Dietary Risk Factors and Eating Behaviors in Peripheral Arterial Disease (PAD)

Cecchini, Andrea Leonardo; Biscetti, Federico; Rando, Maria Margherita; Nardella, Elisabetta; Pecorini, Giovanni; Eraso, Luis H.; DiMuzio, Paul; Gasbarrini, Antonio; Massetti, Massimo; Flex, Andrea

doi:10.3390/ijms231810814

Cited by 14 publications

(10 citation statements)

References 676 publications

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“…Atherosclerosis and aortic aneurysm have a regional heterogeneity with the infrarenal region being especially prone, 27,28 and fast food diet consumption is associated with atherosclerosis. 29 Therefore, male cynomolgus monkeys at 5 years of age were provided a high-fructose diet and drink to mimic a fast food and soft drink diet and were terminated 36 months later.…”

Section: Resultsmentioning

confidence: 99%

Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

Ito,

Amioka,

Franklin

et al. 2023

ATVB

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BACKGROUND: The regional heterogeneity of vascular components and transcriptomes is an important determinant of aortic biology. This notion has been explored in multiple mouse studies. In the present study, we examined the regional heterogeneity of aortas in nonhuman primates. METHODS: Aortic samples were harvested from the ascending, descending, suprarenal, and infrarenal regions of young control monkeys and adult monkeys provided with high fructose for 3 years. The regional heterogeneity of aortic structure and transcriptomes was examined by histological and bulk RNA sequencing analyses. RESULTS: Immunostaining of CD31 and αSMA (alpha-smooth muscle actin) revealed that endothelial and smooth muscle cells were distributed homogeneously across the aortic regions. In contrast, elastic fibers were less abundant and dispersed in the infrarenal aorta compared with other regions and associated with collagen deposition. Bulk RNA sequencing identified a distinct transcriptome related to the Notch signaling pathway in the infrarenal aorta with significantly increased NOTCH3 mRNA compared with other regions. Immunostaining revealed that NOTCH3 protein was increased in the media of the infrarenal aorta. The abundance of medial NOTCH3 was positively correlated with the dispersion of elastic fibers. Adult cynomolgus monkeys provided with high fructose displayed vascular wall remodeling, such as smooth muscle cell loss and elastic fiber disruption, predominantly in the infrarenal region. The correlation between NOTCH3 and elastic fiber dispersion was enhanced in these monkeys. CONCLUSIONS: Aortas of young cynomolgus monkeys display regional heterogeneity of their transcriptome and the structure of elastin and collagens. Elastic fibers in the infrarenal aorta are dispersed along with upregulation of medial NOTCH3.

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Section: Resultsmentioning

confidence: 99%

Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

Ito,

Amioka,

Franklin

et al. 2023

ATVB

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“…118,119 Data from the Jackson Heart Study show a significant association between smoking and PAD particularly in African Americans. 120 Other studies suggest that eating saturated fats, sodium, and sugars can increase the risk of PAD, 121 while exercising can reduce risks for PAD. 122 Although PAD is not common during pregnancy, HDP is a risk factor for acquiring PAD later in life.…”

Section: Peripheral Arterial Diseasementioning

confidence: 99%

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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Hypertension is the leading cause of cardiovascular disease in women, and sub-Saharan African (SSA) countries have some of the highest rates of hypertension in the world. Expanding knowledge of causes, management, and awareness of hypertension and its co-morbidities worldwide is an effective strategy to mitigate its harms, decrease morbidities and mortality, and improve individual quality of life. Hypertensive disorders of pregnancy (HDPs) are a particularly important subset of hypertension, as pregnancy is a major stress test of the cardiovascular system and can be the first instance in which cardiovascular disease is clinically apparent. In SSA, women experience a higher incidence of HDP compared with other African regions. However, the region has yet to adopt treatment and preventative strategies for HDP. This delay stems from insufficient awareness, lack of clinical screening for hypertension, and lack of prevention programs. In this brief literature review, we will address the long-term consequences of hypertension and HDP in women. We evaluate the effects of uncontrolled hypertension in SSA by including research on heart disease, stroke, kidney disease, peripheral arterial disease, and HDP. Limitations exist in the number of studies from SSA; therefore, we will use data from countries across the globe, comparing and contrasting approaches in similar and dissimilar populations. Our review highlights an urgent need to prioritize public health, clinical, and bench research to discover cost-effective preventative and treatment strategies that will improve the lives of women living with hypertension in SSA.

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“…Although data on PAD and eating disorders (emotional eating and binge eating) is lacking, its association with PAD occurrence may also be assumed. 65 The regular and supervised training programs that have been highly effective in many PAD patients 66 show limited value with low SES individuals. Low awareness of their benefits, low educational levels, and logistical obstacles are the main reasons for failure.…”

Section: Ses and Pad Carementioning

confidence: 99%

The importance of socio-economic determinants of health in the care of patients with peripheral artery disease: A narrative review from VAS

et al. 2023

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Socio-economic determinants of health (SDoH) include various nonmedical factors in the socio-economic sphere with a potentially significant impact on health outcomes. Their effects manifest through several mediators/moderators (behavioral characteristics, physical environment, psychosocial circumstances, access to care, and biological factors). Various critical covariates (age, gender/sex, race/ethnicity, culture/acculturation, and disability status) also interact. Analyzing the effects of these factors is challenging due to their enormous complexity. Although the significance of SDoH for cardiovascular diseases is well documented, research regarding their impact on peripheral artery disease (PAD) occurrence and care is less well documented. This narrative review explores to what extent SDoH are multifaceted in PAD and how they are associated with its occurrence and care. Additionally, methodological issues that may hamper this effort are addressed. Finally, the most important question, whether this association may contribute to reasonable interventions aimed at SDoH, is analyzed. This endeavor requires attention to the social context, a whole systems approach, multilevel-thinking, and a broader alliance that reaches out to more stakeholders outside the medical sphere. More research is needed to justify the power in this concept to improve PAD-related outcomes like lower-extremity amputations. At the present time, some evidence, reasonable consideration, and intuitive reasoning support the implementation of various interventions in SDoH in this field.

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Dietary Risk Factors and Eating Behaviors in Peripheral Arterial Disease (PAD)

Cited by 14 publications

References 676 publications

Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

The importance of socio-economic determinants of health in the care of patients with peripheral artery disease: A narrative review from VAS

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