Dietary stearic acid regulates mitochondria in vivo in humans

Tiebe, Deniz Senyilmaz; Pfaff, Daniel; Virtue, Sam; Schwarz, Kathrin; Fleming, Thomas; Altamura, Sandro; Muckenthaler, Martina U.; Okun, Jürgen G.; Vidal-Puig, António; Nawroth, Peter P.; Teleman, Aurelio A.

doi:10.1038/s41467-018-05614-6

Cited by 100 publications

(74 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that the extent of mitochondrial fusion differed between adipocytes pre-enriched with different FA indicates that this process can be modulated according to single metabolites. This has been shown to be the case in humans, where ingestion of the FA stearic acid (18:0) caused mitochondrial fusion within 3 h after ingestion, whereas this response was not observed after PA ingestion [61]. Our results showed that OA and EPA had a greater capacity than PA to promote mitochondrial dynamics in Atlantic salmon adipocytes.…”

Section: Mitochondrial Responses In Adipocytes Enriched With Oa Pa supporting

confidence: 66%

Lipid Deposition and Mobilisation in Atlantic Salmon Adipocytes

Bou

Wang

Todorčević

et al. 2020

IJMS

View full text Add to dashboard Cite

The present study aimed to elucidate how Atlantic salmon adipocytes pre-enriched with palmitic (16:0, PA), oleic (18:1n−9, OA), or eicosapentaenoic (20:5n−3, EPA) acid respond to a fasting condition mimicked by nutrient deprivation and glucagon. All experimental groups were supplemented with radiolabeled PA to trace secreted lipids and distribution of radioactivity in different lipid classes. There was a higher content of intracellular lipid droplets in adipocytes pre-enriched with OA than in adipocytes pre-enriched with PA or EPA. In the EPA group, the radiolabeled PA was mainly esterified in phospholipids and triacylglycerols, whereas in the OA and PA groups, the radioactivity was mainly recovered in phospholipids and cholesterol-ester. By subjecting the experimental groups to nutrient-deprived media supplemented with glucagon, lipolysis occurred in all groups, although to a lower extent in the OA group. The lipids were mainly secreted as esterified lipids in triacylglycerols and phospholipids, indicating mobilization in lipoproteins. A significant proportion was secreted as free fatty acids and glycerol. Leptin secretion was reduced in all experimental groups in response to fasting, while the mitochondria area responded to changes in the energy supply and demand by increasing after 3 h of fasting. Overall, different lipid classes in adipocytes influenced their mobilization during fasting.

show abstract

Section: Mitochondrial Responses In Adipocytes Enriched With Oa Pa supporting

confidence: 66%

Lipid Deposition and Mobilisation in Atlantic Salmon Adipocytes

Bou

Wang

Todorčević

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…47 Another compound identified was stearic acid, which is associated with reduced cardiovascular and cancer risks. 48 Palmitic acid, present in both species, has induced senescence in hepatocellular cells and also impairs the expression of the SMARCD1 gene, which appears to be responsible for the accumulation of lipids associated with aging in the hepatic cell. 49 Squalene and α-amyrin, together with other compounds present in Wrightia pubescens extracts, were effective against HT-29 (cell line colon) with an IC 50 of 1.70 μg mL −1 .…”

Section: Cytotoxicitymentioning

confidence: 99%

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Guedes¹,

Filho²,

Silva³

et al. 2020

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds.

show abstract

“…The differences in the chain length of the FFAs could also cause opposite metabolic consequences when ingested. Palmitic acid (C16:0) uptake can increase low-density lipoprotein (LDL) cholesterol level as well as atherosclerosis risks, whereas stearic acid has the exact opposite effect 4 . Clearly, the structures and associated intermolecular interactions in various FFAs plays a significant role on physiological behaviour, and additionally these phenomena are of great importance in other fields, such as the pharmaceutical, cosmetics, and food industries 5 .…”

mentioning

confidence: 99%