Dietary supplementation of sodium butyrate may benefit growth performance and intestinal function in juvenile grass carp (<i>Ctenopharyngodon idellus</i>
)

Liu, Mengmei; Guo, Wei; Wu, Fan; Qu, Qicai; Tan, Qingsong; Gong, Wangbao

doi:10.1111/are.13230

Cited by 76 publications

(75 citation statements)

References 34 publications

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“…The supplementation of tributyrin at 0.1% and 0.2% levels in SBM-based diets significantly improved fish growth performance, resulting in comparable values to that of fish fed the FM diet (Table 3), which is consistent with findings in poultry (Antongiovanni, Buccioni, Minieri, Galigani, & Rapaccini, 2010;Antongiovanni et al, 2007) and pigs (Dong et al, 2016;Hou, Liu, Hu, & Shen, 2006). However, a significant decrease in growth the major energy source of colonocyte epical cells (Hamer et al, 2010;Wong, De, Kendall, Emam, & Jenkins, 2006), butyric acid and butyrate have been administrated to promote the proliferation and differentiation of intestine villi epical cells, which subsequently increase intestine surface area, promoting the digestion and utilization of nutrients in mammalian and aquatic animal studies (Biagi et al, 2007;Claus, Günthner, & Letzquss, 2007;Gao, Trond, Karld, Michael, & Margareth, 2011;Liu et al, 2017Liu et al, , 2019Lu et al, 2008).…”

Section: Discussionsupporting

confidence: 84%

“…The present study indicated that the tributyrin supplementation restricted TJ expression as reported in mammalian studies . Therefore, the significant decrease in MLCK expression in fish fed TB0.1 diet may account for the improvement of physical barrier, and similar results were reported in other aquaculture animals, such as grass carp (Liu et al, 2017). Besides, butyric acid also exerted anti-inflammatory effects through inhibiting the activation of NF-κB signalling and subsequently the initiation of pro-inflammatory genes .…”

Section: Discussionsupporting

confidence: 74%

“…The supplementation of tributyrin at 0.1% level significantly increased mucosal fold height, perimeter ratio, and microvilli length and density (Figure and Table ; p < .05). As the major energy source of colonocyte epical cells (Hamer et al, ; Wong, De, Kendall, Emam, & Jenkins, ), butyric acid and butyrate have been administrated to promote the proliferation and differentiation of intestine villi epical cells, which subsequently increase intestine surface area, promoting the digestion and utilization of nutrients in mammalian and aquatic animal studies (Biagi et al, ; Claus, Günthner, & Letzquss, ; Gao, Trond, Karld, Michael, & Margareth, ; Liu et al, , ; Lu et al, ). Tributyrin was slowly hydrolysed into butyric acids in the entire intestine by pancreatic lipase (Conley et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of investigation results indicated positive effects of SB in improving growth performance of fish species such as grass carp (Ctenopharyngodon idellus; Liu et al, 2017), turbot (S. maximus L. ;Liu et al, 2019) and gilthead sea bream (Sparus aurata; Robles et al, 2013), while Owen et.al pointed out the invalidity of dietary SB supplementation in African catfish (Owen, Waines, Bradley, & Davies, 2006). Similar results were also reported in stock animal studies (Biagi, Piva, Moschini, Vezzali, & Roth, 2007;Weber & Kerr, 2008), which may attribute to the fast absorption of SB in the stomach, resulting in a limited amount of SB reaching the distal intestine (Mallo, Balfagón, Gracia, Honrubia, & Puyalto, 2012).…”

mentioning

confidence: 99%

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Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tan

Zhu

et al. 2020

Aquac Res

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Six equal‐protein and equal‐lipid diets were formulated: the fish meal (FM) diet, the soya bean meal (SBM) diet with 40% of FM protein replaced by SBM protein and tributyrin (TB) diets with 0.05% (TB0.05), 0.10% (TB0.1), 0.20% (TB0.2) and 0.40% (TB0.4) tributyrin supplemented in the SBM‐based diet. Each kind of diet was randomly fed to triplicate tanks with 20 fish per tank. Fish were fed apparent satiation twice daily for 56 days. No significant difference in weight gain rate (WGR) and feed efficiency rate (FER) was observed between fish fed the FM, TB0.1 and TB0.2 diets (p > .05). Muscle histidine and arginine proportion of fish fed TB0.1 diet was significantly higher than that of fish fed the SBM diet (p < .05). Intestine morphology results indicated that the supplementation of 0.1% tributyrin significantly improved the mucosal fold height, microvilli length and microvilli density when compared with those of fish fed the SBM diet (p < .05). The supplementation of dietary tributyrin suppressed the pro‐inflammatory gene expression, which may be due to the improvement of physical barrier and modification of microbial communities, such as Acinetobacter, Rhodocyclaceae, Brevundimonas, Sphingopyxis, Hydrogenophaga, Methyloversatilis and Devosia. In conclusion, dietary 0.1% tributyrin supplementation in high‐soya bean meal diet improved growth performance, flesh quality and intestinal morphology structure integrity of yellow drum.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tan

