Dietary Serine and Sulfate-Containing Amino Acids Related to the Nutritional Status of Selenium in Lactating Chinese Women

Han, Feng; Pang, Xuewen; Wang, Qin; Liu, Yiqun; Liu, Liping; Chai, Yingjuan; Zhang, Jie; Wang, Shijin; Lu, Jiaxi; Sun, Lingyun; Zhan, Shuo; Wu, Hongying; Huang, Zhiming

doi:10.1007/s12011-020-02204-w

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…Moreover, sulfurcontaining amino acids can form many derivatives, the most representative of which is glutathione. Glutathione has a reducing effect on the peroxide and reactive oxygen produced by various phagocytes such as neutrophils and macrophages in the process of exerting their effects, and plays an important role in preventing the destruction of cells by peroxides [176,177]. Reasonable supplementation of amino acids with immune regulation functions plays an important role in maintaining a moderate immune response.…”

Section: Amino Acidsmentioning

confidence: 99%

The cancer metabolic reprogramming and immune response

et al. 2021

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The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider implications in the regulation of antitumor immune response through both the release of metabolites and affecting the expression of immune molecules, such as lactate, PGE2, arginine, etc. Actually, this energetic interplay between tumor and immune cells leads to metabolic competition in the tumor ecosystem, limiting nutrient availability and leading to microenvironmental acidosis, which hinders immune cell function. More interestingly, metabolic reprogramming is also indispensable in the process of maintaining self and body homeostasis by various types of immune cells. At present, more and more studies pointed out that immune cell would undergo metabolic reprogramming during the process of proliferation, differentiation, and execution of effector functions, which is essential to the immune response. Herein, we discuss how metabolic reprogramming of cancer cells and immune cells regulate antitumor immune response and the possible approaches to targeting metabolic pathways in the context of anticancer immunotherapy. We also describe hypothetical combination treatments between immunotherapy and metabolic intervening that could be used to better unleash the potential of anticancer therapies.

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Section: Amino Acidsmentioning

confidence: 99%

The cancer metabolic reprogramming and immune response

et al. 2021

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“…Our previous result showed serine played a direct role in selenoprotein expression through the de novo biosynthesis of Sec-tRNA [Ser]Sec in vitro ( 2 ); this was also supported in vivo by other studies ( 34 , 35 ). Dietary serine and sulfur-containing AAs were found to have a direct effect on the nutritional status of lactating Chinese women ( 5 ); thus a high protein intake or low plasma SEPP1 may pose as health risks in this population. TG and TCHO of male rats were decreased due to serine deprivation, but there were no changes in the pregnant mice in Experiment 2.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the addition of serine in the maternal diet during the third trimester and subsequent lactation resulted in a greatly improved Se nutritional status in both sows and their offspring, in which may result in higher body weight offsprings ( 4 ). We have recently reported that the total amount of serine from dietary protein intake daily was associated with the nutritional status of Se in Chinese lactating women living in the traditional endemic areas of Keshan diseases ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of insufficient serine on health and selenoprotein expression in rats and their offspring

Liu

Wang

et al. 2022

Front. Nutr.

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ObjectiveTo observe the impact of insufficient exogenous and/or endogenous serine on selenoprotein expression and health of pregnant rats and their offspring.MethodExperiment 1 was conducted in male rats, in which the dose-dependent effects of serine on selenoprotein expression and thyroid hormones (T3, T4 and TSH) were investigated by feeding either a serine adequate diet (20C), serine-deprived diet (20CSD) or 20CSD with different serine levels (0.5, 1.0, and 2.0 times the amount of serine in 20C). In experiment 2, a PHGDH inhibitor was administrated to pregnant rats fed either 20C or 20CSD. Blood and organ tissues of pregnant rats and offspring were subjected to the analyses of thyroid hormone, serine and homocysteine and GPx3 and SELENOP in plasma and expression of GPx1 and DIO1, 2 in tissues respectively.ResultIn experiment 1, plasma SELENOP and GPx3 levels in adult male rats increased with the increasing dose of serine. Immunohistochemical results showed that GPx1 expression in liver and kidney of male rats also increased with increasing serine supplementation. Amongst all diet groups, only male rats fed 20CSD had significantly lower plasma TSH and T4 levels (P < 0.05). In experiment 2, GPx1 and DIO2 expression in the liver and kidney were suppressed in pregnant rats administered with a PHGDH compared to those who were not (P < 0.05). There were no significant differences in plasma T4 and T3 amongst all diet groups (P > 0.05). Also, offspring born to pregnant rats administered with a PHGDH inhibitor exhibited slower growth rates and hyperhomocysteinemia compared to offspring from mothers not administered with the inhibitor (P < 0.05). Conclusions: Insufficient exogenous serine through the diet decreased selenoprotein synthesis in adult male rats. However, this was not observed in pregnant rats, whereby exogenous or endogenous serine deficiency had no effect on the selenoprotein levels. A possible explanation is that dams may have an adaptive mechanism to limit maternal serine utilization and ensure adequate supply to the fetus.

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