Dietary Sulfur-Containing Amino Acids Are Associated with Higher Prevalence of Overweight/Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study

Li, Yanchuan; Li, Yu-Zheng; Li, Rui; Li, Lan; Li, Chunlong; Huang, Min; Shi, Dan; Feng, Rennan; Sun, Changhao

doi:10.1159/000490194

Cited by 15 publications

(14 citation statements)

References 40 publications

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“…Furthermore, we found SCAAs to be positively associated with BMIz, WHtR, and fat mass, which remained significant even after controlling for several other possible confounders. Our results confirm the findings of a study done on Chinese adults, which showed an association between SCAA intake and BMI and waist circumference [68]. For both of these amino acid groups, we only estimated the dietary intake.…”

Section: Discussionsupporting

confidence: 90%

Animal Protein Intake Is Associated with General Adiposity in Adolescents: The Teen Food and Development Study

et al. 2019

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Protein plays a crucial role in the growth and development of adolescents. However, being a secondary energy source, protein’s role in obesity has been sidelined. We examined whether intake of protein (total, animal, plant), branched-chain (BCAAs), and sulfur-containing (SCAAs) amino acids are associated with general body and central obesity and body composition in a cross-sectional study among healthy adolescents. Students aged 12–18 years old (n = 601) in schools near two major Adventist universities in California and Michigan provided dietary data via a validated web-based food frequency questionnaire (FFQ) and anthropometric data during school visits. Intakes of total, animal, and plant proteins, and BCAAs and SCAAs were derived from FFQ data. We defined general body obesity with body-mass-index-for-age (BMIz) z-scores and central obesity with waist-to-height ratios (WHtR). After full adjustment for covariates, multiple regression analyses showed significant positive associations between intakes of total protein (β = 0.101, 95% CI: 0.041, 0.161), animal protein (β = 0.118, 95% CI: 0.057, 0.178), BCAAs (β = 0.056, 95% CI: 0.025, 0.087), and SCAAs (β = 0.025, 95% CI: 0.012, 0.038) with general body adiposity. Animal protein (β = 0.017, 95% CI: 0.001, 0.033) and SCAAs (β = 0.004, 95% CI: 0.000, 0.008) were also associated with central obesity. Total and animal protein and BCAA and SCAA were also significantly associated with fat mass. Our findings suggest that high protein intake may pose a possible detriment to adolescent health. Longitudinal and safety evaluation studies are recommended.

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Section: Discussionsupporting

confidence: 90%

Animal Protein Intake Is Associated with General Adiposity in Adolescents: The Teen Food and Development Study

et al. 2019

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“…In addition to taurine, the amino acids methionine and cysteine from which taurine can be produced (see Section 2.3 ) have been associated with obesity and metabolic syndrome [ 207 , 221 , 222 ], and the modulation of the bioavailability of sulphur-containing amino acids might provide further benefits, e.g., by stimulating the synthesis of the antioxidant glutathione (discussed in [ 203 ]).…”

Section: Discussionmentioning

confidence: 99%

Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes

2022

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Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of neurodegenerative disorders show reduced brain taurine concentrations. On the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. Given the possible cytoprotective actions of taurine, such cerebral accumulation of taurine might constitute a compensatory mechanism that attempts to prevent neurodegeneration. The present article provides an overview of brain taurine homeostasis and reviews the mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. We conclude that further research is needed for understanding taurine homeostasis in metabolic disorders with an impact on brain function.

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“…Third, unfortunately, data regarding dietary intake were not available to corroborate our results. However, it has recently been proved that higher dietary sulfur-containing amino acids are associated with higher prevalence of obesity, insulin resistance, and inflammation [60].…”

Section: Discussionmentioning

confidence: 99%

Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal

Lima

Ferin

Bourbon

et al. 2019

Journal of Nutrition and Metabolism

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In Azores, the standardized mortality rate for coronary artery disease (CAD) is nearly the double when compared to mainland Portugal. The aim of this study was to compare the prevalence of conventional CAD risk factors, as well as the plasma aminothiol profile (and its major determinants), between two groups of healthy subjects from Ponta Delgada (in Azores) and Lisbon (in mainland) cities, searching for precocious biomarker(s) of the disease. The study groups consisted of 101 healthy volunteers from Ponta Delgada (PDL) and 121 from Lisbon, aged 20–69 years. No differences in the prevalence of classical CAD risk factors were found between the study groups, except in physical inactivity and related central obesity, which were both higher in PDL men than in those from Lisbon. Hypercysteinemia, which seems to result from sulfur-rich amino acid diets and/or vitamin B12 malabsorption, revealed to be significantly more prevalent in PDL vs. Lisbon subjects (18% vs. 4%, P=0.001), namely, in male gender. Moreover, plasma Cys levels predicted waist circumference (β coefficient = 0.102, P=0.032) and concomitant central obesity and were also associated with insulin resistance. Nevertheless, hyperhomocysteinemia prevalence was similar in both groups, despite the fact that PDL subjects exhibited a higher rate of vitamin B12 deficiency compared to those from Lisbon (19% vs. 6%, P=0.003). Owing to the nature of this study design, a cause-effect relationship between high plasma Cys levels and central obesity or CAD risk could not be derived, but results strongly suggest that hypercysteinemia is a potential risk factor for metabolic disorders, i.e., obesity and insulin resistance, and CAD in Azores, a hypothesis that asks for confirmation through further large prospective studies.

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Dietary Sulfur-Containing Amino Acids Are Associated with Higher Prevalence of Overweight/Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study

Cited by 15 publications

References 40 publications

Animal Protein Intake Is Associated with General Adiposity in Adolescents: The Teen Food and Development Study

Animal Protein Intake Is Associated with General Adiposity in Adolescents: The Teen Food and Development Study

Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes

Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal

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