Zhu

et al. 2020

Aquac Res

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“…However, only a few studies focus on the mechanism of SB in protecting intestinal health in fish species (Liu et al, ). Liu suggested that the proper dietary supplementation level of chemical stabilization dosage form sodium butyrate for the juvenile grass carp is 2000 mg/kg (Liu et al, ), but yellow drum as marine carnivorous fish have a shorter intestinal tract than grass carp. This study was intended to investigate whether SB could improve the intestinal physical barrier function and decrease the pro‐inflammatory response, or not, and to determine the possible underlying mechanism when yellow drum were fed an SBM‐based diet.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary sodium butyrate on growth, diet conversion, body chemical compositions and distal intestinal health in yellow drum ( Nibea albiflora , Richardson)

Wang

Xie

et al. 2019

Aquac Res

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The present study was conducted to investigate the effects of sodium butyrate (SB) on the physical barrier function, pro‐inflammatory response and possible underlying mechanisms in the distal intestine (DI) of yellow drum when fed a high‐SBM diet. Three iso‐proteic and iso‐lipidic diets were formulated with fish meal (FM, the control), 45% fish meal protein replaced by SBM (SBM) and 45% fish meal protein replaced by SBM but supplemented with 0.15% SB (SBM + SB). Fish were fed twice daily for 10 weeks. Results indicated that SB supplementation significantly increased the specific growth rate (SGR) and feed efficiency ratio (FER) and methionine content of muscle when compared with those of fish fed the SBM diet (p < .05). The morphologic histology results showed that SB dramatically improved the physical barrier structure, characterized as increases of fold height (FH) and muscular thickness (MT) (p < .05). RT‐qPCR data were accordant with morphologic histology results, in which claudin 3, claudin 4 and occludin were increased while claudin 7 and myosin light chain kinase (MLCK) mRNA expression levels were decreased (p < .05). Sodium butyrate also exerted anti‐inflammatory function, which may be attributed to the suppression of nucleus p65 protein expression. Results suggest SB can be incorporated in high‐SBM diets to ameliorate the negative consequences of alternative dietary ingredients on yellow drum physiology.

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A comparison of digestive strategies for fishes with different feeding habits: Digestive enzyme activities, intestinal morphology, and gut microbiota

Jiao,

Zhang,

Limbu

et al. 2023

Ecology and Evolution

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Fish feeding habit determines the digestive tract structure and intestinal microflora. However, the relationship between feeding habit, digestive intestinal morphology, and microbial diversity of omnivorous, herbivorous, plankton feeder, and carnivorous fish from the same environment has not been compared. This study compared the digestive enzyme activities, intestinal morphology, and intestinal microflora of omnivorous (Carassius auratus), herbivorous (Ctenopharyngodon idellus), carnivorous (Siniperca chuatsi), and plankton feeder (Schizothorax grahami) fishes and predicted the potential functions of specific microflora on different nutrients. Twelve intestine samples were collected from each of the four fishes from Dianchi Lake. The composition and diversity of microbial communities were determined by using high‐throughput sequencing of 16S rDNA. The results showed that the carnivorous fish (S. chuatsi) had higher trypsin and pancrelipase activities in the hepatopancreas and enteropeptidase in the intestine, but lower amylase activities in the intestine. The carnivorous fish intestine had more microvilli branches and complex structures than other fish species in the order carnivorous > herbivorous > plankton feeder > omnivorous. The intestinal microflora diversity was higher in the omnivorous fish and followed the order omnivorous > herbivorous > plankton feeder > carnivorous. Acinetobacter species and Bacteroides species were the most dominant flora in the carnivorous and herbivorous fishes, respectively. Acinetobacter species and Pseudomonas species might help the host to digest protein, while Bacteroidetes species may help the host to digest cellulose. Taken together, feeding habit determines the digestive enzyme activities, intestinal tissue morphology, and differential colonization of fish intestinal flora. The knowledge obtained is useful in feed formulation and feeding practices for the studied fish species.

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Dietary supplementation of sodium butyrate may benefit growth performance and intestinal function in juvenile grass carp (Ctenopharyngodon idellus )

Cited by 76 publications

References 34 publications

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Effects of dietary sodium butyrate on growth, diet conversion, body chemical compositions and distal intestinal health in yellow drum ( Nibea albiflora , Richardson)

A comparison of digestive strategies for fishes with different feeding habits: Digestive enzyme activities, intestinal morphology, and gut microbiota

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