Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

Aragno, Manuela; Mastrocola, Raffaella

doi:10.20944/preprints201702.0047.v1

Cited by 41 publications

(1 citation statement)

References 89 publications

(112 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Por otro lado, la forma que carece de la cola citosólica, pero permanece incrustada en la membrana donde se une a los AGEs (C-terminal) funciona como un RAGE dominante-negativo. Incapaz de transducir una señal celular en la unión del ligando (16,30,31). Las formas secretadas de RAGE no inducen la activación de vías relacionadas a la unión con ligando, debido a que carecen de los dominios transmembranal y citoplasmático, siendo denominados inhibidores competitivos de la unión de AGE con RAGE, contrarrestando su acción deletérea (29).…”

Section: Rage Estructura E Isoformasunclassified

Receptor de los productos finales de glicación avanzada (RAGE) como biomarcador de la obesidad infantil

Vega-Cárdenas,

Vargas-Morales,

Portales-Pérez

et al. 2023

revbiomed

View full text Add to dashboard Cite

Introducción. La hiperglucemia e hiperlipidemia contribuyen a la formación endógena de productos finales de glicación avanzada (AGEs), y la dieta constituye parte de las fuentes exógenas. La unión de AGEs al receptor de los productos finales de glicación (RAGE), induce vías de señalización que culminan en la activación de factores de transcripción que promueven la expresión de marcadores inflamatorios y de estrés oxidativo. Los niveles de RAGE soluble (sRAGE) han sido propuestos como biomarcador en enfermedades que cursan con un proceso inflamatorio. Diversos estudios describen el papel de RAGE en la obesidad, por lo que se ha discutido si existe un patrón diferencial entre niños con normo peso y obesidad. Objetivo. Describir la relación entre RAGE, sus isoformas, ligandos, funciones biológicas, y las comorbilidades relacionadas con la obesidad infantil. Determinar si los niveles disminuidos de sRAGE representan un biomarcador de la obesidad infantil con base en los resultados de estudios clínicos, observacionales y transversales. Metodología. Revisión descriptiva de estudios publicados en el periodo del año 2016 al 2022 en las bases de datos PubMed y Google Académico empleando los términos “AGEs”, “RAGE”, “sRAGE”, y “obesidad infantil”. Resultados y conclusiones. Fueron consultados un total de 141 artículos relacionados con las palabras clave. El criterio de eliminación consistió en referencias publicadas antes del 2015, con excepción de las referencias clásicas. Se revisaron 63 artículos de 2016 a 2022, 6 representan estudios transversales sobre los niveles de sRAGE en población pediátrica, encontrando diferencias en la expresión de RAGE de acuerdo con el estado nutricional

show abstract

Section: Rage Estructura E Isoformasunclassified

Receptor de los productos finales de glicación avanzada (RAGE) como biomarcador de la obesidad infantil

Vega-Cárdenas,

Vargas-Morales,

Portales-Pérez

et al. 2023

revbiomed

View full text Add to dashboard Cite

show abstract

Biomarkers of intake for tropical fruits

et al. 2020

View full text Add to dashboard Cite

Consumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a challenge. Due to errors in self-reporting methods, the available dietary information is usually biased. Biomarkers of intake constitute objective tools to better reflect the usual or recent consumption of different foods, including fruits and vegetables. Partners of The Food Biomarker Alliance (FoodBall) Project have undertaken the task of reviewing the available literature on putative biomarkers of tropical fruit intake. The identified candidate biomarkers were subject to validation evaluation using eight biological and chemical criteria. This publication presents the current knowledge on intake biomarkers for 17 tropical fruits including banana, mango, and avocado as the most widely consumed ones. Candidate biomarkers were found only for banana, avocado, and watermelon. An array of banana-derived metabolites has been reported in human biofluids, among which 5hydroxyindole-acetic acid, dopamine sulfate, methoxyeugenol glucuronide, salsolinol sulfate, 6-hydroxy-1-methyl-1,2,3, 4-tetrahydro-β-carboline-sulfate, and other catecholamine metabolites. Their validation is still at an early stage, with insufficient data on dose-response relationship. Perseitol and mannoheptulose have recently been reported as candidate biomarkers for avocado intake, while the amino acid citrulline has been associated with watermelon intake. Additionally, the examination of food composition data revealed some highly specific phytochemicals, which metabolites after absorption may be further studied as putative BFI for one or several tropical fruits. To make the field move forward, untargeted metabolomics, as a data-driven explorative approach, will have to be applied in both intervention and observational studies to discover putative BFIs, while their full validation and the establishment of dose-response calibration curves will require quantification methods at a later stage.

show abstract

Association of major dietary patterns with advanced glycation end products and high-sensitivity C-reactive protein in people with type 1 diabetes mellitus

Ebrahimi

Shojaeian

Amiri

et al. 2023

Nutr J

View full text Add to dashboard Cite

Background The associations of diet with serum levels of advanced glycation end products (AGEs) and high-sensitivity C-reactive protein (hs-CRP) have been examined in patients with type 2 diabetes mellitus (T2DM). However, data on patients with type 1 diabetes mellitus (T1DM) are limited. Therefore, this study was conducted to investigate the associations of major dietary patterns with serum levels of AGEs and hs-CRP among patients with T1DM. Methods A total of 229 patients with T1DM participated in this current cross-sectional study. We collected dietary data using a validated food frequency questionnaire (FFQ). The factor analysis approach was used to determine major dietary patterns. A fasting blood sample was collected from each participant to assess serum levels of AGEs and hs-CRP. The associations of dietary patterns with elevated levels of AGEs and hs-CRP were assessed using binary logistic regression. Results Patients with T1DM in the highest tertile of a Western dietary pattern had 4.32 times higher odds of having elevated AGEs than those in the lowest tertile (OR: 4.32, 95% CI: 1.86–10.05). Additionally, adherence to the Western diet was associated with 2.97 times greater odds of having elevated hs-CRP (> 3 mg/L) (OR: 2.97, 95% CI: 1.22–7.24) in these patients. Such positive associations were not observed for unhealthy and traditional dietary patterns. Moreover, higher adherence to a semi-healthy diet (characterized by high consumption of white meat, whole grains, processed meat, and a low salt intake) was associated with 87% lower odds of having elevated hs-CRP (OR: 0.13, 95% CI: 0.05–0.35). However, we found no significant association between the semi-healthy diet and AGEs levels. Conclusion We found that adherence to a Western dietary pattern was associated with elevated levels of AGEs/hs-CRP in patients with T1DM. Also, we discovered a significant inverse association between adherence to a semi-healthy diet and hs-CRP levels.

show abstract

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

Cited by 41 publications

References 89 publications

Receptor de los productos finales de glicación avanzada (RAGE) como biomarcador de la obesidad infantil

Receptor de los productos finales de glicación avanzada (RAGE) como biomarcador de la obesidad infantil

Biomarkers of intake for tropical fruits

Association of major dietary patterns with advanced glycation end products and high-sensitivity C-reactive protein in people with type 1 diabetes mellitus

Contact Info

Product

Resources

About