Dietary quercetin maintains the semen quality in rabbits under summer heat stress

Naseer, Zahid; Ahmad, Ejaz; Şahiner, Hande Sultan; Epikmen, Erkmen Tuğrul; Fiaz, Muhammad; Yousuf, M. R.; Khan, Shahzad Akbar; Serin, İlker; Ceylan, Ahmet; Aksoy, Melih

doi:10.1016/j.theriogenology.2018.09.009

Cited by 15 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This experiment was the sequel to a previous study conducted by Naseer et al (2018) on a rabbit semen response after quercetin supplementation, which reported that provision of quercetin would potentially improve the semen quality under summer HS. In the present study, dietary quercitin provision sustained the testicular morphology in rabbit exposed to HS.…”

Section: Discussionmentioning

confidence: 95%

“…The left cauda epididymis was immersed in TCG solution (Tris 276.5 mM, Citric acid 90.9 mM and Glucose 76.8 mM), minced finely and epididymal remnants were removed from the solution. The retrieved sperm were used for motility, viability mitochondrial potential and acrosome reaction, adopting the procedure mentioned in previous studies (Naseer et al, 2018).…”

Section: Evaluation Of Sperm Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

et al. 2020

View full text Add to dashboard Cite

<p>The current study was designed to determine the effects of dietary quercetin on epididymal sperm and testicular changes in male rabbits during summer heat stress (HS). Twelve adult male New Zealand white rabbits were submitted to summer heat conditions (temperature-humidity index 29.9±1.2). One group was fed a basal ration (BR; n = 6), whereas the other group was fed the same basal diet supplemented with quercetin (30 mg/kg d; Que-BR; n = 6) for 60 d, and both groups were sacrificed at the end of the experiment. Epididymis and testicles isolation was done for sperm, histopathology and apoptosis assessments. The results showed that quercetin improved epididymis weight, but did not affect other testicular dimensions except testicular length. A significant improvement was observed in epididymal sperm motility, concentration, kinematic parameters, viability, mitochondrial potential and acrosome integrity in Que-BR compared to the BR group. Lowered serum malondialdehyde level was observed in quercetin supplemented rabbits. Moreover, the quercetin supplementation maintained the interstitial stroma, seminiferous tubules architecture, germinal and Sertoli cells under HS, decreasing the apoptotic germ cell rate in seminiferous tubules. In conclusion, HS condition affects the sperm and testes configurations in rabbits and dietary quercetin minimises oxidative stress, which in turn protects the testes and sperm against HS induced damage.</p>

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Evaluation Of Sperm Characteristicsmentioning

confidence: 99%

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[ 37 ] Que could protect the sperm viability and structural integrity, reduce the effects of heat stress, and maintain sperm quality via relieving the oxidative stress in mice and rabbits. [ 38,39 ] Dietary supplementation of Que could promote follicular growth and increase GC viability in heat‐stressed rabbits. [ 40 ] An appropriate dose of Que could be used as a kind of natural antioxidant in various cell types.…”

Section: Discussionmentioning

confidence: 99%

Quercetin alleviated H₂O₂‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells

Yang

et al. 2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Quercetin (Que) is a natural flavonoid in most plants. Luteinized granulosa cell (LGC) culture is necessary for the study of follicle growth/differentiation. In the present study, we analyzed the role of Que in steroid production and apoptosis in hydrogen peroxide (H2O2)‐treated goat LGCs. The results showed that treatment with H2O2 induced apoptosis in goat LGCs, and treatment with Que decreased LGC apoptosis induced by H2O2 (P < .05), accompanied with the different expressions of BAX, BCL‐2, Caspase 3, and Cleaved caspase 3. Meanwhile, the messenger RNA expressions of nuclear factor erythroid 2 like 2 (Nrf2) and its downstream genes were upregulated with H2O2 +Que treatment, accompanied by the increased cellular viability (P < .05). Furthermore, Que alleviated H2O2‐induced reduction in the secretion of progesterone (P4) (P < .05); however, it had no effect on the secretion of estrogen (E2). Simultaneously, the expressions of StAR and P450scc were increased when treated with Que +H2O2, compared with the group treated with only H2O2 (P < .05). In conclusion, it is observed that Que could alleviate the H2O2‐induced apoptosis and steroidogenic impairment in goat LGCs, which might be mediated by the Nrf2 pathway.

show abstract

“…Animal studies including a wide variety of species including buffalo, rooster, rat, rabbit, bull and goat also found a positive effect of quercetin on sperm cells 16,18,19,20,21,22,23,24 except 2 studies including equine in which they observed no effect 24 and mice in which it is suggested to induce sperm abnormalities. 28 Abdallah et al reported that quercetin may prevent the adverse effects of oxygen radicals, improve the functional parameters of spermatozoa, reduce the levels of lipid peroxidation and increase antioxidant levels in rats.…”

Section: Variablementioning

confidence: 99%

“…14 The effects of quercetin on sperm viability and motility were studied in several animal and human studies with controversial results. Some of these studies concluded that quercetin has a protective or beneficial effect on sperm functions and fertility preservation in several species including mouse 15 , human 16 , buffalo 17 , rooster 18 , rats 19 , rabbit 20 , bull 21 , goat 22 , rabbit 23 , while the others have shown no effect in equine 24 or negative effect in humans. 8 Most of these studies have focused on the effect of quercetin as a cryoprotectant during freezing or cold storage.…”

Section: Variablementioning

confidence: 99%

Quercetin enhances human sperm motility in a dose and time dependent manner

Karabulut¹,

Korkmaz²,

Altun³

et al. 2020

actapharm

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of quercetin on the motility of ejaculated human spermatozoa in asthenozoospermic cases by using different doses and exposure times. Semen samples of 94 men were incubated with quercetin at different doses and durations. Sperm motility was analysed in each group, and the results were compared. Compared to control, Quercetin improved sperm motility in each molarity and each interval except 1M. Statistically significant increase was assessed at 0.05 M after 1 hours of incubation, and 0.1 M after two hours of incubation (p<0.05). According to our results, it can be suggested that quercetin has a positive effect on sperm motility on a dose and time dependent manner. This study provides evidence for the potential use of quercetin for sperm preparation to be used in assisted reproduction techniques especially in cases of asthenozoospermia.

show abstract

Dietary quercetin maintains the semen quality in rabbits under summer heat stress

Cited by 15 publications

References 31 publications

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

Quercetin alleviated H₂O₂‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells

Quercetin enhances human sperm motility in a dose and time dependent manner

Contact Info

Product

Resources

About

Dietary quercetin maintains the semen quality in rabbits under summer heat stress

Cited by 15 publications

References 31 publications

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells

Quercetin enhances human sperm motility in a dose and time dependent manner

Contact Info

Product

Resources

About

Quercetin alleviated H₂O₂‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells