Impact of flaxseed intake upon metabolic syndrome indicators in female Wistar rats

Abstract

PURPOSE:To evaluate whether the prolonged consumption of flaxseed minimize the factors that trigger MS in healthy rats. METHODS:Pregnant rats were divided immediately after delivery into two groups during the lactation period, a control group (CG) receiving casein-based diet with 17% of protein, and a Flaxseed group (FG) with casein-based diet plus 25% of flaxseed. At weaning, 12 offspring of each group continued to receive the same feed but with 10% of protein up to 200 days old. RESULTS:FG showed a significant reduction in body weight (p=0.001), total cholesterol levels (p<0.0001), triglycerides (p=0.0001), and glucose (p=0.001). CONCLUSION:The flaxseed alters the indicators related to development of metabolic syndrome, because it has beneficial effects on lipids and glucose profiles and prevents the excess of body weight gain. MÉTODOS: Ratos fêmeas grávidas foram distribuidas após o parto em dois grupos durante o período de lactação: grupo controle (GC)recebendo dieta à base de caseína com 17% de proteína, e um grupo Linhaça (GL), com dieta à base de caseína adicionada de 25% de semente de linhaça. Ao desmame, 12 filhotes de cada grupo continuaram a receber as rações citadas acima, porém com 10% de proteína, até os 200 dias de vida. RESULTADOS:O GL mostrou uma redução significativa do peso corporal (p=0,001), no colesterol total (p<0,0001), triglicerídeos (p=0,0001) e na glicemia (p=0,001). CONCLUSÃO:A linhaça altera os indicadores relacionados ao desenvolvimento da síndrome metabólica por ter efeitos benéficos no perfil lipídico e glicêmico, e previne o excesso de ganho de peso corporal.Descritores: Linho. Triglicerídeos. Metabolismo. Glucose. Ratos.Brant LHC et al.

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

“…Weekly weight measurements showed that diet supplementation with flaxseed didn't block rabbits' growth and in contrast, we recorded a very trivial improvement of the LSI group weight with less heavy carcasses than the CTRL one, but not in a significant way (Tables 1). These results are in concordance with those reported by Brant et al (2012), who found flaxseed to prevent excess of body weight gain in pregnant rats because of its beneficial effects on lipids and glucose profiles. This same observation had also been made by Daleprane et al (2010) in weaned rats, for the reason that flaxseed fibres and long-chain N-3 polyunsaturated fatty acid content could reduce both appetite sensation and energy intake (Kristensen et al, 2013).…”

Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams

“…Due to its composition, studies have related the ingestion of flaxseed with a reduction in cardiovascular risks such as lipid profile improvement, blood pressure reduction and decreased formation of atheroma plaque …”

The effects of a diet formulation with oats, soybeans, and flax on lipid profiles and uricemia in patients with AIDS and dyslipidemia

“…Triturated fl ax was used because it allows for the absorption of alpha-linolenic acid 22 , a major contributor to the hypolipidemic effect 14,23 ; furthermore, the antioxidants present in flaxseed act synergistically to enhance the prevention of infl ammatory disorders and heart disease 24 . Molena-Fernandes 25 showed that the consumption of 10g fl axseed and/or 20g per capita of linseed resulted in the rapid elimination of cholesterol, and Couto 26 found a signifi cant reduction in the basal and fi nal serum triglyceride levels (81.8%) of 2 groups of monitored patients who consumed 10g and 20g per capita of triturated fl axseed.…”

“…Flaxseed is one of the richest sources of alpha-linolenic acid and lignans, both of which can reduce total cholesterol and LDLcholesterol [12][13][14][15] . In addition to their cholesterol-lowering effect, fl axseed 16,18 and oat 19 have been reported to cause a regression of the atherosclerosis process in animals.…”