Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway

Wang, Yi; Liu, Bingbing; Wu, Peixuan; Chu, Yi; Gui, Sisi; Zheng, Yazhen; Chen, Xiaodong

doi:10.3390/antiox11020349

Cited by 53 publications

(24 citation statements)

References 47 publications

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“…In STZ-induced diabetic rats, dietary supplemented with inorganic selenium for 24 weeks significantly lowered serum glucose concentration ( Becker et al, 1996 ). Additionally, dietary selenium improved glucose intolerance in high-fat diet-fed mice ( Wang et al, 2022 ). However, diabetic rats also showed resistance to selenium, as sodium selenite only decreased glucose concentration for the first two weeks, while they had no further effects for the last four weeks of the experiment ( McNeill et al, 1991 ).…”

Section: Discussionmentioning

confidence: 99%

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Cui

Chen²,

Yang³

2022

Front. Microbiol.

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Either selenium or serine could modulate glucose homeostasis, however, whether there are synergistic effects of selenium with serine on diabetes remains to be unknown. In the present study, eight male db/m mice were used as a control, and 24 male diabetic db/db mice were either orally gavaged with PBS, or with selenomethionine alone, or with both selenomethionine and serine, to investigate the effects of selenomethionine and serine on body weight and glucose level. Furthermore, intestinal microbiota composition was analyzed and fecal microbiota transplantation (FMT) was performed to explore whether microbes mediate the beneficial effects of selenomethionine and serine. The results showed that administration of selenomethionine decreased body weight, adipose tissue weight and serum glucose level in db/db diabetic mice. Importantly, administration of selenomethionine in combination with serine exerted better effects than selenomethionine alone did. Furthermore, a combined administration of selenomethionine and serine restored the microbial composition in diabetic mice. Corynebacterium glutamicum, Bifidobacterium pseudolongum, and Aerococcus urinaeequi were significantly decreased, whereas Lactobacillus murinus was increased in mice in the selenomethionine group and selenomethionine in combination with serine group, when compared with those in the db/db group. FMT decreased body weight and glucose level in db/db mice, further indicating that microbes play critical roles in the beneficial effects of selenomethionine and serine. Thus, we concluded that administration of selenomethionine in combination with serine benefits diabetes via gut microbes. Our results suggested that the synergic application of selenomethionine and serine could be potentially used for the treatment of diabetes.

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Section: Discussionmentioning

confidence: 99%

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Cui

Chen²,

Yang³

2022

Front. Microbiol.

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“…Sep-1 and Sep-2 promoted Nrf2 protein expression and elevated GSH-Px activity and GSH content better than Pep-1 and Pep-2. Wang et al reported that selenium can activate the Nrf2-Keap1 pathway and protect hepatocytes from oxidative stress; 41 and Yi et al demonstrated that soybean peptides can alleviate H 2 O 2 -induced oxidative stress by activating the Nrf2-Keap1 signaling pathway and increasing the activities of intracellular antioxidant enzymes. 40 Our results suggest that selenium and soybean peptides show synergistic effects in activating the Nrf2-Keap1 signaling pathway.…”

Section: Resultsmentioning

confidence: 99%

Selenium-enriched peptides identified from selenium-enriched soybean protein hydrolysate: protective effects against heat damage in Caco-2 cells

et al. 2023

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“…Usually, Selenium was recognized as antioxidants to attenuate the development of NAFLD [ 43 ]. Yang Yi [ 44 ] and Seyedeh [ 45 ] et al. found high selenium exposure decreased liver steatosis, HOMA-IR, LDL/HDL-c and TC/HDL-c ratios which were aetiologies of NAFLD in NAFLD rodent models via directly suppling high-fat diets (HBD) with added selenomethionine.…”

Section: Discussionmentioning

confidence: 99%

The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018

et al. 2022

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Background & Objective Selenium was one of the essential trace elements that played a pivotal role in human health. Although previous studies have investigated the relationship between selenium and non-alcoholic fatty liver disease (NAFLD) and fibrosis, these findings were still inconclusive. Our study was aimed to explore the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by vibration controlled transient elastography (VCTE) in US adults. Methods All data were extracted from National Health and Nutrition Examination Survey database (2017–2018). Participants were divided into four groups according to quartile of blood selenium level. Liver stiffness and controlled attenuation parameter (CAP) were measured by VCTE. Multiple logistic regression models and subgroup analyses were conducted to determine the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by a variety of methods. Results A total of 3336 participants were enrolled in main analysis. In multiple logistic regression models, the higher blood selenium level (>205.32, ≤453.62 μg/L) had a significant positive association with NAFLD (β = 1.31). Moreover, high blood selenium level had significantly inversely association to advanced liver fibrosis (β = 0.61). In subgroup analysis, the main inversely correlation between blood selenium and advanced liver fibrosis was found in males with high blood selenium level. Despite dietary selenium intake being adjusted or in different subgroups, the associations between blood selenium level and NAFLD/advanced liver fibrosis remained significant. Conclusions This study showed that blood selenium level were positively association with NAFLD among US population. Participants with lower blood selenium level showed a higher percentage of advanced liver fibrosis. Blood selenium is more likely to cause NAFLD and liver fibrosis due to imbalances in selenium homeostasis rather than dietary selenium intake. Key messages High blood selenium level was association with NAFLD diagnosed by vibration controlled transient elastography. Participants with lower blood selenium level had high percentage of advanced liver fibrosis. NAFLD and liver fibrosis are caused by an imbalance of selenium homeostasis, not by dietary selenium intake.

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Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway

Cited by 53 publications

References 47 publications

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Selenium-enriched peptides identified from selenium-enriched soybean protein hydrolysate: protective effects against heat damage in Caco-2 cells

The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018

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