Dietary quercetin abrogates hepatorenal oxidative damage associated with dichloromethane exposure in rats

Abstract

Exposure to dichloromethane (DCM), a commonly used chlorinated solvent in industrial settings and for the production of many household products, reportedly elicits detrimental effects in animals and humans. The present study investigated the protective role of dietary quercetin on DCM-induced hepatorenal damage in rats. Experimental rats were orally administered with DCM (150 mg/kg) and 30 min later with quercetin at 10, 20 and 40 mg/kg or none for 7 consecutive days. The results indicated that DCM-mediated significant (p<0.05) increases in serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase and alkaline phosphatase activities as well as urea and creatinine levels were dose-dependently normalized to the control values in rats co-treated with quercetin. Further, quercetin co-treatment ameliorated DCM-mediated decrease in the hepatic and renal activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase as well as glutathione level in the treated rats. Moreover, quercetin co-treatment markedly reduced lipid peroxidation level and protected against histological changes in liver and kidney of the treated rats. Taken together, quercetin abrogated hepatorenal oxidative damage in DCM-treated rats via improvement of antioxidant status and suppression of oxidative damage.

Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

“…Quercetin, also known as 3,5,7,3′,4′-pentahydroxyflavone, is a natural flavonoid compound. In nature, it exists in various forms in different plants and can be found as either quercetin aglycone or derivatives, while the most abundant form in the diet is glycosides (Owumi et al, 2019). Quercetin is highly soluble in lipids and alcohol.…”

Rutin ameliorates copper sulfate‐induced brain damage via antioxidative and anti‐inflammatory activities in rats

“…The chemoprotective effect of various polyphenolic compounds has been widely reported [ 29‐33 ] against cellular injury. Polyphenol confers protective benefits against chemical damage to cells, [ 34‐36 ] disease onsets such as cancer, [ 37,38 ] and neurological syndromes. [ 39‐41 ] Rutin, a flavonol glycoside is present in numerous plants and vegetables, [ 38 ] flavonol help in the revival of body cells, disinfects, and perform anti‐inflammatory, antidepressant, and antiviral function.…”

Effect of Blend of Metanil Yellow and Tartrazine on Different Organs of Albino Rat

“…This is consistent with the results of El-Nekeety et al's study, which reported that treatment with quercetin at two tested doses 50, and 100 mg/kg BW overcome the biochemical and histological changes in a dose-dependent manner in rats fed aflatoxin-contaminated diet [5]. This is also inconsistent with Owumi et al's study, which stated that treatment with 40 mg/kg quercetin in dichloromethane-treated rats caused significantly decreased near-normal values of the serum ALT, AST [21].…”

“…Our results are inconsistent with the results of Himri et al, and Abo EL-Sooud et al's study, where a significant increase was observed in serum creatinine but serum urea concentration showed no significant increase after treatment with 3, 7.5 mg/kg tartrazine. These results referred to a low dose of the used tartrazine [17][18][19][20][21][22][23].…”