Dietary supplement adverse events: Report of a one-year poison center surveillance project

Haller, Christine; Kearney, Tom; Bent, Stephen; Ko, Richard; Benowitz, Neal L.; Olson, Kent R.

doi:10.1007/bf03160960

Cited by 66 publications

(36 citation statements)

References 15 publications

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“…Most cases in this study showed mild symptoms and a benign clinical course, which is consistent with other studies from poisons centres evaluating adverse effects related to herbal remedies and dietary supplements (Haller, 2008;Yang, 2002), where most adverse effects were mild and severe outcomes were rare.…”

Section: Discussionsupporting

confidence: 91%

“…An analysis of calls involving the ingestion of a single medication reported to a poisons centre revealed that 3.4% were related to adverse drug reactions and of these only 4.7% were caused by the group of dietary supplements/herbals/homeopathics (Vassilev, 2009). In a prospective poisons centre study, only 0.4% of the calls concerned dietary supplements, of which 33% were due to adverse effects (Haller, 2008). Since the consumption of dietary supplements is wide-spread, it is plausible that adverse effects occur regularly, as has been recently shown by Geller et al (Geller, 2015), but are probably detected only to a small extent by poisons centres or physicians.…”

Section: Discussionmentioning

confidence: 95%

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Adverse Effects of Plant Food Supplements and Plants Consumed as Food: Results from the Poisons Centres-Based PlantLIBRA Study

et al. 2016

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Plant food supplements (PFS) are products of increasing popularity and wide-spread distribution. Nevertheless, information about their risks is limited. To fill this gap, a poisons centres-based study was performed as part of the EU project PlantLIBRA. Multicentre retrospective review of data from selected European and Brazilian poisons centres, involving human cases of adverse effects due to plants consumed as food or as ingredients of food supplements recorded between 2006 and 2010. Ten poisons centres provided a total of 75 cases. In 57 cases (76%) a PFS was involved; in 18 (24%) a plant was ingested as food. The 10 most frequently reported plants were Valeriana officinalis, Camellia sinensis, Paullinia cupana, Melissa officinalis, Passiflora incarnata, Mentha piperita, Glycyrrhiza glabra, Ilex paraguariensis, Panax ginseng, and Citrus aurantium. The most frequently observed clinical effects were neurotoxicity and gastro-intestinal symptoms. Most cases showed a benign clinical course; however, five cases were severe. PFS-related adverse effects seem to be relatively infrequent issues for poisons centres. Most cases showed mild symptoms. Nevertheless, the occurrence of some severe adverse effects and the increasing popularity of PFS require continuous active surveillance, and further research is warranted. Most cases showed a benign clinical course; however, five cases were severe. Conclusions:PFS-related adverse effects seem to be relatively infrequent issues for poisons centres. Most cases showed mild symptoms. Nevertheless, the occurrence of some severe adverse effects and the increasing popularity of PFS require continuous active surveillance, and further research is warranted.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Adverse Effects of Plant Food Supplements and Plants Consumed as Food: Results from the Poisons Centres-Based PlantLIBRA Study

et al. 2016

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“…In the United States, combining caffeine and ephedrine for weight loss is not practical because of the FDA ban on ephedra alkaloids and the adverse negative side effects (Dhar et al, 2005;Haller, Meier, & Olson, 2005;Soni et al, 2004).…”

Section: Ephedra + Caffeinementioning

confidence: 99%

Dietary Supplements for Improving Body Composition and Reducing Body Weight: Where Is the Evidence?

Manore¹

2012

International Journal of Sport Nutrition and Exercise Metabolism

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Weight-loss supplements typically fall into 1 of 4 categories depending on their hypothesized mechanism of action: products that block the absorption of fat or carbohydrate, stimulants that increase thermogenesis, products that change metabolism and improve body composition, and products that suppress appetite or give a sense of fullness. Each category is reviewed, and an overview of the current science related to their effectiveness is presented. While some weight-loss supplements produce modest effects (<2 kg weight loss), many have either no or few randomized clinical trials examining their effectiveness. A number of factors confound research results associated with the efficacy of weight-loss supplements, such as small sample sizes, short intervention periods, little or no follow-up, and whether the supplement is given in combination with an energy-restricted diet or increased exercise expenditure. There is no strong research evidence indicating that a specific supplement will produce significant weight loss (>2 kg), especially in the long term. Some foods or supplements such as green tea, fiber, and calcium supplements or dairy products may complement a healthy lifestyle to produce small weight losses or prevent weight gain over time. Weight-loss supplements containing metabolic stimulants (e.g., caffeine, ephedra, synephrine) are most likely to produce adverse side effects and should be avoided.

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“…), bilberry (Vaccinium myrtillus), and cat's claw (Uncaria tomentosa). 23,24 The most frequent calls, in descending order of frequency, involved St. John's wort, ma huang, echinacea, guarana, ginkgo, ginseng, valerian, tea tree oil, goldenseal, arnica, yohimbe, and kava kava. According to the Botanical Safety Handbook, 20 coneflower, saw palmetto, aloe (gel used internally), and cayenne (used internally) should be considered safe when used appropriately.…”

Section: Active Herbal Constituentsmentioning

confidence: 99%

Hazards Associated with the Use of Herbal and Other Natural Products

Hausner

Poppenga

2013

Small Animal Toxicology

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Dietary supplement adverse events: Report of a one-year poison center surveillance project

Cited by 66 publications

References 15 publications

Adverse Effects of Plant Food Supplements and Plants Consumed as Food: Results from the Poisons Centres-Based PlantLIBRA Study

Adverse Effects of Plant Food Supplements and Plants Consumed as Food: Results from the Poisons Centres-Based PlantLIBRA Study

Dietary Supplements for Improving Body Composition and Reducing Body Weight: Where Is the Evidence?

Hazards Associated with the Use of Herbal and Other Natural Products

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