Dietary supplementation of grape seed tannin extract stimulated testis development, changed fatty acid profiles and increased testis antioxidant capacity in pre-puberty hu lambs

Cryopreservation and storage of semen for artificial insemination (AI) result in excessive accumulation of reactive oxygen species (ROS). This leads to a shortened life span and reduced motility of spermatozoa post-thawing, with consequent impairment of their function. However, certain levels of ROS are essential to facilitate the capacitation of spermatozoa required for successful fertilisation. Tannins, as well-known antioxidant compounds, may act as ROS binders/acceptors/scavengers to inhibit the damaging effects of ROS. This review comprises an analysis of the semen cryopreservation protocol and health functions of tannins, as well as the effects of ROS on fresh and cryopreserved semen’s longevity and fertilisation. Additionally, we surveyed available evidence of the effects of tannin extract feed supplementation on male fertility. We furthermore interrogated existing theories on tannin use as a potential additive to semen extenders, its relationship with semen quality, and to what degree existing theories have been investigated to develop testable new hypotheses. Emphasis was placed on the effects of tannins on ROS, their involvement in regulating sperm structure and function during cryopreservation, and on post-thaw sperm motility, capacitation, and fertilising ability. The diverse effects of tannins on the reproductive system as a result of their potential metal ion chelation, protein precipitation, and biological antioxidant abilities have been identified. The current data are the first to support the further investigation of the incorporation of tannin-rich plant extracts into semen extenders to enhance the post-thaw survival, motility, and fertilising ability of cryopreserved spermatozoa.

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“…Vitis vinifera (Grape) seed tannin extract (GPE) [69] GPE has a 95% purity coefficient (56.5% condensed tannins)…”

Section: Spondias Mombin Leafmentioning

confidence: 99%

Potential Use of Tannin Extracts as Additives in Semen Destined for Cryopreservation: A Review

Liman

Hassen

McGaw

et al. 2022

Animals

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“…As mentioned earlier, weaning can trigger oxidative stress and inflammatory responses and down-regulate the immunity of calves. Previous experiments in cows, calves and lambs reported that the supplementation of grape seed products could reduce inflammatory reactions and improve oxidation resistance, and thus is conducive to promoting production performance [10,13,14]. Although Gse can improve the production performance and antioxidant ability of animals, research on the role of Gse as an effective feed additive in young ruminants is limited.…”

Section: Introductionmentioning

confidence: 99%

Grape Seed Extract as a Feed Additive Improves the Growth Performance, Ruminal Fermentation and Immunity of Weaned Beef Calves

Zhang

Zhou

et al. 2023

Animals

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The purpose of this research was to evaluate effects of grape seed extract (Gse) supplementation on the growth performance; ruminal fermentation; nutrient digestibility; and serum biochemical, antioxidative, and immune parameters of weaned beef calves. A total of 30 Simmental crossbred male calves with similar age and body weight were randomly allocated to two groups: a control group with no Gse (CON) and a Gse supplementation group (GSE) (4 g/d Gse per animal). The results show that, compared with the CON group, the average daily gain significantly increased (p = 0.043) in the GSE group. The ruminal contents of microbial protein and butyrate in GSE group were higher (p < 0.05) than those in the CON group. Additionally, calves fed Gse displayed increased (p < 0.05) dry matter and neutral detergent fiber digestibility. Moreover, the serum concentrations of triglyceride, catalase, superoxide dismutase, immunoglobulin G and immunoglobulin M were higher (p < 0.05) in the GSE group than those in the CON group. However, opposite tendencies of non-esterified fatty acid, malondialdehyde, tumor necrosis factor-α and interleukin-6 were found between the two groups. Overall, the supplementation of Gse can improve ruminal fermentation, nutrient digestibility, antioxidant ability, and immunity, as well as promoting the healthy growth of weaned cross-breed beef calves.

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“…Winery waste represents an essential source of soluble and insoluble fibers and complex and straightforward polyhydroxy phenols, proteins, and oils [16][17][18][19][20]. These products are successfully used in foods, cosmetics, drugs, or animal feed components to improve the products' physicochemical properties [21][22][23][24][25][26][27][28]. The antioxidant and antimicrobial activity presented by the grape pomace is related to its polyhydroxy phenol composition [29].…”

Section: Introductionmentioning

confidence: 99%

White Grape Pomace Valorization for Remediating Purposes

et al. 2022

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The present investigation focuses on a possible alternative to reduce grape pomace’s negative impact on the environment by exploiting its capacities for wastewater remediation. Therefore, three directions are followed: (1) the characterization of white grape byproducts’ antioxidant and antiradical properties; (2) the determination of organophosphorus compound concentration that might be present in the samples; and (3) the evaluation of the possible use for wastewater remediation. The grape pomace was used for obtaining different extracts considering different extraction conditions. The hydroalcoholic extracts have an increased amount of total phenolic content. The lyophilized hydroalcoholic extract showed high total phenolic content (159.52 mg/100 g) and low organophosphorus content (0.257 ± 0.015 nmol). The lowest DPPH antiradical-scavenging activities were obtained for the extracts in ethanol obtained from refrigerated pomace (0.055) and for dried pomace (0.045).

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Dietary supplementation of grape seed tannin extract stimulated testis development, changed fatty acid profiles and increased testis antioxidant capacity in pre-puberty hu lambs

Cited by 13 publications

References 43 publications

Potential Use of Tannin Extracts as Additives in Semen Destined for Cryopreservation: A Review

Potential Use of Tannin Extracts as Additives in Semen Destined for Cryopreservation: A Review

Grape Seed Extract as a Feed Additive Improves the Growth Performance, Ruminal Fermentation and Immunity of Weaned Beef Calves

White Grape Pomace Valorization for Remediating Purposes

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