Dietary sources, health benefits, and risks of caffeine

Saimaiti, Adila; Zhou, Dan-Dan; Li, Jiahui; Xiong, Ruo-Gu; Gan, Ren‐You; Huang, Siyu; Shang, Ao; Zhao, Cong; Li, Hangyu; Li, Hua Bin

doi:10.1080/10408398.2022.2074362

Cited by 41 publications

(16 citation statements)

References 154 publications

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“…The anticancer effects of natural products have become a research hotspot, due to their low or non-toxicity. Many studies showed that natural compounds from fruits, vegetables, tea, coffee, spices, and medicinal plants could play an important role in the prevention and treatment of cancers with different mechanisms of action [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.

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Section: Introductionmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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“…In addition, a meta-analysis showed those who consume three to five cups of caffeinated coffee a day have lower incidence of coronary artery disease, stroke and death due to cardiovascular causes [ 130 ]. However, longer-term or overconsumption of caffeine may cause addiction, insomnia, migraine and other adverse effects [ 131 ].…”

Section: Health Benefits Of Compounds In Scgmentioning

confidence: 99%

The Potential of Spent Coffee Grounds in Functional Food Development

et al. 2023

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Coffee is a popular and widely consumed beverage worldwide, with epidemiological studies showing reduced risk of cardiovascular disease, cancers and non-alcoholic fatty liver disease. However, few studies have investigated the health effects of the post-brewing coffee product, spent coffee grounds (SCG), from either hot- or cold-brew coffee. SCG from hot-brew coffee improved metabolic parameters in rats with diet-induced metabolic syndrome and improved gut microbiome in these rats and in humans; further, SCG reduced energy consumption in humans. SCG contains similar bioactive compounds as the beverage including caffeine, chlorogenic acids, trigonelline, polyphenols and melanoidins, with established health benefits and safety for human consumption. Further, SCG utilisation could reduce the estimated 6–8 million tonnes of waste each year worldwide from production of coffee as a beverage. In this article, we explore SCG as a major by-product of coffee production and consumption, together with the potential economic impacts of health and non-health applications of SCG. The known bioactive compounds present in hot- and cold-brew coffee and SCG show potential effects in cardiovascular disease, cancer, liver disease and metabolic disorders. Based on these potential health benefits of SCG, it is expected that foods including SCG may moderate chronic human disease while reducing the environmental impact of waste otherwise dumped in landfill.

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“…Over the years, the efficacy of caffeine as a countermeasure for sleepiness has been well-established [ 14 , 15 , 16 , 17 ]. It is worth noting that a moderate caffeine intake can combat sleep deprivation and increase alertness and concentration, while an excessive caffeine consumption increases sleep pressure and decreases sleep quality [ 18 , 19 ]. Therefore, people should consume caffeine in moderation and, importantly, at an appropriate time.…”

Section: Introductionmentioning

confidence: 99%

Caffeine-Induced Sleep Restriction Alters the Gut Microbiome and Fecal Metabolic Profiles in Mice

Song

Liu

et al. 2022

IJMS

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Insufficient sleep is becoming increasingly common and contributes to many health issues. To combat sleepiness, caffeine is consumed daily worldwide. Thus, caffeine consumption and sleep restriction often occur in succession. The gut microbiome can be rapidly affected by either one’s sleep status or caffeine intake, whereas the synergistic effects of a persistent caffeine-induced sleep restriction remain unclear. In this study, we investigated the impact of a chronic caffeine-induced sleep restriction on the gut microbiome and its metabolic profiles in mice. Our results revealed that the proportion of Firmicutes and Bacteroidetes was not altered, while the abundance of Proteobacteria and Actinobacteria was significantly decreased. In addition, the content of the lipids was abundant and significantly increased. A pathway analysis of the differential metabolites suggested that numerous metabolic pathways were affected, and the glycerophospholipid metabolism was most significantly altered. Combined analysis revealed that the metabolism was significantly affected by variations in the abundance and function of the intestinal microorganisms and was closely relevant to Proteobacteria and Actinobacteria. In conclusion, a long-term caffeine-induced sleep restriction affected the diversity and composition of the intestinal microbiota in mice, and substantially altered the metabolic profiles of the gut microbiome. This may represent a novel mechanism by which an unhealthy lifestyle such as mistimed coffee breaks lead to or exacerbates disease.

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Dietary sources, health benefits, and risks of caffeine

Cited by 41 publications

References 154 publications

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

The Potential of Spent Coffee Grounds in Functional Food Development

Caffeine-Induced Sleep Restriction Alters the Gut Microbiome and Fecal Metabolic Profiles in Mice

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