Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients

Paschos, George K.; Magkos, Faidon; Panagiotakos, D.; Votteas, V.; Zampelas, Antonis

doi:10.1038/sj.ejcn.1602631

Cited by 108 publications

(82 citation statements)

References 31 publications

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“…SDG reduced the angiotensin I-induced rise in the arterial pressures and hence SDG was a potent Angiotensin-Converting Enzyme (ACE) inhibitor (Paschos et al, 2007;Prasad, 2009). And SDG supplementation could protect against the development of chronic diseases, cancer and diabetes on animal studies using various models of rat, mice and rabbit (Adolphe et al, 2010).…”

Section: The Statistical Analysismentioning

confidence: 99%

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Jeong¹,

Kim²,

Chon³

et al. 2017

J. Milk Sci. Biotechnol.

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Flaxseed (Linum usitatissimum L.) is an important food, oil, and fiber crop of the family Linaceae. Although flaxseed has been consumed as a food ingredient for several centuries, its nutritional benefits have not yet been completely established. Flaxseed is a good source of lignans, nonstarch polysaccharides, and high-quality proteins. Hence, in this study, we aimed to prepare a bioactive kefir containing flaxseed and to examine the physicochemical characteristics of kefir containing different concentrations of flaxseed. We investigated the pH, and sensory evaluation of bioactive Kefir containing different concentrations of flaxseed. We investigated the pH, total anthocyanins (TAs), and sensory evaluation of bioactive Kefir containing different concentrations of flaxseed. The pH of this bioactive kefir decreased, whereas the TA content increased with increasing incubation time; however, these parameters were not affected by the amount of added flaxseed. As the addition rate of flaxseed increased, the scores for overall acceptability, texture, color, flavor, and taste in sensory evaluations were generally the same as or lower than the control. There were no significant differences in overall acceptability, texture, color, flavor, and taste between the control and treated groups. Therefore, further studies are needed to develop methods for production of health-improving kefir as a dietary supplement based on the functional properties of flaxseed.

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Section: The Statistical Analysismentioning

confidence: 99%

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Jeong¹,

Kim²,

Chon³

et al. 2017

J. Milk Sci. Biotechnol.

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“…Many studies have shown its positive effects when used as a supplemental feeding. These effects are manifested as improvement in lipid profile 12 , reducing the development of type 1 and type 2 diabetes mellitus 13 , reducing blood pressure 14 , and controlling weight gain 15 .…”

Section: Introductionmentioning

confidence: 99%

Impact of flaxseed intake upon metabolic syndrome indicators in female Wistar rats

Brant

Cardozo²,

Velarde³

et al. 2012

Acta Cir. Bras.

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PURPOSE:To evaluate whether the prolonged consumption of flaxseed minimize the factors that trigger MS in healthy rats. METHODS:Pregnant rats were divided immediately after delivery into two groups during the lactation period, a control group (CG) receiving casein-based diet with 17% of protein, and a Flaxseed group (FG) with casein-based diet plus 25% of flaxseed. At weaning, 12 offspring of each group continued to receive the same feed but with 10% of protein up to 200 days old. RESULTS:FG showed a significant reduction in body weight (p=0.001), total cholesterol levels (p<0.0001), triglycerides (p=0.0001), and glucose (p=0.001). CONCLUSION:The flaxseed alters the indicators related to development of metabolic syndrome, because it has beneficial effects on lipids and glucose profiles and prevents the excess of body weight gain. MÉTODOS: Ratos fêmeas grávidas foram distribuidas após o parto em dois grupos durante o período de lactação: grupo controle (GC)recebendo dieta à base de caseína com 17% de proteína, e um grupo Linhaça (GL), com dieta à base de caseína adicionada de 25% de semente de linhaça. Ao desmame, 12 filhotes de cada grupo continuaram a receber as rações citadas acima, porém com 10% de proteína, até os 200 dias de vida. RESULTADOS:O GL mostrou uma redução significativa do peso corporal (p=0,001), no colesterol total (p<0,0001), triglicerídeos (p=0,0001) e na glicemia (p=0,001). CONCLUSÃO:A linhaça altera os indicadores relacionados ao desenvolvimento da síndrome metabólica por ter efeitos benéficos no perfil lipídico e glicêmico, e previne o excesso de ganho de peso corporal.Descritores: Linho. Triglicerídeos. Metabolismo. Glucose. Ratos.Brant LHC et al.

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“…ALA as an antihypertensive agent has been studied in a limited number of studies,63 and the lack of effect on blood pressure with ALA is at odds with previous clinical studies that demonstrate the hypotensive effects of ALA in hypertensive individuals 56. Mice, however, are deficient in the enzyme that is responsible for the endogenous metabolism of ALA64 and thus may respond differently to ALA than humans.…”

Section: Discussionmentioning

confidence: 99%

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Alfaidi

Chamberlain

Rothman

et al. 2018

JAHA

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BackgroundHypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established role in atherosclerosis and inflammation, although whether IL‐1 inhibition modulates blood pressure is unclear.Methods and ResultsMale apoE−/− (apolipoprotein E–null) mice were fed either a high fat diet or a high fat diet plus DHA (300 mg/kg per day) for 12 weeks. Blood pressure and cardiac function were assessed, and effects of DHA on wall shear stress and atherosclerosis were determined. DHA supplementation improved left ventricular function, reduced wall shear stress and oscillatory shear at ostia in the descending aorta, and significantly lowered blood pressure compared with controls (119.5±7 versus 159.7±3 mm Hg, P<0.001, n=4 per group). Analysis of atheroma following DHA feeding in mice demonstrated a 4‐fold reduction in lesion burden in distal aortas and in brachiocephalic arteries (P<0.001, n=12 per group). In addition, DHA treatment selectively decreased plaque endothelial IL‐1β (P<0.01).ConclusionsOur findings revealed that raised blood pressure can be reduced by inhibiting IL‐1 indirectly by administration of DHA in the diet through a mechanism that involves a reduction in wall shear stress and local expression of the proinflammatory cytokine IL‐1β.

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Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients

Cited by 108 publications

References 31 publications

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Impact of flaxseed intake upon metabolic syndrome indicators in female Wistar rats

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

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