Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets1–3

Huang, Chi‐Kuang; Song, Peixia; Fan, Peixin; Hou, Chengli; Thacker, P. A.; Ma, Xi

doi:10.3945/jn.115.217406

Cited by 224 publications

(217 citation statements)

References 42 publications

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“…Wang et al 34 have observed that sodium butyrate induced increase in gene expression and protein content of claudin-1 in the intestinal epithelial cell line IEC, possibly due to a higher level of interaction between the SP1 transcription factor, and its promoter. Additionally, Huang et al 70 reported that the decrease in paracellular intestinal permeability, as measured by lactulose/mannitol assay in urine, is associated with increased expression of occludin in jejunum and colon segments of newborn pigs after butyrate treatment in combination with antibiotics. The authors suggested that this effect on intestinal function was probably due to an anti-inflammatory action of this SCFA since the TNF-a concentration was lower in the mucosa of animals receiving treatment with butyrate.…”

Section: Discussionmentioning

confidence: 99%

“…The authors suggested that this effect on intestinal function was probably due to an anti-inflammatory action of this SCFA since the TNF-a concentration was lower in the mucosa of animals receiving treatment with butyrate. 70 The mechanism of action of sodium butyrate on cellular expression of claudin-1 or other structural proteins of TJ is still unknown; however, it may also be related to its action as an inhibitor of the HDAC enzyme. Sodium butyrate causes hyperacetylation of histones by inhibiting histone affinity with DNA and thus increases the exposure of regions for transcription of certain genes.…”

Section: Discussionmentioning

confidence: 99%

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Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

Matheus

Monteiro

Oliveira

et al. 2017

Exp Biol Med (Maywood)

130

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Butyrate is a short-chain fatty acid produced by the intestinal microbiota through the fermentation of non-absorbable carbohydrates and proteins (e.g. fibers). Sodium butyrate incorporated into the diet displayed a protective action on metabolic, hepatic, pancreatic and intestinal alterations induced by high-fat diet in mice, resulting in significant inhibition of the development of a prediabetic state. Thus, our data suggest that butyrate may have a potential therapeutic use in the treatment of type 2 diabetes and related disorders. AbstractIn this study, we investigated the effect of diet supplementation with sodium butyrate (5% w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters, body adiposity, hepatic and pancreatic lipid accumulation, beta cell function/mass as well as on the structure and function of the tight junction-mediated intestinal epithelial barrier in both normal and obese/prediabetic C57 mice fed a regular (control) or high-fat diet for 60 days, respectively. Butyrate treatment significantly inhibited all the high-fat-induced metabolic dysfunctions evaluated, i.e. significantly reduced the weight gain and body adiposity as well as the insulin resistant state, hyperglycemia and hyperinsulinemia, without changing food intake. In addition, high-fat-fed mice treated with this short-chain fatty acid displayed no compensatory hyperplasia of pancreatic beta cells nor marked hepatic steatosis as seen in prediabetic mice after high-fat diet only. Isolated pancreatic islets from high-fat-fed mice treated with butyrate showed improvement of the insulin secretion, which was associated with a significant decrease in lipid accumulation within the pancreas. Butyrate enhanced the intestinal epithelial barrier, as revealed by the FITC-Dextran permeability assay, which was accompanied by a significant increase in the junctional content of the tight junction-associated claudin-1 in intestinal epithelia of jejunum, ileum, and colon of both control and high-fat mice. In conclusion, our results showed that diet supplementation with butyrate inhibits the deleterious effects of high-fat diet intake on metabolic parameters and structure/function of several tissues/ organs associated with type 2 diabetes mellitus in a mouse model, suggesting a potential use of this short-chain fatty acid in the treatment of this endocrine-metabolic disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

Matheus

Monteiro

Oliveira

et al. 2017

Exp Biol Med (Maywood)

130

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“…Suplementacja diety maśla-nem sodu zwiększa ekspresję okludyny, czyli białka modelującego przepuszczalność jelitową. To powoduje wzmocnienie integralności nabłonka jelit i przyspiesza proces gojenia się ran (18,28). Zastosowanie maślanu sodu wpływa na zmniejszenie udziału związanego z procesem zapalnym czynnika martwicy nowotworu TNF-α o 69%.…”

Section: Ryc 2 Mechanizm Działania Kwasu Organicznego Na Komórkę Baunclassified

“…Zauważono także spadek populacji bakterii z rodzaju Clostridium w okrężnicy, co ograniczyło często-tliwość występowania biegunek u odsadzonych prosiąt (tab. 1) (18). Ponadto, maślan sodu indukuje ekspresję niektórych peptydów przeciwbakteryjnych (HDP -Host Defence Peptides) w komórkach nabłonkowych jelit.…”

Section: Ryc 2 Mechanizm Działania Kwasu Organicznego Na Komórkę Baunclassified

Organic acids in piglet nutrition – a review

Woźniakowska

Kozera

Karpiesiuk

2017

Medycyna Weterynaryjna

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SummaryThe risk of developing cross-resistance of pathogens to antibiotics led to a ban on antibiotics as growth promoters in animal feed in the European Union since January 2006. In recent decades, acidifiers have been widely used as potential alternatives to antibiotics in the nursery pigs' diet to overcome weaning stresses, prevent intestinal disturbances with diarrhea and to improve growth performance. Organic acids can reduce the digesta pH value in the gastrointestinal tract (GIT), converting the inactive pepsinogen to active pepsin and increase the protein utilization. Acidifiers also promote beneficial microbial growth in the GIT and reduce infection from harmful microorganisms. Moreover, dietary inclusion of organic acids and their salts for weaning pigs can reduce intestinal epithelia damage, increase intestinal occludin expression and decrease small intestinal permeability, and improve immune indexes. In conclusion, dietary supplementation with acidifiers can decrease economic loss for pig producers.

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“…Phy and Provenza (1998) illustrated that small ruminants preferred pelletized fermentable concentrate diets supplemented with sodium bicarbonate. Dietary sodium butyrate decreased digestive tract permeability and facilitated considerable alterations in intestinal microbial population (Huang et al, 2015) in addition to reducing colonic inflammation (Wirtz and Neurath, 2007).…”

Section: Introductionmentioning

confidence: 99%

High Grain Diet Triggers Inflammation in the Goat Uterus: A Comprehensive Regulation Diet Modulates the Immune Response

Bilal¹,

Abaker²,

Aabdin³

et al. 2017

IJAB

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The aim of the present study was to explore the causal association between the increase in circulating subacute ruminal acidosis (SARA)-induced lipopolysaccharide (LPS) levels and uterine inflammation; moreover this study sought to evaluate the role of a comprehensive regulation diet in combating the inflammatory effects of a high grain diet. Twelve dairy goats were randomly assigned to two groups. One group was provided a high-concentrate buffered diet as the comprehensive regulation group (RG) control while, only a high concentrate powdered diet was fed to the treatment group (TG). The LPS concentrations in the rumen fluid were 428702±34505.6 and 255027±39756.2 EU/mL, in the TG and RG goats, respectively, while, the LPS levels in the peripheral plasma were 0.032±0.003 and 0.012±0.003 EU/mL in the TG and RG goats, respectively. The concentration of TNF-α, IL-1β and IL-6 was significantly higher, and there was enhanced expression of the inflammatory genes TLR4, MyD88, TRAF-6, NF-κB, IL-1β and IL-6 in the uteri of TG goats. SARA increased the NF-κB expression and level of its phosphorylated form in TG goats. The uteri of TG goats showed higher mRNA levels of proinflammatory genes than the RG goats, indicating the presence of inflammation. Thus, SARA-induced LPS derived from a high concentrate diet triggers inflammation in the goat uterus by reinforcing TLR4 signaling.

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Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets1–3

Abstract: Collectively, our results support an important role for SB in improving performance and decreasing diarrhea incidence in weaned piglets by modulation of intestinal permeability and the bacterial communities in the ileum and colon.

Cited by 224 publications

References 42 publications

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

Organic acids in piglet nutrition – a review

High Grain Diet Triggers Inflammation in the Goat Uterus: A Comprehensive Regulation Diet Modulates the Immune Response

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