Rutin ameliorates copper sulfate‐induced brain damage via antioxidative and anti‐inflammatory activities in rats

Abstract

Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu‐induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu‐sulfate: 200 mg/kg; group III: Cu‐sulfate, and rutin 100 mg/kg; and group IV: rutin 100 mg/kg, for 7 weeks. Cu only treatment significantly decreased body weight gain, while rutin cotreatment reversed this decrease. Cu treatment increased malondialdehyde, nitric oxide level, and myeloperoxidase activity and decreased superoxide dismutase and catalase activities in rat brain. Immunohistochemistry showed that COX‐2, iNOS, and Bcl‐2 proteins were strongly expressed, while Bax was mildly expressed in the brain of Cu‐treated rats. Furthermore, brain histology revealed degenerated neurons, and perforated laminae of cerebral cortex in the Cu‐only treated rats. Interestingly, coadministration of Cu and rutin reduced the observed histological alteration, improved inflammatory and antioxidant biomarkers, thereby protecting against Cu‐induced brain damage via antioxidative and anti‐inflammatory mechanisms.

Strawberry fruit ( Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury

“…This corroborates with previous reports on the antioxidative and anti‐inflammatory activities of strawberries (Erukainure, Salau, Oyenihi, et al., 2020; Giampieri et al., 2014; Rutledge et al., 2019). These activities can be attributed to the HPLC‐identified phenolics (Table 1) as they have been well documented for their potent antioxidative and anti‐inflammatory activities (Arowoogun et al., 2021; Salau et al., 2021; Salau et al, 2020).…”

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

“…In an earlier study, psoralen isolated from Dystaenia takeshimana was reported to inhibit COX-2/5-LOX in mouse bone marrow-derived mast cells [33]. A few studies suggest that psoralen derivatives [34,35] and rutin [36][37][38] possess COX-2 inhibitory activity. For instance, 5-methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen from Angelica dahurica was reported to inhibit induction of COX-2 in bone marrow-derived mast cells [34].…”

Combine effect of exposure to petrol, kerosene and diesel fumes: On hepatic oxidative stress and haematological function in rats

“…The level of hepatic NO was assessed using Griess reagent, as previously described by Green et al (Arowoogun et al, 2021; Green et al, 1982). Briefly, the reaction mixture containing equal parts of sample and Griess reagent was incubated for 15 min, and the absorbance was taken at 540 nm.…”