Dietary supplementation of n-3 polyunsaturated fatty acid alters endometrial expression of genes involved in prostaglandin biosynthetic pathway in breeding sows ( Sus scrofa )

Gokuldas, P.P.; Singh, Sanjay K.; Tamuli, M.K.; Naskar, S.; Vashi, Yoya; Thomas, R.; Barman, Keshab; Pegu, Seema Rani; Chethan, Sharma G.; Agarwal, Sudhir K.

doi:10.1016/j.theriogenology.2018.01.009

Cited by 12 publications

(4 citation statements)

References 40 publications

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“…it is possible that truly relevant effects could be more evident at older ages. A recent study with breeding sows reported that omega-3 PUFA modulates the endometrial expression of genes with relevant roles in pathways of prostaglandin synthesis during early gestation, probably influencing subsequent reproductive events (Gokuldas et al, 2018). Thus, although supplementation with omega-3 PUFA may be helpful to improve female reproductive performance, long-term effects on ovarian function still need to be investigated in future studies, preferably evaluating gilts until puberty.…”

Section: Discussionmentioning

confidence: 99%

Effects of supplying omega-3 polyunsaturated fatty acids to gilts after weaning on metabolism and ovarian gene expression1

Otte

Moreira

Bianchi

et al. 2018

Journal of Animal Science

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Omega-3 PUFA may benefit sow reproductive performance, but effects on weaned gilts are unknown. This study evaluated the effects of supplementing omega-3 PUFA to gilts after weaning on growth, metabolic markers, and gene expression of steroidogenic enzymes and hormone receptors. For 52 d, gilts in the control group were fed 100 g/d of regular diets, whereas gilts in the omega-3 group were fed 75 g/d of such diets plus 25 g/d of the microalgae Schizochytium sp. (3.5 g/d of omega-3 PUFA; n = 8 gilts/group). Blood samples were collected at day 0, day 21, and day 52. Total serum cholesterol levels were lower for the omega-3 group than for the control group (P < 0.05), but high-density lipoprotein-cholesterol levels were reduced at day 52 for both groups (P < 0.05). Gilts in the omega-3 group presented lower feed intake, better feed conversion, and less-intense immunolabeling for leptin and its receptor in the cytoplasm of oocytes included in primordial/primary follicles than gilts in the control group (P < 0.05). The expression of genes coding for cholesterol side-chain cleavage and aromatase enzymes and the LH receptor in follicular cells was lower for supplemented gilts (P < 0.05). Compared with controls, supplemented gilts presented decreased serum cholesterol levels and better feed conversion, but leptin presence and gene expression for steroidogenic enzymes and for the LH receptor were lower at ovarian level.

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Section: Discussionmentioning

confidence: 99%

Effects of supplying omega-3 polyunsaturated fatty acids to gilts after weaning on metabolism and ovarian gene expression1

Otte

Moreira

Bianchi

et al. 2018

Journal of Animal Science

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Section: Mechanism Of Functional Fatty Acids In Increasing the Livest...mentioning

confidence: 99%

“…Furthermore, the proportion of functional fatty acids, especially PUFAs, in diet alters the phospholipid composition in the cell membrane, indicating the importance of fatty acids, because different PG precursors compete for the same enzyme system [121]. Previous research has demonstrated that adding functional fatty acids to feed can regulate the gene expression of important enzymes in the PG biosynthesis pathway, such as PTGS [122], in the first trimester of pregnancy, thereby benefiting the overall porcine reproductive process [123]. In addition to the above 2 major lipid metabolic pathways that alter endometrial receptivity in livestock, lysophospholipids [124], endogenous cannabinoids [125] and sphingolipids [10] are also regulated by lipid metabolism and play crucial roles in endometrial receptivity.…”

Section: Functional Fatty Acids Improve Endometrial Receptivity By Af...mentioning

confidence: 99%

Role of functional fatty acids in modulation of reproductive potential in livestock

Zeng

Liu

et al. 2023

J Animal Sci Biotechnol

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Fatty acids are not only widely known as energy sources, but also play important roles in many metabolic pathways. The significance of fatty acids in modulating the reproductive potential of livestock has received greater recognition in recent years. Functional fatty acids and their metabolites improve follicular development, oocyte maturation and embryo development, as well as endometrial receptivity and placental vascular development, through enhancing energy supply and precursors for the synthesis of their productive hormones, such as steroid hormones and prostaglandins. However, many studies are focused on the impacts of individual functional fatty acids in the reproductive cycle, lacking studies involved in deeper mechanisms and optimal fatty acid requirements for specific physiological stages. Therefore, an overall consideration of the combination and synergy of functional fatty acids and the establishment of optimal fatty acid requirement for specific stages is needed to improve reproductive potential in livestock.

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“…A previous study [ 49 ] demonstrated that the addition of n-3 PUFAs in the diet can regulate the gene expression of key enzymes, such as cyclooxygenase (COX) [ 50 ], in the PG biosynthesis pathway during early pregnancy, thereby exerting a beneficial effect on the overall reproductive response of sus scrofa. Supplementation with n-3 PUFAs and methionine can improve performance in the second trimester of pregnancy [ 51 ].…”

Section: Pufas Pgs Cox-2 Cox-1 and Endometrial Receptivitymentioning

confidence: 99%

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

et al. 2021

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Endometrial receptivity plays a crucial role in fertilization as well as pregnancy outcome in patients faced with fertility challenges. The optimization of endometrial receptivity may help with normal implantation of the embryo, and endometrial receptivity may be affected by numerous factors. Recently, the role of lipids in pregnancy has been increasingly recognized. Fatty acids and their metabolites may be involved in all stages of pregnancy and play a role in supporting cell proliferation and development, participating in cell signaling and regulating cell function. Polyunsaturated fatty acids, in particular, are essential fatty acids for the human body that can affect the receptivity of the endometrium through in a variety of methods, such as producing prostaglandins, estrogen and progesterone, among others. Additionally, polyunsaturated fatty acids are also involved in immunity and the regulation of endometrial decidualization. Fatty acids are essential for fetal placental growth and development. The interrelationship of polyunsaturated fatty acids with these substances and how they may affect endometrial receptivity will be reviewed in this article.

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Dietary supplementation of n-3 polyunsaturated fatty acid alters endometrial expression of genes involved in prostaglandin biosynthetic pathway in breeding sows ( Sus scrofa )

Cited by 12 publications

References 40 publications

Effects of supplying omega-3 polyunsaturated fatty acids to gilts after weaning on metabolism and ovarian gene expression1

Effects of supplying omega-3 polyunsaturated fatty acids to gilts after weaning on metabolism and ovarian gene expression1

Role of functional fatty acids in modulation of reproductive potential in livestock

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

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