infusion intrad...

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Section: Response To Duodenal Infusion Of Glucose or Glucose + Tryptomentioning

confidence: 99%

Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets

Matte¹,

Ponter²,

Sève³

1997

Can. J. Anim. Sci.

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“…A by-product of the histidine-histamine studies was the observation that a high intake of pyridoxine and of histidine stimulated the activity of the enzyme histidine decarboxylase and increased histamine production (27). We then found that, analogously, on a high-pyridoxine and an elevated tryptophan intake, the activity of 5-hydroxytryptophan decarboxylase and the serotonin level in rat brain were significantly elevated (27).…”

Section: Studies On Ethanolmentioning

confidence: 83%

“…We then found that, analogously, on a high-pyridoxine and an elevated tryptophan intake, the activity of 5-hydroxytryptophan decarboxylase and the serotonin level in rat brain were significantly elevated (27). In collaboration with Dr. Wagner, a neuropsychologist from the Rutgers Psychology Department, we carried out a multifaceted series of studies that involved alcohol metabolism, much of it related to serotonin and its precursor amino acid, tryptophan.…”

Section: Studies On Ethanolmentioning

confidence: 99%

From Tryptophan to Hydroxytryptophan: Reflections on a Busy Life

Fisher

2009

Annu. Rev. Nutr.

Self Cite

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Given the very difficult odyssey of my early years, who could have imagined the incredible and successful journey that constituted my life path after age 13? I was born into a Jewish family in Breslau, Germany, right before the rise of Nazism and Hitler's election. After Kristallnacht, when my father was taken to Buchenwald Concentration Camp, we had to leave Germany as soon as possible. The first opportunity came in May of 1939, when we boarded the SS St. Louis bound for Havana, Cuba. Almost all passengers were denied entrance into Cuba, and the ship had to go back to Europe, where I ended up in France. In December of 1939, during World War II, I was fortunate to be able to leave France. This time I made it to Cuba, where my father was already in residence. A year later, my entire family was allowed into the United States. I took advantage of all the educational resources in this land of opportunity. I graduated valedictorian of my high school class and earned a four-year scholarship to Rutgers University, where I obtained a Bachelor of Science degree. I went on to earn a Master's degree from the University of Connecticut and finally a PhD from the University of Illinois. Within two months after graduating from Illinois, I was hired as an assistant professor of nutritional biochemistry at Rutgers, where I enjoyed a most productive research and teaching career. My PhD research involved tryptophan and niacin metabolism in the chick, and upon arrival at Rutgers I continued amino acid studies with the goal of assessing the essential amino acid requirements for egg production. This research was crowned with success and was followed with amino acid requirement studies for maintenance and for growth in rabbits, and ultimately with a reevaluation of requirements in adult humans. An outgrowth of the maintenance requirements led to a series of investigations into the metabolism of histidine, histamine, and carnosine (a histidine-containing dipeptide). Histamine, we found, plays an important role in wound healing and stress management. Pyridoxal phosphate is the cofactor for the enzyme histidine decarboxylase required for histamine synthesis and similarly serves as a cofactor for hydroxytryptophan decarboxylase, the enzyme that is part of the pathway to serotonin synthesis. Investigations into these pathways led to interesting findings: brain concentrations of serotonin could be increased by supplementing the diet of rats with tryptophan and pyridoxine; the elevated brain serotonin levels had behavioral consequences. Alcohol craving, addiction, and withdrawal symptoms are affected by serotonin concentrations in the brain, and alleviation of these conditions can be achieved with simultaneous administration of serotonin and dopamine agonists. In the midst of our early amino acid studies, we serendipitously also became involved with lipid metabolism in relation to atherosclerosis and blood cholesterol in a chicken model. This work led to the recognition that soluble fibers, like pectin, had strong cholesterol-lowering properties that were beneficial in lowering the incidence of coronary plaque formation. The research success that I have enjoyed has been coupled with the gift of three accomplished children who are making important contributions as professionals in their fields of endeavor. My wife and I are also blessed with 10 wonderful grandchildren, our pride and joy!

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“…In the present experiment, vitamin B 6 was added to Trp in order to enhance its effect. Indeed, in rats, it has been shown that vitamin B 6 supplements can stimulate serotonin synthesis in the brain (Hartvig et al 1995), especially following concomitant supplementation with vitamin B 6 and tryptophan (Lee et al 1988). In pigs, a modulation of dietary tryptophan has been shown on brain serotonin (Meunier-Salau¨n et al 1991).…”

Section: Behaviourmentioning

confidence: 99%

“…Vitamin B 6 (pyridoxine), which plays a key role in the metabolism of Trp in pigs (Matte et al 2001), could be also involved. In rats, B 6 supplements can stimulate serotonin synthesis in the brain (Hartvig et al 1995), especially following concomitant supplementation with B 6 and tryptophan (Lee et al 1988).…”

mentioning

confidence: 99%

Effects of water supplementation with tryptophan and vitamin B₆ or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs

et al. 2012

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R. 2012. Effects of water supplementation with tryptophan and vitamin B 6 or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs. Can. J. Anim. Sci. 92: 319Á326. A current food safety challenge at pig slaughter plants comes with the presence of stomachs filled with liquid induced by hunger-related drinking in lairage. With the objective to reduce hunger-related excess drinking, 30 barrows were assigned to three treatments (10 pigs per treatment): (1) unsupplemented water or feed regimen (CONT), (2) L-Tryptophan (3 g L(1 ) and vitamin B 6 (10 mg L(1 ) in the drinking water for 5d (TRP-B6), (3) hydrogenated fat (HF) supplemented at 10% in the diet for the last day of feeding before pre-slaughter fasting. As compared with CONT, neither TRP-B6 nor HF supplementation influenced behaviour in lairage and water intake at anytime over the pre-slaughter fasting period as reflected on stomach weight and its liquid content at slaughter (P0.10). However, in HF-fed pigs plasma non-esterified fatty acids concentrations tended to be lower (P00.09) while carcass yield was higher (P00.04) than CONT pigs. It appears, therefore, that neither drinking water supplementation with TRP-B6 for 5 d nor feeding HF the last day before slaughter can be recommended strategies to limit excess water drinking prior to slaughter and liquid stomach content at slaughter. However, dietary HF supplementation the last day before slaughter may attenuate the effects of fasting on body energy reserves and improve carcass yield.

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Dietary pyridoxine interaction with tryptophan or histidine on brain serotonin and histamine metabolism

Cited by 21 publications

References 26 publications

Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets

Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets

From Tryptophan to Hydroxytryptophan: Reflections on a Busy Life

Effects of water supplementation with tryptophan and vitamin B₆ or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs

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Dietary pyridoxine interaction with tryptophan or histidine on brain serotonin and histamine metabolism

Cited by 21 publications

References 26 publications

Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets

Effects of chronic parenteral pyridoxine and acute enteric tryptophan on pyridoxine status, glycemia and insulinemia stimulated by enteric glucose in weanling piglets

From Tryptophan to Hydroxytryptophan: Reflections on a Busy Life

Effects of water supplementation with tryptophan and vitamin B6 or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs

Contact Info

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Resources

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Effects of water supplementation with tryptophan and vitamin B₆ or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs